Inflammatory myofibroblastic tumor of the lumbar spinal canal

Abstract

Rationale:Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor. IMT can arise in multiple anatomic locations. IMT of the lumbar spinal canal is exceptionally rare.Patient concerns:Here, we report the case of a 56-year-old male patient with an IMT who was in good health until 1 year prior to admission, when he began experiencing pain in both lower extremities and the lower back.Interventions:A space-occupying lesion in the lumbar canal was identified by magnetic resonance imaging and then surgically resected.Diagnoses:Histopathological analysis of the lesion revealed a composition of mucous edema, inflammatory cells, collagenous fibers, and spindle cells that were diffuse and positive for smooth muscle actin and CD68; focal positive for vimentin and desmin; and negative for CD34 (marker of vascular endothelial cells), CD21, CD23, CD35, S-100, Epstein–Barr virus infection, Ki-67, and anaplastic lymphoma kinase. Thus, the diagnosis was an IMT of the lumbar canal.Outcomes:In the spinal canal, IMT should be considered in the evaluation of tumors although it is a very rare diagnosis. It is a benign lesion, but it has potential for invasion and recurrence.Lessons:There are no characteristic imaging features of these tumors, but they can be addressed by complete surgical excision. Patients with these lesions should undergo frequent long-term follow-up to detect and address recurrence.

The Clinical and Radiological Characteristics of Inflammatory Myofibroblastic Tumor Occurring at Unusual Sites

“…The imaging manifestations of IMT are variable and display no characteristic representation on CT or MR imaging, despite recent improvements in imaging technology [5]. IMT have a similar appearance to other typical spinal epidural lesions, such as meningioma, lymphoma, and metastatic tumor [6].…”

A Rare Cause of Chronic Dysphagia: Pulmonary Inflammatory Myofibroblastic Tumor with Distal Esophagus Invasion

“…Meanwhile, not only the morphology of this neoplasm was highly consistent with IMT histologically in our case, but also the neoplasm was partially positive for P16, WT-1, and smooth muscle actin (SMA), which are reported to express in IMT and their expression is considered to be an evidence of differential diagnosis among IMT, myo broblastoma and solitary brous tumor. 4,7 In Simon et al 5 case, however, these stains were negative.…”

“…A wide range has IMT been reported, it is mostly found in soft tissue of children and young adults. 4 The etiology of IMT is still controversial, the arguments of which can be divided into two parts: one regarded IMT as neoplasm rather than reactive subset, 7 especially the ALK positive IMT was reported to be associated with local recurrence, 8 however, rare has IMT been found to metastasis. 3 The other held the causes of IMT include Epstein-Barr virus, human herpes virus eight, re ux, trauma, and overexpression of interleukin 6, 9 which were identi ed as the unregulated in ammation.…”

“…IMT is rare mesenchymal tumor, [1][2][3] which happens mostly in children and young adults. 4 It is regarded as intermediate tumor because of a rare possibility of recurrence. 5 The symptoms or imaging ndings of IMT vary from its location and histological evidence can be of great help on diagnosis.…”

Inflammatory Myofibroblastic Tumor of Spinal Canal: Brief Case Report

“…It demonstrates a propensity for lung and omentum but can also occur in other anatomical sites, such as the alimentary tract, genitourinary tract, thyroid, spleen, liver, and larynx; spinal meningeal involvement is quite rare. 2,3 IMT is not a single entity but rather a term covering a vast array of nonspecific chronic inflammatory benign mass lesions characterized by proliferation of myofibroblasts. 4 The pathogenesis of IMT remains a matter of debate.…”