Inflammatory myofibroblastic tumor of the thyroid in its sclerosing subtype: the first case report

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare entity. It is usually found in the lung and upper respiratory tract. Its location in the thyroid is exceedingly rare. Only seven cases of IMT of the thyroid were reported in the literature, mostly after the age of 50 years. The predominant histological pattern in all previously reported cases is that of marked plasma cell infiltrate. We report the detailed clinico-pathological and immunophenotypical features of a case of IMT of the thyroid in an 18-year-old girl with a family history of goiter. Our case is unique because it is the first and only known case of IMT of the thyroid in its alternative sclerosing subtype.

Inflammatory Myofibroblastic Tumor of the Thyroid Gland: A Brief Case Report

“…2 In comparison with IMT in other sites, most reported thyroid cases showed a prominent plasma cell infiltrate embedded in a variable degree of fibrous stroma. Only two of the reported cases exhibited morphologic features of IMT and one of those cases was reported as IMT of the thyroid gland 3,4. Extrapulmonary IMT affects children and young adults within the first two decades of life, and is rare after 30 years 1.…”

“…Moreover, most cases in the thyroid have been described as cases of PCG,2 and the myofibroblastic component in the thyroid cases is usually not prominent. Only one case has reported IMT of the thyroid gland 3. This study reports and discusses the differential diagnosis of an IMT of the thyroid gland that occurred in a 50-year-old Korean woman and which showed a predominantly myofibroblastic proliferation.…”

Inflammatory Myofibroblastic Tumor of the Breast

“…IMTs have been observed predominantly in young patients and have been encountered virtually in any anatomical location such as the lungs [2], mesentery [4], omentum [3], retroperitoneum [5], extremities [6], head [7], liver [10], spleen [11], thyroid [12], and urinary bladder [13]. Notably, reported cases on IMTs/IPTs of the breast are very scarce [1, 9, 14–34].…”

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

“…Most IMTs occur in the lungs and airways of young patients. However, other organs, including mesentery, omentum, stomach, small intestine, large intestine, mediastinum, retroperitoneum, liver and bladder, have been documented (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Among these extrapulmonary IMTs, 43% arise in the mesentery and omentum (29).…”

“…IMT used to be considered as an inflammatory pseudotumor, xanthogranuloma, plasma-cell granuloma, plasma-cell pseudotumor or an inflammatory myofibroblastic tumor. IMT commonly occurs in the lung, mesentery, omentum and retroperitoneum, but it may also be observed in the extremities, head and neck region, liver, spleen, thyroid, gastrointestinal tract, genitourinary tract and other systems (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The tumors usually follow a benign course, but recurrences have been documented in up to 25% of cases.…”