Inflammatory Pattern of the Bronchial Mucosa in Patients with Asthma with Airway Hyperresponsiveness to Hypoosmotic Stimulus

Pirogov, Alexey; Prikhodko, Anna; Perelman, Juliy M.; Zinovyev, Sergey; Afanasyeva, E. Yu.; Кolosov, Victor P.

doi:10.1007/s10517-016-3458-3

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…The percentage of neutrophils in the sputum of healthy controls ranges from 0-30% [28, 29], the etiology of which may be shear stress in the mucosa during the induction process, influence of specific resident microbiota or prior exposures to environmental agents. For example, higher sputum neutrophil counts were documented in ex-smokers [28].…”

Section: Obesity Smoking Gastroesophageal Reflux and Airway Neutropmentioning

confidence: 99%

Neutrophilic Inflammation in Asthma and Association with Disease Severity

Ray

Kolls

2017

Trends in Immunology

390

307

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Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of eosinophils and mast cells, and their role in the disease, have long been recognized, neutrophil infiltration has also been assessed in many clinical studies. In these studies, airway neutrophilia was associated with asthma severity. Importantly, neutrophilia also correlates with asthma that is refractory to corticosteroids, the mainstay of asthma treatment. However, it is now increasingly recognized that neutrophils are a heterogeneous population, and a more precise phenotyping of these cells may help delineate different subtypes of asthma. Here, we review the current knowledge on the role of neutrophils in asthma and highlight future avenues of research in this field.

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Section: Obesity Smoking Gastroesophageal Reflux and Airway Neutropmentioning

confidence: 99%

Neutrophilic Inflammation in Asthma and Association with Disease Severity

Ray

Kolls

2017

Trends in Immunology

390

307

View full text Add to dashboard Cite

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“…The percentage of neutrophils in the sputum of healthy controls ranges from 0% to 64% [ 16 , 17 ], the aetiology of which may be shear stress in the mucosa during the induction process, the influence of specific resident microbiota or prior exposures to environmental agents. Airway neutrophilia may be associated with pollution [ 18 ], smoking [ 19 ], workplace agents [ 20 ], acute infections [ 21 ], chronic airway infections ( e.g.…”

Section: Definition Of T2-low Asthmamentioning

confidence: 99%

Identification and treatment of T2-low asthma in the era of biologics

et al. 2020

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Currently, and based on the development of relevant biologic therapies, T2-high is the most well-defined endotype of asthma. Although much progress has been made in elucidating T2-high inflammation pathways, no specific clinically applicable biomarkers for T2-low asthma have been identified. The therapeutic approach of T2-low asthma is a problem urgently needing solution, firstly because these patients have poor response to steroids, and secondly because they are not candidates for the newer targeted biologic agents. There is, thus, an unmet need for the identification of biomarkers that can help the diagnosis and endotyping of T2-low asthmaOngoing investigation is focusing on neutrophilic airway inflammation mediators as therapeutic targets, including IL-8, IL-17, IL-1, IL-6, IL-23, TNF-a; molecules that target to restore corticosteroid sensitivity, mainly mitogen-activated protein kinase inhibitors, tyrosine kinase inhibitors and phosphatidylinositol 3-kinase inhibitors; PDE3 inhibitors that act as bronchodilators and PDE4 inhibitors that have an anti-inflammatory effect; and airway smooth muscle mass attenuation therapies, mainly for patients with paucigranulocytic inflammationThis manuscript aims to review the evidence for non-eosinophilic inflammation being a target for therapy in asthma, discuss current and potential future therapeutic approaches, such as novel molecules and biologic agents, and assess clinical trials of licensed drugs in the treatment of T2-low asthma.

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“…Usually, a bronchoscope is inserted into a specific lung of the bronchus, injected with saline at 37 ° C, and then aspirated under low negative pressure. Scanning microscopes use narrow focus and high-energy electron beams to scan samples [2]. The interaction between the beam and the substance stimulates various physical information, which is collected, enlarged and imaged to achieve the purpose of characterizing the microscopic morphology of the substance [3].…”

Section: Introductionmentioning

confidence: 99%

Scanning Microscopic Observation of Bronchial Mucosa Before and After Bronchoalveolar Lavage in Children with Acute Lower Respiratory Tract Infection

2020

IJHPM

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In recent years, the incidence of acute lower respiratory tract infections in children has gradually increased, seriously threatening children's lives and health. The emergence of bronchoalveolar perfusion therapy has brought good news and achieved good results. Therefore, it is very necessary to actively carry out scanning microscopy observation research on bronchoalveolar lavage based on bronchoalveolar lavage to treat children with acute lower respiratory tract infection. The purpose of this article is to investigate the bronchoalveolar lavage in the treatment of children with acute lower respiratory tract infection before and after bronchial mucosa scanning microscopy, a retrospective study of 120 children with acute lower respiratory tract infection, according to whether bronchoalveolar lavage is divided into control groups cases and 60 cases in the lavage group to observe changes in mucosal area and secretion content, respectively. The results of the study showed that the number of children with a bronchial mucosal surface reduction of more than 30% before and after surgery in the lavage group and the control group were 24 and 6, respectively, and the proportions were 40% and 10%, respectively. The number of children whose bronchial mucosal surface decreased by more than 0-30% before and after surgery in the lavage group and the control group were 27 and 31, respectively, and the proportions were 45% and 52%, respectively. It can be seen that the scanning microscope is important for the observation of bronchial mucosa before and after bronchoalveolar lavage treatment of children with acute lower respiratory tract infection.

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Inflammatory Pattern of the Bronchial Mucosa in Patients with Asthma with Airway Hyperresponsiveness to Hypoosmotic Stimulus

Cited by 3 publications

References 6 publications

Neutrophilic Inflammation in Asthma and Association with Disease Severity

Neutrophilic Inflammation in Asthma and Association with Disease Severity

Identification and treatment of T2-low asthma in the era of biologics

Scanning Microscopic Observation of Bronchial Mucosa Before and After Bronchoalveolar Lavage in Children with Acute Lower Respiratory Tract Infection

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