Inflammatory polyarthritis in mice transgenic for human t cell leukemia virus type i

Yamamoto, Hiroaki; Sekiguchi, Tatsuya; Itagaki, Keiko; Saijo, Shinobu; Iwakura, Yoichiro

doi:10.1002/art.1780361117

Cited by 43 publications

(20 citation statements)

References 25 publications

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“…This protein transactivates not only the viral long terminal repeat but also a variety of cellular genes, including interleukin-2 (IL-2), IL-2 receptor (IL-2 R), or other lymphokines (23)(24)(25). Thus, the transgenic mice carrying the HTLV-I tax genomes show chronic arthritis including erosive destruction of the bone, pannus formation, and lymphocytes infiltration resembling RA (11,12). Moreover, recent studies by Iwakura et al (13) demonstrated that the transgenic mice carrying HTLV-I env-tax region not only produce high levels of antibodies against IgG, collagen type II (IIC), heat shock protein (Hsp), and DNA, but also provide T cell proliferation to IIC and Hsp.…”

Section: Discussionmentioning

confidence: 99%

“…We administrated anti-Fas mAb (RK-8) to human T cell leukemia virus type I (HTLV-I) 1 tax transgenic mice. HTLV-I tax transgenic mice is considered to be one of the most suitable models for human RA, since these animals develop chronic synovitis and an immunological disorder resembling human RA (11)(12)(13). Our results demonstrated that intra-articular administration of anti-Fas mAb in these mice improved the paw swelling and histologic features of arthritis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

Fujisawa¹,

Asahara²,

Okamoto³

et al. 1996

J. Clin. Invest.

119

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

Fujisawa¹,

Asahara²,

Okamoto³

et al. 1996

J. Clin. Invest.

119

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“…Nerenberg (1990) described neurofibromas in HTLV-1 promoter (LTR)-Tax transgenic mice and used antisense inhibition of NF-kB to demonstrate its role in tumor growth. Lymphocytemediated arthropathy developed in Tax transgenic mice controlled through the HTLV-1 promoter (Iwakura et al, 1991(Iwakura et al, , 1995Yamamoto et al, 1993;Fujisawa et al, 1996). Increased levels of nerve growth factor, granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-2 receptor also developed in transgenic mice in which Tax was expressed from the human granzyme B promoter (GzmB) (Grossman and Ratner, 1997).…”

Section: Transgenic Modelsmentioning

confidence: 99%

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

2005

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Over the past 25 years, animal models of human T-lymphotropic virus type 1 (HTLV-1) infection and transformation have provided critical knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL). The virus consistently infects rabbits, some non-human primates, and to a lesser extent rats. In addition to providing fundamental concepts in viral transmission and immune responses against HTLV-1 infection, these models have provided new information about the role of viral proteins in carcinogenesis. Mice and rats, in particular immunodeficient strains, are useful models to assess immunologic parameters mediating tumor outgrowth and therapeutic invention strategies against lymphoma. Genetically altered mice including both transgenic and knockout mice offer important models to test the role of specific viral and host genes in the development of HTLV-1-associated lymphoma. Novel approaches in genetic manipulation of both HTLV-1 and animal models are available to address the complex questions that remain about viral-mediated mechanisms of cell transformation and disease. Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma Oncogene (2005) 24, 6005-6015.

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“…Genetically engineered mice expressing the tax gene of HTLV-I develop symptoms resembling Sjögren's Syndrome (SS) (Green et al, 1989). Transgenic mice expressing parts of the HTLV-I env and tax genes developed chronic inflammatory arthropathy resembling rheumatoid arthritis (Iwakura et al, 1991;Yamamoto et al, 1993). SS (autoimmune exocrinopathy) is among the systemic autoimmune diseases that share clinical symptoms with diseases induced by HIV.…”

Section: Introductionmentioning

confidence: 99%

Involvement of human intracisternal A‐type retroviral particles in autoimmunity

Sander

Szabo

Gallaher

et al. 2005

Microscopy Res & Technique

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Prior studies have linked retroviruses to various arthropathies and autoimmune diseases. Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by aggressive infiltration of lymphocytes into the salivary and lacrimal glands, resulting in destruction of the glands and dry mouth and eyes (sicca syndrome). The infiltrating lymphocytes in SS may become overtly malignant, and thus, the incidence of lymphoma is greatly increased in SS patients. A human intracisternal A-type retroviral particle type I (HIAP-I) has been isolated from persons with SS. HIAP-I shares a limited number of antigenic epitopes with human immunodeficiency virus (HIV), but is distinguishable from HIV by morphological, physical, and biochemical criteria. A substantial majority of patients with SS or systemic lupus erythematosus (SLE) have serum antibodies to the proteins of this human retrovirus. Fewer than 3% of the normal blood donor population have antibodies to any HIAP-associated proteins. A second type of a human intracisternal A-type retrovirus, HIAP-II, was detected in a subset of patients with idiopathic CD4 lymphocytopenia (ICL), an AIDS-like immunodeficiency disease. Most HIAP-II positive ICL patients were also antinuclear antibody positive. Reviewed here are additional studies from several laboratories suggesting that HIAP or related viruses may be involved in SLE and other autoimmune conditions. Additionally, results of comprehensive surveys of autoimmune patients to determine seroreactivity to HIAP, and other human retroviruses, including HIV and human T-lymphotropic virus type I, are reported.

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Inflammatory polyarthritis in mice transgenic for human t cell leukemia virus type i

Cited by 43 publications

References 25 publications

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

Involvement of human intracisternal A‐type retroviral particles in autoimmunity

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