Inflammatory profile in depression and associated clinical and sociodemographic features in a Middle-Eastern North-African population

Bahrini, L.; Ouanes, Sami; Ghachem, R.

doi:10.1016/j.jad.2016.03.036

Cited by 11 publications

(4 citation statements)

References 44 publications

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“…For example, they have been reported to have increased levels of IL-6 [99] [100, 101], IL-1β, and TNF [102]. A meta-analysis of 24 studies showed significantly higher concentrations of the proinflammatory cytokines TNF and IL-6 in depressed subjects compared with control subjects [103].…”

Section: Ar and Depressionmentioning

confidence: 99%

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Amritwar

Lowry

Brenner³

et al. 2017

Curr Treat Options Allergy

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Opinion Statement A high proportion of suicides visit their medical provider in the month prior to death, but depression, suicidal thoughts, and substance use are seldom addressed. For the clinicians routinely treating a substantial patient population with allergic diseases, there are additional concerns, as allergy has been linked with both depression and suicidal behavior. While psychotropic medications may affect diagnosis of allergies, medications used to treat allergies impact mood and behavior. Thus, we present an overview of the overlap of allergic rhinitis with depression and suicidal behavior in adults, based on clinical and epidemiological data, and our research and clinical experience. In summary, we suggest: 1) inquiring among patients with allergies about personal and family history of depression, substance use disorders, suicidal ideation and attempts 2) increased mindfulness regarding the potential effects of allergy medications on mood and behavior; and 3) for people identified with certain types of depression or increased suicide risk, a systematic multilevel collaborative approach. While for practical reasons the majority of patients with depression will continue to be treated by general or family practitioners, the allergy-treating provider should always consider integrated care for bipolar, psychotic or suicidal depression and incomplete remission, or relapsing and highly recurrent course. While awaiting results of much needed basic and clinical research to guide clinical approach for patients with comorbid allergic rhinitis and depression, the simple steps recommended here are expected to improved clinical outcomes in depression, including, on a large scale, reduced premature deaths by suicide.

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Section: Ar and Depressionmentioning

confidence: 99%

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Amritwar

Lowry

Brenner³

et al. 2017

Curr Treat Options Allergy

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“…Mental disorders following TBI are often accompanied by changes in immune function and activation of the in ammatory response system [12,13] However, the causality between in ammation and depression remains controversial [43] Importantly, both may mutually promote each other. In ammation may promote the onset of depression [44,45] , and depression can exacerbate in ammation [46] Patients with depression often present abnormal expression of in ammatory cytokines, hindering recovery from TBI and prolonging treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The underlying mechanisms of mental disorders after TBI are complex, but current hypotheses suggest disruptions in neuroendocrine regulation, abnormalities in hypothalamic-pituitary-adrenal (HPA) axis activity, and dysfunctions in central nervous system (CNS) neurotransmission [12,13] The HPA axis is a major pathway involved in the development of psychiatric symptoms [31][32][33][34] , with abnormal activation and changes in cortisol levels being important characteristics of patients with mental disorders [35][36][37] Dysfunction in CNS 5-HT neurotransmission has been implicated in emotional disorders [38,39] , with anxiety and depression patients presenting signi cantly reduced 5-HT levels. Meanwhile, cortisol, adrenaline, and noradrenaline levels are also decreased [40,41] Dopamine neurons are also closely related to mental disorders after TBI, as they are easily damaged, leading to decreased dopamine function and levels in patients with mental disorders [42] Our study found that out of 67 patients, 43 had varying degrees of depression, and depressed patients had signi cantly lower 5-HT levels than non-depressed patients.…”

Section: Discussionmentioning

confidence: 99%

“…The detailed mechanism of the high incidence of psychiatric disorders after TBI is not yet clear, and the main hypothesized mechanisms involve neuroendocrine disorders and abnormal activity in the hypothalamic-pituitary-adrenal axis (HPA) [12,13]. Previous studies have reported that the occurrence of psychiatric disorders is usually accompanied by changes in immune function, activation of the in ammatory response system, and decreased levels of brain-derived neurotrophic factor (BDNF) [14][15][16], all of which are detrimental to TBI recovery.…”

Section: Introductionmentioning

confidence: 99%

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Identifying Factors Associated with Post-Traumatic brain injury Depression: The Role of Inflammatory Markers

Yang,

王,

Liu

et al. 2024

Preprint

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Background Depression is a common emotional and psychiatric complication of traumatic brain injury (TBI) that has significant negative impacts on patient recovery. Despite the importance of identifying and treating depression in TBI patients, there is currently no simple and standardized system available for assessing the likelihood of post-TBI depression. In this study we are aim to explore the clinical value of peripheral blood inflammatory markers in predicting mental disorders after TBI. Methods A total of 67 TBI patients in this study were included and divided them into Group A (depression group) or Group B (non-depression group) based on the presence or absence of concomitant psychiatric disorders. We collected relevant clinical data and inflammatory markers from both groups to identify factors influencing post-TBI depression and analyzed their diagnostic efficacy and correlations. Results The overall prevalence of mental disorders among TBI patients was found to be 64.18% at the three-month follow-up after injury. Our study revealed that intracranial infection was an independent factor influencing the occurrence of post-TBI depression (OR = 19.873, 95%CI = 6.721 ~ 58.764, P = 0.001). Patients who developed post-TBI depression had significantly higher levels of white blood cells(WBCs), neutrophil percentage, C-reactive protein (CRP), and monocyte levels compared to non-depressed TBI patients. Additionally, WBCs (Pearson = 0.735,P = 0.001), neutrophil percentage (Pearson = 0.742, P = 0.001), and CRP (Pearson = 0.556, P = 0.001) levels were positively correlated with depression severity in TBI patients. Conclusions Our findings suggest a high prevalence of post-TBI depression and highlight peripheral inflammatory markers such as WBCs, neutrophil percentage, and CRP levels as potential early diagnostic indicators for this condition. Identifying these factors can facilitate early diagnosis and intervention for post-TBI depression, improving patient outcomes. This study provides evidence for clinicians to develop effective treatment strategies for post-TBI depression and advance our understanding of its mechanisms.

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L’asse dello stress: regolazione neuro-endocrino-immuno-metabolica e ruolo nello sviluppo della sindrome metabolica e della depressione

Lombardo,

Belcastro,

Mondelli

et al. 2023

L'Endocrinologo

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SommarioLo stress rappresenta la risposta di adattamento dell’organismo a una minaccia all’equilibrio (omeostasi) dell’organismo da parte di eventi o stressor di natura intrinseca o estrinseca, reali o percepiti. Gli stressor attivano un variegato e intricato repertorio di risposte fisiologiche biologiche e comportamentali (allostasi) volte a ristabilire l’equilibrio ottimale dell’organismo (eustasi). La risposta adattiva agli stressor dipende da una complessa rete psico-neuro-endocrino-immuno-metabolica, cellulare e molecolare altamente interconnessa, chiamata proprio sistema o asse dello stress. I componenti chiave sono rappresentati dall’asse ipotalamo-ipofisi-surrene (HPA) e dal sistema nervoso autonomo (SNA), che interagiscono con altri centri vitali del sistema nervoso centrale (SNC) e con organi periferici e sistemi, dalla cui attivazione complessiva si genera una risposta rapida, efficace, multisistemica e autolimitantesi, che permette all’organismo una reazione corporea e neuropsichica ottimale. Le catecolamine e il cortisolo rappresentano gli attori principali che esplicano e attivano le reazioni psichiche e comportamentali dell’individuo nella reazione di stress, la cosiddetta reazione fight or flight. L’azione delle catecolamine è breve, quella del cortisolo più duratura e mediata dall’attivazione dei recettori del cortisolo (GR e MR, recettori dei glucocorticoidi e mineralcorticoidi rispettivamente) espressi ubiquitariamente. Attraverso azioni non genomiche e genomiche i glucocorticoidi modulano una serie di processi metabolici, con caratteristiche sesso specifiche. Una delle conseguenze della reazione dello stress, in condizioni in cui quest’ultimo sia persistente o non adeguatamente regolato, è lo sviluppo di uno stato infiammatorio cronico. Il cortisolo ha un ruolo rilevante nell’equilibrio citochinico pro/antinfiammatorio. In condizioni di stress cronico questo equilibrio viene meno e si crea uno scenario caratterizzato da risposte infiammatorie eccessive. È oggi definito il ruolo dello stato infiammatorio cronico nella fisiopatologia della sindrome metabolica, dell’obesità e del diabete, così come della depressione. In questa rassegna percorreremo, sulla base delle evidenze della letteratura, i meccanismi psico-neuro-endocrino-metabolici sottesi alla regolazione dello stress e alle conseguenze metaboliche e psichiche potenzialmente generabili e correlate allo stress cronico o all’alterata regolazione dello stesso.

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Inflammatory profile in depression and associated clinical and sociodemographic features in a Middle-Eastern North-African population

Cited by 11 publications

References 44 publications

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Identifying Factors Associated with Post-Traumatic brain injury Depression: The Role of Inflammatory Markers

L’asse dello stress: regolazione neuro-endocrino-immuno-metabolica e ruolo nello sviluppo della sindrome metabolica e della depressione

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