A case of plasma cell granuloma of the stomach in a 33‐year‐old man, surgically treated as an advanced carcinoma of the cardia, is reported. Histologically, the lesion is of nonneoplastic nature and appears to be inflammatory in origin with unknown etiologic causes. The histologic and pathogenetic differences of this particular lesion from plasmacytoma are especially emphasized. It is considered that plasma cell granuloma may well be classified into one of the sub‐types of the postinflammatory pseudotumor. The patient has been followed, and no clinical evidence of recurrent disorder for 2 years postoperatively has been observed.