Inflammatory pseudotumors of the lung in children: Conservative or aggressive approach?

Messineo, Antonio; Mognato, Guendalina; dʼAmore, Emanuele S.G.; Antoniello, Luca Maria; Guglielmi, M; Cecchetto, Giovanni

doi:10.1002/(sici)1096-911x(199808)31:2<100::aid-mpo10>3.0.co;2-r

Cited by 28 publications

(16 citation statements)

References 14 publications

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“…The most appropriate surgical approach (such as use of the wedge resection, lobectomy, and pneumonectomy) depends on the specific dimension and tumor localization, its relationship with the surrounding structures and the surgical equipment experience ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Inflammatory Myofibroblastic Tumor in Children: A Case Report and Brief Review of Literature

et al. 2018

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The inflammatory myofibroblastic tumor (IMT) is a rare lesion of unclear etiology and variable clinical course, consisting of a proliferation of fibroblasts and myofibroblasts, mixed with inflammatory cells. Synonyms of IMT are inflammatory pseudotumor and plasma cell granuloma reflecting the alleged inflammatory nature attributed to this lesion, even though this heterogeneity in the disease denomination is probably involved in a dispersion of the literature data. Among primary pulmonary neoplasms, it represents the most frequent endobronchial tumor of childhood and beyond the lung it has been described mainly in the bladder, mediastinum and mesentery. Despite having a tendency for local recurrence, the risk of distant metastasis is low. Clinical presentation depends on localization therefore lung peripheral lesions are often asymptomatic resulting in a delayed diagnosis. Radiological findings can suggest the diagnosis that must be confirmed by histopathology assessment. The tumor has been characterized by the application of immunohistochemical techniques, molecular biology and cytogenetics, which are very precious for the diagnosis. The therapeutic approach consists in the complete surgical excision of the lesion that normally ensures excellent survival. Due to the potential risk of recurrence, close clinical trial is indicated. To date only 24 cases of pulmonary IMT have been described, although the prevalence is probably higher. We present a case report of a 3-year-old girl with pulmonary IMT and a brief review of known literature cases in order to highlight the most common clinical presentations, the most useful diagnostic tools and therapeutic approach.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Inflammatory Myofibroblastic Tumor in Children: A Case Report and Brief Review of Literature

et al. 2018

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“…19 The prognosis of patients with completely resected inflammatory pseudotumors is excellent: 78% to 100% of patients were in complete remission after an average follow-up of 3.3 years after surgical resection. 14,17,20 Intrathoracic recurrence was seen in 5% of cases.…”

Section: Figurementioning

confidence: 99%

Pulmonary Inflammatory Pseudotumor (Inflammatory Myofibroblastic Tumor)

Kim¹,

Han²,

Kim³

et al. 2005

Journal of Computer Assisted Tomography

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The objective of this study was to assess the CT features of pulmonary inflammatory myofibroblastic tumors with pathologic correlation. The authors retrospectively reviewed CT and pathologic findings of 10 patients with surgically resected inflammatory myofibroblastic tumor of the lung. On CT, five patients showed a polypoid endotracheal (n = 3) or endobronchial nodule in the left main bronchus (n = 2). Two patients showed a central parenchymal mass, and the remaining three patients showed a peripheral pulmonary nodule. All tumors had well defined margins and were round to ovoid; they ranged in diameter from 13 to 52 mm and showed varying degrees of contrast enhancement (range 13-89 H). On histopathologic examination, the two central parenchymal masses involving segmental bronchi were also mainly endobronchial in location. The three peripheral pulmonary nodules also showed a peribronchiolar location, with a bronchial mucosal lining spared in part. The authors conclude that pulmonary inflammatory myofibroblastic tumors are closely related to the airway.

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“…2 The current treatment approach to inflammatory pseudotumors of the lung is total resection of the lung lesion, resulting in total cure with minimal risk of recurrence. 3 Although total excision is preferred, it may not be possible for large inflammatory pseudotumors of the lung, for which complete removal of the mass requires a drastic pneumonectomy. For this category of large inflammatory pseudotumors of the lung, treatment options remain limited.…”

Section: Introductionmentioning

confidence: 99%

Successful treatment of unresectable inflammatory pseudotumor of the lung with COX‐2 inhibitor

Chan

Omar

Ramanujam

2003

Pediatric Pulmonology

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Inflammatory pseudotumors of the lung in children: Conservative or aggressive approach?

Cited by 28 publications

References 14 publications

Pulmonary Inflammatory Myofibroblastic Tumor in Children: A Case Report and Brief Review of Literature

Pulmonary Inflammatory Myofibroblastic Tumor in Children: A Case Report and Brief Review of Literature

Pulmonary Inflammatory Pseudotumor (Inflammatory Myofibroblastic Tumor)

Successful treatment of unresectable inflammatory pseudotumor of the lung with COX‐2 inhibitor

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