Inflammatory Response to Metals and Ceramics

Pizzoferrato, Alberto; Cenni, E.; Ciapetti, G.; Granchi, Donatella; Savarino, L.; Stea, Susanna

doi:10.1007/0-306-47583-9_26

Cited by 13 publications

(13 citation statements)

References 174 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That Cr and Al ions are not particularly toxic to cells/ tissues is well known. 41 In a recent study using both primary and established cells Cr and Al are classified as "moderately to mildly toxic" for osteoblasts, as some effects on cells were assessed at a concentration around 5mM. 42 Our results confirm that osteoblast-like cells can easily bear ion release from ALUSI alloys.…”

Section: Discussionsupporting

confidence: 62%

Potential of FeAlCr intermetallics reinforced with nanoparticles as new biomaterials for medical devices

et al. 2006

View full text Add to dashboard Cite

Novel FeAlCr oxide dispersion strengthened intermetallics that are processed by powder metallurgy have been developed as potential biomaterials. The alloys exhibit a small grain size and a fine dispersion of yttria provides the material with a high yield strength and depending on the alloy composition good ductility (up to 5%). The biocompatibility of the alloy was assessed in comparison with commercial alumina. Saos-2 osteoblast-like cells were either challenged with mechanically alloyed particles, or seeded onto solid samples. Viability and proliferation of cells were substantially unaffected by the presence of a high concentration of particles (1 mg/mL). Solid samples of novel FeAlCr intermetallic have shown a good biocompatibility in vitro, often approaching the behavior of materials well known for their biological acceptance (e.g. alumina). It has been found that osteoblasts are able to produce ALP, a specific marker of cells with bone-forming activity. In this respect, ALUSI alloys hold the promise to be suitable substrate for bone integration. The finding of no cytotoxic effect in the presence of the alloy particles is a reliable proof of the absence of acute toxicity of the material.

show abstract

Section: Discussionsupporting

confidence: 62%

Potential of FeAlCr intermetallics reinforced with nanoparticles as new biomaterials for medical devices

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Fibroblasts are widely accepted for cytotoxicity testing [27] and used as a standard cell type in order to determine the general biocompatibility of materials. To assess cy- totoxicity, hydrogels consisting of 2 % (w/v) 4armPEG10k-SPA and 2 % (w/v) 4armPEG10k-NH 2 were evaluated by a medium extraction test.…”

Section: Cytotoxicity Of Cross-linked Hydrogelsmentioning

confidence: 99%

Poly(Ethylene Glycol) Based Hydrogels for Intraocular Applications

et al. 2007

View full text Add to dashboard Cite

Hydrogels are attractive materials for biomedical applications due to their versatility and excellent biocompatibility. In this study, we report the preparation of poly(ethylene glycol) (PEG) based hydrogels for intraocular applications. We synthesized branched PEG‐succinimidyl propionates (10 kDa molecular weight) and different types of PEG‐amines (linear and branched, 2 and 10 kDa molecular weight). Transparent hydrogels were formed in situ upon chemical reaction of these macromers. The gels were characterized by oscillatory rheometry and NMR experiments. By varying the concentration of macromers, the functionality of the PEG‐amine, and the conditions during cross‐linking, gels with adequate gelation times of approx 5–10 min and gel strengths of approx 350–1500 Pa were obtained. The cross‐linked hydrogels showed no cytotoxic effects and may be used as vitreous substitutes or intraocular drug release systems.

show abstract

“…The establishment of a load bearing biomaterial must be incorporated with natural bone. The implanted biomaterial should possess the following criteria: biocompatibility, osteoconductivity, high porosity and biomechanical compatibility [ 1 ]. For this requirement, autografts and allografts are used extensively for bone grafts.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Composites for Bone Tissue Engineering—An Overview

2010

View full text Add to dashboard Cite

Bone contains considerable amounts of minerals and proteins. Hydroxyapatite [Ca10(PO4)6(OH)2] is one of the most stable forms of calcium phosphate and it occurs in bones as major component (60 to 65%), along with other materials including collagen, chondroitin sulfate, keratin sulfate and lipids. In recent years, significant progress has been made in organ transplantation, surgical reconstruction and the use of artificial protheses to treat the loss or failure of an organ or bone tissue. Chitosan has played a major role in bone tissue engineering over the last two decades, being a natural polymer obtained from chitin, which forms a major component of crustacean exoskeleton. In recent years, considerable attention has been given to chitosan composite materials and their applications in the field of bone tissue engineering due to its minimal foreign body reactions, an intrinsic antibacterial nature, biocompatibility, biodegradability, and the ability to be molded into various geometries and forms such as porous structures, suitable for cell ingrowth and osteoconduction. The composite of chitosan including hydroxyapatite is very popular because of the biodegradability and biocompatibility in nature. Recently, grafted chitosan natural polymer with carbon nanotubes has been incorporated to increase the mechanical strength of these composites. Chitosan composites are thus emerging as potential materials for artificial bone and bone regeneration in tissue engineering. Herein, the preparation, mechanical properties, chemical interactions and in vitro activity of chitosan composites for bone tissue engineering will be discussed.

show abstract

Inflammatory Response to Metals and Ceramics

Cited by 13 publications

References 174 publications

Potential of FeAlCr intermetallics reinforced with nanoparticles as new biomaterials for medical devices

Potential of FeAlCr intermetallics reinforced with nanoparticles as new biomaterials for medical devices

Poly(Ethylene Glycol) Based Hydrogels for Intraocular Applications

Chitosan Composites for Bone Tissue Engineering—An Overview

Contact Info

Product

Resources

About