Inflammatory status in patients with chronic renal failure: The role of PTX3 and pro-inflammatory cytokines

Malaponte, Grazia; Libra, Massimo; Bevelacqua, Ylenia; Merito, Paola; Fatuzzo, Pasquale; Rapisarda, Francesco; Cristina, María; Naselli, Gabriele; Stivala, F; Mazzarino, María Clorinda; Castellino, Pietro

doi:10.3892/ijmm.20.4.471

Cited by 29 publications

(28 citation statements)

References 77 publications

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“…Other studies have shown that PTX-3 has a more stable course (16), relation between CRP and PTX-3 is weak (8,12), PTX-3 is related with IL-6 more strongly than CRP (15) and the relationship between IL-6 levels and cardiovascular disease risk is stronger (2). From our findings, together with these literature data, it may be said that PTX-3 is superior to CRP as an inflammation marker.…”

Section: Discussionsupporting

confidence: 73%

Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients?

et al. 2012

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Pentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers of inflammation in peritoneal dialysis (PD) patients. Non-diabetic patients on chronic PD program who meet the dialysis adequacy criteria and who had no active infectious/inflammatory disease were included. Demographic and clinical parameters were recorded as well as hsCRP, fibrinogen, interleukin-6 (IL-6) and PTX-3 levels; and the correlation between them were studied. Twenty-five patients (mean age: 45.7±12.5 years; female/male ratio: 16/9) were included. Mean PTX-3 level was 2.16±2.76ng/ml. PTX-3 was found to be correlated positively with only IL-6 among inflammatory markers (r=0.827; p<0.001) but not with hsCRP. With linear regression model, IL-6 was the only independent determinant of PTX-3 levels. PTX-3 may be a more valuable marker of inflammation than CRP in patients on PD.

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Section: Discussionsupporting

confidence: 73%

Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients?

et al. 2012

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“…[15][16][17] In addition, PTX-3 may have a more stable course than CRP. 18 Cytokines, complement components, and fibrinolytic agents are released with the ischemia-reperfusion injury that occurs during transplant. 19 However, the effects of PTX-3 during this injury have not been studied sufficiently.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Gürsu

Çelik²,

Öztürk³

et al. 2014

Exp Clin Transplant

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Objectives: There are numerous changes in inflammatory status that occur after a kidney transplant. Pentraxin 3 is a marker of inflammation, but little information is available about pentraxin 3 levels after a kidney transplant. We evaluated the relation between pentraxin 3 and other inflammatory markers including high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor α in kidney transplant recipients. Materials and Methods: Adult patients (40 patients; aged, 18-80 y; mean age, 38 ± 10 y) who had a kidney transplant from living-related donors were studied. Patients who had comorbidities associated with chronic inflammation were excluded. Blood samples were obtained before starting immunosuppressive treatment and 2 months after kidney transplant for measurement of pentraxin 3, high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor α levels. Results: After transplant, mean levels of high sensitivity C-reactive protein and interleukin 6 decreased but levels of pentraxin 3 and tumor necrosis factor α did not change. There were significant correlations between interleukin 6 and high sensitivity C-reactive protein before transplant (r = 0.71; P ≤ .0001) and after transplant (r = 0.45; P ≤ .003). There was no correlation between tumor necrosis factor α and high sensitivity C-reactive protein before transplant, but there was a significant correlation between tumor necrosis factor α and high sensitivity C-reactive protein after transplant (r = 0.36; P ≤ .03). There was no correlation between interleukin 6 and pentraxin 3, tumor necrosis factor α and pentraxin 3, or high sensitivity C-reactive protein and pentraxin 3 before or after transplant. Conclusions: After a kidney transplant, pentraxin 3 may not be useful in determining inflammatory status, and high sensitivity C-reactive protein may be better than pentraxin 3 as a marker of inflammation.

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“…Tong et al (6) found that the relation between IL-6 and PTX-3 was stronger than that between IL-6 and CRP. It has been shown by previous studies that PTX-3 has a more stable course (20). It was shown to be weakly correlated with CRP (13,21), while more closely related with IL-6 (6).…”

Section: Discussionmentioning

confidence: 99%

“…It is regarded as an independent marker of disease activity due to its synthesis directly at the site of inflammation. Uremic patients have high PTX-3 levels, which are related with increased mortality independent of CRP (6,19); it has a more stable course than CRP (20). The relationship of PTX-3 with CRP has been reported to be weak in some studies (13,21).…”

Section: Introductionmentioning

confidence: 99%

Is Pentraxin-3 a Stronger Marker of Inflammation than C-Reactive Protein in Chronic Kidney Disease?

Gürsu¹,

Aydın²,

Öztürk³

et al. 2014

Turk Neph Dial Transpl

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ObJeCtIve: Pentraxin-3 (PTX-3) is elevated in uremic patients and related with albuminuria and endothelial dysfunction. We aimed to clarify the relationship of PTX-3 with inflammatory markers (hsCRP and IL-6) in patients with chronic kidney disease (CKD). MAterIAl and MetHOdS:The study was performed with four groups: hemodialysis (HD) group (23 patients), peritoneal dialysis (PD) group (25 patients), predialysis group (stage-4 CKD, 25 patients) and the healthy control group (18 individuals). GFR was estimated by the MDRD formula. PTX-3, IL-6, fibrinogen, hsCRP levels, glucose, urea, creatinine, uric acid, parathyroid hormone, albumin, LDL cholesterol, HDL cholesterol, triglyceride, ferritin, and hemoglobin were studied from the serum and whole blood samples.reSUltS: PTX-3 levels were highest in the HD group followed by the PD group, pre-dialysis group and control group (3.58±4.29, 2.15±2.75, 1.29±2.36, 0.73±0.96 ng/ml, respectively). IL-6 levels were highest in the PD group followed by the HD, predialysis and control groups. There was no difference between groups regarding hsCRP levels. There was no correlation of PTX-3 with hsCRP, while it was correlated with IL-6. IL-6 was the only determinant of PTX-3 level independent of the study groups and vice versa.COnClUSIOn: Uremic patients have elevated PTX-3 levels and it is strongly correlated with IL-6. PTX-3 may be superior to CRP as an inflammation marker in the uremic population.

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Inflammatory status in patients with chronic renal failure: The role of PTX3 and pro-inflammatory cytokines

Cited by 29 publications

References 77 publications

Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients?

Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients?

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Is Pentraxin-3 a Stronger Marker of Inflammation than C-Reactive Protein in Chronic Kidney Disease?

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