Inflammatory symptoms in breast cancer. Correlations with growth rate, clinicopathologic variables, and evolution

Abstract

Based on two pretreatment evaluations, doubling time (DT) was calculated in 75 cases of invasive breast cancer (BC). The cases studied were more or less equally distributed between three DT groups: fast-growing tumors (DT < 90 days), intermediate cases (DT between 90 and 180 days), and slow-growing tumors (DT > 180 days). A correlation was found to exist between DT and patient age and, to an even greater extent, between DT and pathologic prognostic indicators such as histologic grading and nuclear grade. Inflammatory symptoms were not associated with DT, but were closely related to the size of the tumor and regional lymph node involvement. The date of detection of distant metastases depended heavily on the DT of the BC : BC with shorter DT = earlier metastatic spread. The presence of inflammatory signs was also decisive: within each DT category, inflammatory BC metastases were both more frequent and precocious. Cancer 642081-2089. 1989.

Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients

“…This phenomenon is common in women from Arab countries. About 28% of breast cancer patients in Egypt report seeking medical care no earlier than 6 months after their observation of a breast mass or lymph node enlargement [20][21]. This tendency to delay medical care may bias the estimate of disease duration for IBC patients in Egypt and may influence the correlation between clinical and molecular phenotypes.…”

Trends for Inflammatory Breast Cancer: Is Survival Improving?

“…IBC is a clinical diagnosis characterized by the presence of symptoms and signs such as erythema, tenderness, edema, pain, and rarely, ulceration that rapidly extend to the entire breast [4,5]. Pathologically, IBC is frequently diagnosed by the presence of cancer cells penetrating dermal lymphatic channels causing the inflammatory signs [6].…”

p53 Expression as a Prognostic Marker in Inflammatory Breast Cancer

“…IBC is a clinical diagnosis characterized by the presence of symptoms and signs such as erythema, tenderness, edema, pain, and ulceration that rapidly extend to the entire breast (4,5). Pathologically, IBC is frequently diagnosed by the presence of cancer cells penetrating dermal lymphatic channels ( Fig.…”