Influence du tabagisme chronique sur les leucocytes

Vanuxem, D.; Sampol, J.; Weiller, Pierre‐Jean; M’Barki, M.; Grimaud, C

doi:10.1159/000194697

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…38 We confirmed the previously reported increase in total leucocyte blood counts and the size of the increase in smokers compared with non-smokers [6][7][8][9][10][11][12][13][14][15] and the negative relation between the total leucocyte blood count and lung function in smokers. [15][16][17][18][19] The total leucocyte blood counts independently accounted for about 3% of the variation of FEV 1 residuals and this eVect of leucocytes on lung function makes this figure unsuitable for predicting accelerated loss of lung function in smokers.…”

Section: Discussionsupporting

confidence: 90%

Prospective study on the effect of smoking and nicotine substitution on leucocyte blood counts and relation between blood leucocytes and lung function

Jensen

Pedersen

Frederiksen

et al. 1998

Thorax

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Background-The influence of smoking and of nicotine substitution on the counts of total blood leucocytes and leucocyte subsets and the relations between the counts and lung function was investigated. Methods-The study was a combined cross sectional and prospective study of 298 smokers and 136 non-smokers. Forced expiratory volume in one second (FEV 1 ) was measured in all participants at baseline and six months after quitting smoking in 160 ex-smokers (quitters) and 138 persons with smoking relapse. Blood samples were obtained from all participants at baseline and from 160 quitters and 30 continuing smokers two, six, 12, and 26 weeks after smoking cessation and from 92 quitters one year after the cessation of smoking. Results-Blood leucocyte counts and leucocyte subsets were all higher in smokers than in non-smokers. In cigarette smokers total leucocyte, neutrophil, and lymphocyte blood counts showed a dose dependent relationship with the daily cigarette consumption and pack years consumption. In smokers the neutrophil blood count was independently associated negatively with FEV 1 residuals. After quitting smoking total leucocyte, neutrophil, and lymphocyte blood counts decreased during the first 26 weeks and after one year lymphocyte blood counts were higher than in non-smokers. In quitters substituted with nicotine chewing gum (2 mg) the accumulated number of pieces of chewing gum used in the 12 weeks had an inverse relationship with the decrease in the total lymphocyte blood count at 12 weeks after smoking cessation. Conclusions-Leucocyte blood counts are raised in smokers and decrease after smoking cessation. Neutrophil blood counts had an inverse relationship with lung function and nicotine may increase lymphocyte blood counts in smokers. (Thorax 1998;53:784-789)

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Section: Discussionsupporting

confidence: 90%

Prospective study on the effect of smoking and nicotine substitution on leucocyte blood counts and relation between blood leucocytes and lung function

Jensen

Pedersen

Frederiksen

et al. 1998

Thorax

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“…The absolute number of T cells and surface IgG-bound B lymphocytes was also increased in smokers in accordance with the literature [21,22], In the present study we have demonstrated a higher number of spleen cells in mice kept in cigarette smoke, an increase which was more definite calculating the cell number per milligram spleen. This alteration in the number of immunocompe tent cells might be connected with the irritat ing effect of tobacco smoke, inducing chronic inflammations and sometimes allergic reac tions; this may contribute to the increase of various immunoglobulin levels, too.…”

Section: Discussionsupporting

confidence: 93%

Effect of Cigarette Smoke and 2-Mercaptoethanol Administration on Age-Related Alterations and Immunological Parameters

Beregi¹,

Regius²,

Rajczy³

et al. 1991

Gerontology

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In old CBA/Ca mice the effect of cigarette smoke was compared with that of 2-mercaptoethanol (2-ME) treatment. It could be stated that spontaneous death was more frequent in animals kept in cigarette smoke than in the control animals. Prevalence of hepatocellular carcinoma was higher in animals kept in cigarette smoke than in the controls. After 2-ME treatment the occurrence of hepatocellular carcinoma was significantly lower and animals without disorders were more frequent than in smokers. Body weights were lower in animals kept in cigarette smoke and differences in organ indices could be observed, too. Immunological changes were also demonstrated: in mice kept in cigarette smoke the reactivity against a foreign antigen such as sheep erythrocytes (SRBC) was lower, while after 2-ME treatment it was higher than in their controls using direct plaque formation technique. The ratio of normal reactivity (against SRBC) and autoreactivity (against mouse erythrocytes) showed a decrease in smoker animals, and an increase in the 2-ME-treated ones. The experiments showed a deleterious effect of cigarette smoke and a beneficial effect of 2-ME on age-related alterations.

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“…The number of cigarettes consumed on the test day was 7 (0-8), and the time between smoking the last cigarette and providing the breath and blood samples was 1.0 (0. [6][7][8][9][10][11][12][13][14] hours.…”

Section: Resultsmentioning

confidence: 99%

Plasma nicotine concentration and the white blood cell count in smokers.

Taylor¹,

Woodman²,

Clarke³

1986

Thorax

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The peripheral blood total white cell count is 20-25% higher in smokers than in non-smokers (for review see ref 1). Smoking probably causes the increase in white cell count. Thus the count is higher in those who smoke and inhale more,2 while a change in cigarette consumption is associated with a corresponding change in white cell count, and giving up smoking with a reduction in the count.3 Despite this evidence, the way in which smoking raises the white cell count is unknown. This study was conducted to determine if the white cell count in smokers is related to the concentration of nicotine in plasma or of carbon monoxide in end expired air. MethodsTwenty two healthy young men of European extraction employed in the hospital were studied. None took any medication or had abnormal spirometric values. Twelve were regular cigarette smokers (median age 22 years) and 10 were lifelong non-smokers (median age 23.5 years). All gave written consent to be studied, and the ethics committee approved the study.The subjects were studied between 2.35 and 4.40 pm. Exercise beforehand was prohibited but smokers were allowed to smoke as usual, except during the half hour before the samples of blood and expired air were taken, when all the subjects remained seated quietly. Samples of end expired air were obtained after a 20 second breath hold following maximal inspiration, and end expired carbon monoxide concentration was measured at once with an Ecolyzer 2000 series analyser (Energetics Science). A peripheral venous blood sample was taken immediately after the breath sample. The white cell count was measured with an ELT-800 automated whole blood analyser (Ortho Diagnostic Systems Inc), and plasma nicotine concentration by gas chromatography (smokers only). Correlation was determined with Spearman's rank coefficient, and a p value of < 0.05 was regarded as significant. ResultsIn smokers the median (range) duration of smoking was 6 (3-19) years, and usual daily consumption 18 (3-25) cigarettes. The number of cigarettes consumed on the test day was 7 (0-8), and the time between smoking the last cigarette and providing the breath and blood samples was 1.0 (0.6-14)hours.Address for reprint requests: Dr RG Taylor, Department of Thoracic Medicine, Royal Free Hospital, London, NW3 2QG. Accepted 5 November 1985The median (range) plasma nicotine concentration was 1 1.2 (0.1-36.8) ng/ml in the smokers, and that of end expired carbon monoxide concentration 25 (6-42) ppm in the smokers and 4.0 (3.5-4.5) ppm in the non-smokers. Plasma nicotine and end expired carbon monoxide concentrations were significantly correlated in smokers (r, = 0.91, p < 0.001).The mean (SD) white cell count was 7.37 (1.39) x 109/1 in the smokers and 6.73 (1.17) x 109/1 in the non-smokers. The white cell count was significantly related to the plasma nicotine concentration in smokers (r. = 0.58, p < 0.05), but not to cigarette consumption on the test day or on usual days, or to end expired carbon monoxide concentration in smokers or non-smokers. DiscussionThis study discl...

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Influence du tabagisme chronique sur les leucocytes

Cited by 14 publications

References 24 publications

Prospective study on the effect of smoking and nicotine substitution on leucocyte blood counts and relation between blood leucocytes and lung function

Prospective study on the effect of smoking and nicotine substitution on leucocyte blood counts and relation between blood leucocytes and lung function

Effect of Cigarette Smoke and 2-Mercaptoethanol Administration on Age-Related Alterations and Immunological Parameters

Plasma nicotine concentration and the white blood cell count in smokers.

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