Influence of 1B ischemic ventricular tissue on the automaticity of Purkinje fibers: A simulation study

Abstract

A computer model has been developed to study the electrical activity of a Purkinje fiber of 1.5 cm coupled to a regionally 1B ischemic ventricular fiber of 3 cm through a Purkinje-muscle resistance (R pvj

Non-Uniform Dispersion of the Source-Sink Relationship Alters Wavefront Curvature

“…Other theoretical works have also used the SF to study cardiac propagation and block. Indeed, the SF has been used to gain insights into the mechanisms of conduction on very slow propagation during reduced excitability and decreased gap junction coupling [8] , to determine the kinetics and contributions to the propagation process of I Na and I CaL in the heterogeneous regions [9] , to study the importance of obstacle composition and geometry in wavefront interactions with cardiac obstacles [14] , to analyze the SF for cardiac propagation in cases of branching [13] , in PVJ [12] , [15] , [16] or in the atrial pectinate muscle [27] and to study the effects of the increase of the effective interstitial resistivity [17] .…”

“…The SF has been used to theoretically investigate the ionic mechanisms of cardiac propagation and arrhythmias under different conditions, such as slow conduction and conduction path branching in the heart [8] , [13] , reentry generation [11] , wavefront-obstacle interactions [14] , conduction through the Purkinje-ventricular junction (PVJ) [12] , [15] , [16] and in cardiac tissues with microstructural variations [17] . Here, to gain insights into the mechanisms of wavefront conformation we improve our previous SF formulation and we use it to characterize the source-sink relationship of excitatory waves in a 2D tissue.…”