In a defined setting of ischaemia (phase 1B), a small amount of uncoupling between ventricular cells, as well as between Purkinje and ventricular tissue, may induce UDBs and reentry. Hyperkalaemia is also confirmed to be an important factor in the genesis of reentrant rhythms, since it regulates the range of coupling in which UDBs may be induced.

A computer model has been developed to study the electrical activity of a Purkinje fiber of 1.5 cm coupled to a regionally 1B ischemic ventricular fiber of 3 cm through a Purkinje-muscle resistance (R pvj

Abstract

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