Influence of a remote oh group on the stability of the phosphoramide bond in an ester of uridylyl(5′→N)alanine

Smirnov, V. D.; Shinskii, N. G.; Shabarova, Z. A.; Prokof'ev, M. A.

doi:10.1007/bf00568020

Cited by 2 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,4 In the late 1960's ± early 1970's, these scientists performed the synthesis of the first oligo-nucleotide peptides, viz., mixed biopolymers containing oligonucleotide and peptide fragments. 5,6 However, at that time these studies were not extended further, primarily because of the lack of clearcut definitions of molecular-biological tasks which might be solved through the use of peptide ± oligonucleotide conjugates.…”

Section: Introductionmentioning

confidence: 99%

Modern methods for the synthesis of peptide–oligonucleotide conjugates

Zubin¹,

Романова²,

Oretskaya³

2002

Russ. Chem. Rev.

View full text Add to dashboard Cite

The published data on the methods of chemical solution The published data on the methods of chemical solution and solid-phase synthesis of peptide ± oligonucleotide conjugates and solid-phase synthesis of peptide ± oligonucleotide conjugates are reviewed. The known methods are systematised and their are reviewed. The known methods are systematised and their advantages and disadvantages are considered. The approaches to advantages and disadvantages are considered. The approaches to the solution synthesis of peptide ± oligonucleotide conjugates are the solution synthesis of peptide ± oligonucleotide conjugates are systematised according to the type of chemical bonds between the systematised according to the type of chemical bonds between the fragments, whereas those to the solid-phase synthesis are classified fragments, whereas those to the solid-phase synthesis are classified according to the procedure used for the preparation of conjugates, according to the procedure used for the preparation of conjugates, viz viz., stepwise elongation of oligonucleotide and peptide chains on ., stepwise elongation of oligonucleotide and peptide chains on the same polymeric support or solid-phase condensation of two the same polymeric support or solid-phase condensation of two presynthesised fragments. The bibliography includes 141 referen-presynthesised fragments. The bibliography includes 141 references ces. .

show abstract

Section: Introductionmentioning

confidence: 99%