Influence of a Serotonin- and Dopamine-Rich Diet on Platelet Serotonin Content and Urinary Excretion of Biogenic Amines and Their Metabolites

Kema, IP; Schellings, Amj; Meiborg, Gert; Hoppenbrouwers, Cjm; Muskiet, Faj

doi:10.1093/clinchem/38.9.1730

Cited by 75 publications

(49 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In general, sulfation is an inactivating mechanism and a means of detoxification of certain substances (48). Thus, sulfation of DA may be thought of as part of a gut-blood barrier by detoxifying catecholamines that enter the gastrointestinal lumen after ingestion of catecholamine-rich food products (e.g., fruits, tomatoes, nuts, potatoes, and beans) as well as endogenously produced DA (49). Theoretically, this system also functions as a buffering system, reversibly deactivating DA to DA-3-O-sulfate if DA concentrations are too high, and converting DA-3-O-sulfate back to DA if needed.…”

Section: Dopamine Metabolismmentioning

confidence: 99%

Emerging role of dopamine in neovascularization of pheochromocytoma and paraganglioma

et al. 2017

View full text Add to dashboard Cite

Dopamine is a catecholamine that acts both as a neurotransmitter and as a hormone, exerting its functions dopamine (DA) receptors that are present in a broad variety of organs andcells throughout the body. In the circulation, DA is primarily stored in and transported by blood platelets. Recently, the important contribution of DA in the regulation of angiogenesis has been recognized. and studies have shown that DA inhibits angiogenesis through activation of the DA receptor type 2. Overproduction of catecholamines is the biochemical hallmark of pheochromocytoma (PCC) and paraganglioma (PGL). The increased production of DA has been shown to be an independent predictor of malignancy in these tumors. The precise relationship underlying the association between DA production and PCC and PGL behavior needs further clarification. Herein, we review the biochemical and physiologic aspects of DA with a focus on its relations with VEGF and hypoxia inducible factor related angiogenesis pathways, with special emphasis on DA producing PCC and PGL.-Osinga, T. E., Links, T. P., Dullaart, R. P. F., Pacak, K., van der Horst-Schrivers, A. N. A., Kerstens, M. N., Kema, I. P. Emerging role of dopamine in neovascularization of pheochromocytoma and paraganglioma.

show abstract

Section: Dopamine Metabolismmentioning

confidence: 99%

Emerging role of dopamine in neovascularization of pheochromocytoma and paraganglioma

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A kinetic spectrophotometric assay was used to determine serum creatine kinase (CK) activity as described by (Szasz et al, 1976). The quantitative determination of plasma adrenaline and serum serotonin were determined using the enzyme immunoassay as described by Endo et al (2000) and Kema et al (1992), respectively. Quantitative measurements of serum total 3,5,3′triiodothyronine (T3) and L-thyroxine (T4) were carried out using the ELISA procedure as described by Tietz (1987) and Robbins (1971), respectively.…”

Section: Experimental Designmentioning

confidence: 99%

Protective role ofPanax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats

et al. 2006

View full text Add to dashboard Cite

Acrylamide (ACR) is an industrial neurotoxic chemical that has been recently found in carbohydrate-rich foods cooked at high temperatures. ACR was designated as a probable human carcinogen by IARC (1994) and USEPA (1988). Panax ginseng extract has efficacies such as anticancer, antihypertension, antidiabetes and antinociception. The objective of the current study is to evaluate the protective effects of Panax ginseng extract against ACR-induced toxicity in rats. Sixty adult Sprague Dawley female rats were divided into six groups included a control group, a group treated orally with ACR (50 mg kg(-1) body weight; b.w.) for 11 days, a group treated orally with Panax ginseng extract (20 mg kg(-1) b.w.) for 11 days and groups treated orally with Panax ginseng for 11 days before, during or after 11 days of ACR treatment. The results indicated that treatment with ACR alone resulted in a significant increase in lipid peroxidation level and LDH activity in brain homogenate as well as in serum CK activity, whereas it caused a significant decrease in SOD activity and a small but statistically insignificant decrease in Na(+)K(+)-ATPase activity in brain homogenate. Serum serotonin, corticosterone, T3, T4, TSH, estradiol, progesterone and plasma adrenaline were significantly decreased in ACR-treated rats. Treatment with Panax ginseng before, during or after ACR treatment reduced or partially antagonized the effects induced by ACR towards the normal values of controls. It could be concluded that Panax ginseng extract exhibited a protective action against ACR toxicity and it is worth noting that treatment with Panax ginseng extract before or at the same time as ACR treatment was more effective than when administered after ACR treatment.

show abstract

“…False positive 24-hour urine 5-HIAA results may be induced by the ingestion of tryptophan/serotonin-rich foods (pineapple, banana, kiwi, plum, tomato, avocado, walnut, eggplant, hickory nut, etc. ), and certain medications and supplements such as acetaminophen, nicotine, and caffeine (5,6). It is important that these substances be avoided for 24 to 72 hours prior to the 24-hour urine DOI:10.4158/EP15794.CR © 2015 AACE collection.…”

Section: Discussionmentioning

confidence: 99%

The 24-Hour Urinary 5-Hiaa: A Simple Test With a Common Pitfall

Burks¹,

Bao²

2015

AACE Clinical Case Reports

View full text Add to dashboard Cite

Objective: 5-hydroxyindoleaceticacid (5-HIAA) is the principal metabolite of serotonin and the quantitative urinary excretion of 5-HIAA is the most useful way to diagnose serotonin overproduction by carcinoid tumors. The test carries a high specificity, however, many serotonin-rich foods such as pineapple, banana, kiwi, and walnuts will also increase urinary 5-HIAA excretion. We present a case which demonstrates that consumption of these foods prior to the 24 hour collection will falsely elevate the test results. Methods: Case report with literature review. Results: A 39 year old female presented to endocrine clinic with episodes of hot "flushing." She had no diarrhea, diaphoresis, skin rash, muscle weakness, or purple striae. Her primary doctor was concerned for carcinoid syndrome after a 24 hour urine 5-HIAA level was elevated to 22.7 mg/24 hours (normal <6 mg/ 24hours). After negative CT and octreotide scans, it was felt that the patient's 24 hour urine 5-HIAA test was falsely elevated due to dietary intake. She was instructed to avoid serotonin-rich foods prior to her repeat urine collection. The subsequent 24 hour urine test returned within normal limits. She indeed did not have carcinoid syndrome. The patient continued to have "flushing" episodes of feeling short winded and tremulous which resolved with treatment for anxiety. Conclusion: To prevent false positive results and avoid unnecessary testing and imaging, serotonin-rich foods should be avoided for at least 12 hours prior to urine collection. Biochemical tests for diagnosis of clinical syndromes should be interpreted with understanding of the potential for false positive results.

show abstract

Influence of a Serotonin- and Dopamine-Rich Diet on Platelet Serotonin Content and Urinary Excretion of Biogenic Amines and Their Metabolites

Cited by 75 publications

References 0 publications

Emerging role of dopamine in neovascularization of pheochromocytoma and paraganglioma

Emerging role of dopamine in neovascularization of pheochromocytoma and paraganglioma

Protective role ofPanax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats

The 24-Hour Urinary 5-Hiaa: A Simple Test With a Common Pitfall

Contact Info

Product

Resources

About