“…Cortisone is known to counteract the release of pituitary ACTH by the " feed-back" mechanism. Moreover, the role of cortisone in the reduction of urinary excretion of vitam in C and increase in plasm a ascorbic acid level (Booker et al [1951]), de pression of high 17-ketosteroid level of the urine in congenital hyper plasia of adrenal glands (Gardner [1953], Migeon et al [1952], Nowakowski [1952]) has been discussed previously. Moore [1953] has pointed out th a t cortisone alone does not exert any sex horm one or gonadotrophic activity.…”