Influence of aerobic exercise on maternal lipid levels and offspring morphometrics

Clark, Erin A.S.; Isler, Christy; Strickland, Diana; McMillan, Amy Gross; Fang, Xiangming; Kuehn, Devon; Ravisankar, Srikanth; Strom, Cody; May, Linda E.

doi:10.1038/s41366-018-0258-z

Cited by 26 publications

(44 citation statements)

References 54 publications

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“…The neonatal outcomes investigated in the present systematic review included weight, height, head circumference, changes in Apgar score and umbilical cord pH. The meta‐analysis results showed that neonatal weight, height, head circumference, first and fifth‐minute Apgar scores and umbilical cord pH were similar in women who exercised regularly and controls, while the study conducted by Clark et al produced totally different results and demonstrated that exercise can affect neonatal weight, height and head and abdomen circumference (Clark et al., 2019 ). Also, similar to our results regarding neonatal weight, the results of a systematic review and meta‐analysis showed that no significant difference observed in birthweight for infants of mothers who had vigorous intensity exercise in the third trimester of pregnancy compared to mothers who lacked this exposure (Beetham et al., 2019 ).…”

Section: Discussionmentioning

confidence: 94%

Effect of prenatal aerobic exercises on maternal and neonatal outcomes: A systematic review and meta‐analysis

Veisy

Mohammad‐Alizadeh‐Charandabi

Hematzadeh

et al. 2021

Nursing Open

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Pregnancy is among the most sensitive and important stages in the life of parents, and childbirth is an important event in a woman's life. The duration of labour varies in different women and is affected by factors such as age, parity, foetal size and maternal weight (Chen et al., 2018).A prolonged first stage of labour entails complications such as compressed foetal head in the birth canal, lower neonatal Apgar score and foetal death (Allen et al., 2007). A prolonged second stage of labour is associated with increased frequency of caesarean section, tearing of the birth canal and damage to the perineal muscles (Brown et al., 2011). Moreover, a prolonged delivery is also associated with many other maternal complications such as uterine atony and increased maternal mortality, and foetal complications such as foetal distress and reduced foetal Apgar score (Direkvand-Moghadam & Rezaeian, 2012). Given that maternal and neonatal complications increase with the duration

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Section: Discussionmentioning

confidence: 94%

Effect of prenatal aerobic exercises on maternal and neonatal outcomes: A systematic review and meta‐analysis

Veisy

Mohammad‐Alizadeh‐Charandabi

Hematzadeh

et al. 2021

Nursing Open

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“…Over the past two decades, accumulating evidence demonstrates many maternal, fetal and neonatal benefits consequent to participation in recommended levels of exercise during pregnancy [5]. Women engaging in at least the recommended American College of Obstetricians and Gynecologists (ACOG) guidelines [6] (> 150 min per week or 500 MET•min•week − 1 ), experience healthy weight gain [7] and decreased risks of metabolic complications (e.g., gestational diabetes mellitus) [8,9]. Moreover, neonates exposed to exercise in utero exhibit lower percent body fat [10], increased cardiovascular function [11,12], and enhanced neuromotor skills [13].…”

Section: Introductionmentioning

confidence: 99%

The influence of exercise during pregnancy on racial/ethnic health disparities and birth outcomes

Raper

McDonald

Johnston³

et al. 2021

BMC Pregnancy Childbirth

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Background Non-Hispanic black (NHB) pregnant women disproportionately experience adverse birth outcomes compared to Non-Hispanic white (NHW) pregnant women. The positive effects of prenatal exercise on maternal and neonatal health may mitigate these disparities. This study evaluated the influence of prenatal exercise on racial/ethnic disparities in gestational age (GA), birthweight (BW), and risks of preterm birth (PTB), cesarean section (CS), and low-birthweight (LBW) neonates. Methods This study performed a secondary data analysis using data from a 24-week, two-arm exercise intervention trial (ENHANCED by Mom). Women with singleton pregnancies (< 16 weeks), aged 18–40 years, BMI between 18.5–34.99 kg/m2, and no preexisting health conditions were eligible. The aerobic exercisers (EX) participated in 150 min of moderate-intensity weekly exercise while non-exercising controls (CON) attended low-intensity stretching/breathing sessions. Data on GA, PTB (< 37 weeks), BW, LBW (< 2.5 kg), and delivery mode were collected. Poisson, median and linear regressions were performed. Results Participants with complete data (n = 125) were eligible for analyses (EX: n = 58, CON: n = 67). NHB pregnant women delivered lighter neonates (β = − 0.43 kg, 95% CI: − 0.68, − 0.18, p = 0.001). After adjusting for prenatal exercise, racial/ethnic disparities in BW were reduced (β = − 0.39 kg, 95% CI: − 0.65, − 0.13, p = 0.004). Prenatal exercise reduced borderline significant racial/ethnic disparities in PTB (p = 0.053) and GA (p = 0.07) with no effects found for CS and LBW. Conclusions The findings of this study demonstrate that prenatal exercise may attenuate the racial/ethnic disparities observed in neonatal BW, and possibly GA and PTB. Larger, diverse samples and inclusion of maternal biomarkers (e.g., cytokines) are encouraged to further evaluate these relationships.

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“…Interestingly, that study observed these effects earlier in gestation (28–32 weeks), however, these lipids were not assessed in late pregnancy, as done in the current study. Similar to Ramírez‐Vélez et al (2017), Clark et al (2019) showed, when examining prenatal aerobic exercise and neonatal morphometrics, that exercise significantly reduced maternal TG levels in late pregnancy (Clark et al, 2019). The findings of that study, however, were based on nonfasted samples, potentially misestimating the exercise‐induced between‐group differences in maternal lipids.…”

Section: Discussionmentioning

confidence: 72%

The effects of aerobic exercise on markers of maternal metabolism during pregnancy

McDonald

Strom²,

Remchak³

et al. 2020

Birth Defects Research

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Background Optimal maternal metabolism during pregnancy is essential for healthy fetal growth and development. Chronic exercise is shown to positively affect metabolism, predominantly demonstrated in nonpregnant populations. Objective To determine the effects of aerobic exercise on maternal metabolic biomarkers during pregnancy, with expected lower levels of glucose, insulin, and lipids among exercise‐trained pregnant women. Methods Secondary data analyses were performed using data from two, longitudinal prenatal exercise intervention studies (ENHANCED by MOM and GESTAFIT). Exercisers completed 150 min of weekly moderate‐intensity exercise during pregnancy (24+ weeks) while nonexercisers attended stretching sessions. Pregnant women were 31–33 years of age, predominantly non‐Hispanic white, and “normal weight” body mass index. At 16 and 36 weeks of gestation, fasting blood samples were collected via fingerstick and venipuncture. Maternal glucose, insulin, insulin resistance (HOMA‐IR), total cholesterol (TC), low‐density lipoproteins (LDL), high‐density lipoproteins (HDL), and triglycerides (TG) were analyzed. ANCOVA analyses were performed to evaluate the effects of aerobic exercise on markers of maternal metabolism in late pregnancy, controlling for baseline levels. Results Our sample included 12 aerobic exercisers and 54 nonexercising control groups. Significant between‐groups differences at 16 weeks of gestation were found for TG (92.3 vs. 121.2 mg/dl, p = .04), TC (186.8 vs. 219.6 mg/dl, p = .002), and LDL (104.1 vs. 128.8 mg/dl, p = .002). Aerobic‐trained pregnant women exhibited lower insulin levels in late pregnancy (β = −2.6 μIU/ml, 95% CI:−4.2, −0.95, p = .002) and a reduced increase in insulin levels from 16 to 36 week of gestation (β = −2.3 μIU/ml, 95% CI: −4.4, −0.2, p = .034) compared with nonexercising pregnant women. No statistically significant effects were observed for maternal HOMA‐IR, TC, LDL, HDL, TC:HDL, and TG in late pregnancy. Conclusions The observations of this study demonstrate that prenatal exercise may positively affect maternal insulin, with aerobic‐trained pregnant women exhibiting lower insulin levels in late pregnancy. Additionally, we found no appreciable effects of prenatal exercise on maternal lipids in late pregnancy.

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Influence of aerobic exercise on maternal lipid levels and offspring morphometrics

Cited by 26 publications

References 54 publications

Effect of prenatal aerobic exercises on maternal and neonatal outcomes: A systematic review and meta‐analysis

Effect of prenatal aerobic exercises on maternal and neonatal outcomes: A systematic review and meta‐analysis

The influence of exercise during pregnancy on racial/ethnic health disparities and birth outcomes

The effects of aerobic exercise on markers of maternal metabolism during pregnancy

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