Influence of age on the production of Fos and Jun by influenza virus-exposed T cells

Salkind, Alan R.

doi:10.1002/jlb.56.6.817

Cited by 15 publications

(5 citation statements)

References 15 publications

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“…Two studies utilized purified T cells to evaluate age-related changes in IFNyproduction. One study evaluated T-cell production in response to stimulation with live influenza virus and showed a 2-fold, but non-significant decrease, in the number of IFNy producing T-cells when stimulated with live influenza virus as measured by immunofluorescent intracellular cytokine staining [42]. These results are consistent with the two studies of influenza stimulation of PBMC in which both studies showed a decrease, but only one was significant.…”

Section: Ifn7supporting

confidence: 83%

Effect of age on cytokine production in humans

Bernstein

Murasko

1998

AGE

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Aging is accompanied by many changes in immune response, with the most consistent and dramatic alterations occurring within the T cell compartment. Since cytokines are central to immune cell communications, age-associated changes in cytokine production may contribute to these alterations. While data from murine studies suggest a switch from a Th1 (IL-2, IFNγ) to a Th2 (IL-4, IL-6, IL-10) cytokine response, this model has not been as clearly established in humans. In addition, this current review of over 50 studies in humans suggests that age-associated changes in cytokine production are not consistent.

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Section: Ifn7supporting

confidence: 83%

Effect of age on cytokine production in humans

Bernstein

Murasko

1998

AGE

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“…92demonstrating decreased cjun mRNA but normal c-fos mRNA responses to PHA in T cells from elderly donors. Moreover, fewer lymphocytes from elderly donors exposed to influenza virus in vitro expressed fos and jun compared to cells of younger donors, possibly as a reflection of compromized activation of antiviral responses (105). Amongst the transcription factors of known importance for IL 2 production, CD3-stimulated induction of NF-kappa B was also found to be decreased in old mice (106) and humans (107).…”

Section: Alterations In Signal Transductionmentioning

confidence: 99%

T cells and aging

Pawelec

Remarque²,

Barnett³

et al. 1998

Front Biosci

131

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Deterioration of the immune system with aging ("immunosenescence") is believed to contribute to morbidity and mortality in man due to the greater incidence of infection, as well as possibly autoimmune phenomena and cancer in the aged. Dysregulation of T cell function is thought to play a critical part in these processes. Factors contributing to T cell immunosenescence may include a) stem cell defects, b) thymus involution, c) defects in antigen presenting cells (APC), d) aging of resting immune cells, e) disrupted activation pathways in immune cells, f) replicative senescence of clonally expanding cells. This review aims to consider the current state of knowledge on the scientific basis for and potential clinical relevance of those factors in immunosenescence.

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“…These data are consistent with those of Song et al (177) demonstrating decreased c-jun mRNA but normal c-fos mRNA responses to PHA in T cells from elderly donors. Moreover, fewer lymphocytes from elderly donors exposed to influenza virus in vitro expressed fos and jun compared to cells of younger donors, possibly as a reflection of compromised activation of anti-viral responses (188). In Fischer rats, the age-associated decrease in IL 2 mRNA and protein correlates with a decreasing ability of nuclear extracts of freshly isolated T cells to bind an oligonucleotide representing the transcription factor NF-AT (189), suggesting differences in transcriptional regulation in young and old cells.…”

Section: Cytokine Production and Responsementioning

confidence: 99%

T cells and aging (update February 1999)

Pawelec

1999

Front Biosci

113

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T cell immunosenescence 218effects of dysregulated immune responses in the elderly by supplementation or other approaches may result in an enhancement of their quality of life, and significant reductions in the cost of medical care in old age. FACTORS CONTRIBUTING TO IMMUNO-SENESCENCE HematopoiesisDysregulated hematopoiesis is seen in elderly individuals, raising the possibility that this could contribute to altered immune function in the aged. Hematopoiesis in man may be compromised because of a severely reduced capacity to produce colony stimulating factors (44) and increased production of pro-inflammatory factors such as IL 6 (45), because lower numbers of progenitor cells are present in the BM (46) and because of an age-related decline in proliferative potential of putative haematopoietic stem cells (HSC) (47). In mice, the repopulating potential of murine fetal liver-derived HSC is higher than that of adult BM-derived stem cells (48), suggesting possible aging of the HSC themselves. Normal cells with shorter telomeres possess less remaining replicative capacity than those with longer telomeres (see section 5.2). Accordingly, HSC from adult BM were found to have shorter telomeres than fetal liver-derived or umbilical cord-derived stem cells, consistent with aging of HSC (49). Telomere lengths decreased on culture despite low level expression of telomerase in these cells (50,51), although the rate of basepair loss per population doubling of cells in culture was lower during the first two weeks, when telomerase was upregulated, than in the next two, when it was downregulated (52). The telomerase expressed is therefore functionally active but may not be able to completely maintain telomere length in aging HSC cells. True embryonic stem cells (ESC), on the other hand, which may really be immortal, do retain high levels of telomerase activity (53). On the other hand, ESC from telomerase-knockout mice show gradual telomere shortening over many population doublings (PD) resulting in slowing and eventual cessation of growth (54). Certain animals which do not downregulate telomerase manifest a permanent growth phase and little or no senescence (55,56).

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Influence of age on the production of Fos and Jun by influenza virus-exposed T cells

Cited by 15 publications

References 15 publications

Effect of age on cytokine production in humans

Effect of age on cytokine production in humans

T cells and aging

T cells and aging (update February 1999)

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