Nickel-base superalloys such as Rene´80 are widely used in manufacturing aircraft turbine blades. They are usually coated in order to increase their wear, oxidation, erosion, and hot corrosion properties against environmental degradation. In this article, the mechanical behavior (tensile and low-cycle fatigue (LCF)) of uncoated and aluminide-coated (CODEP-B) Rene8 0 has been studied at 871°C and 982°C. Experimental results show that the tensile properties of coated specimens are relatively lower than those of uncoated ones in the same conditions, but application of coating increases the LCF life of Rene´80 at T = 871°C, 982°C, R = (e min /e max ) = 0, strain rate of 2 9 10 À3 s À1 , and De t = 0.8 pct. Scanning electron microscopy (SEM) studies of coated specimens at N = Nf show that the nucleation of cracks occurs merely in substrate, but cracks start from the surfaces in uncoated specimens. Transmission electron microscopy (TEM) investigations have been performed on fractured uncoated specimens to evaluate the microstructures at different temperatures. The misfit dislocation, pair dislocations, and cutting of c¢ were observed at T = 871°C and 982°C. The TEM studies also showed that at 982°C stacking fault was observed in c¢ particles.