Influence of an optimized non-ionic emulsifier blend on properties of oil-in-water emulsions

Design and optimization of a new self-nanoemulsifying drug delivery system

“…Sagitani [21] suggested that a proper surfactant HLB value was a key factor for the formation of emulsion with small droplets. The HLB system predicts the best emulsifier is obtained when the HLB values of the emulsifier and oil are matched [22]. Spans and Tweens are well-known non-ionic sorbitan alkanoates and ethoxylated sorbitan alkanoates, with a wide range of HLB values which are appropriate for tuning the HLB [23].…”

Design and investigation of nanoemulsified carrier based on amphiphile-modified hyaluronic acid

“…Certain mixtures of surfactants can provide better performance than use of a single surfactant (Rosen, 1992;Scamehorn, 1986). In a mixed non-ionic surfactant system, HLB has been proven to be very useful in attaining the best type of emulsifier for any given oil phase (Gullapalli & Sheth, 1999;Wang et al, 2009); the best type of emulsifier is designated the required HLB. For O/W emulsions, surfactants with higher HLB tend to stabilize the system, thus, HLB values ranging from 8 to 15 were presently chosen, from which the required HLB was obtained.…”

Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design

“…In such a system, the hydrophilic emulsifiers were thought to align alongside each other, imparting more rigidity and strength to the emulsifier film through hydrogen bonding. 29 In addition, with regard to particle distribution, the polydispersity index is an indicator of the homogeneity of the size distribution. The PI value of 0.277 indicated that the optimal composition could be used to produce a stable SLN dispersion with a relatively narrow size distribution for chloramphenicol-loaded SNL.…”