Influence of anti‐inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies

Kałuża, Joanna; Håkansson, Niclas; Harris, Holly R.; Orsini, Nicola; Michaëlsson, Karl; Wolk, Alicja

doi:10.1111/joim.12823

Cited by 28 publications

(38 citation statements)

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“…Obesity, type 2 diabetes, and other metabolic disorders have a large impact on the health of society in Western and developing countries. These disorders not only increase the risk of cardiovascular disease; they also represent a common preventable cause of cancer (1, 2). Currently, about 15% of the world population suffers from obesity, 5–10% has type 2 diabetes, and these numbers are increasing (3, 4).…”

Section: Introductionmentioning

confidence: 99%

Current and Future Nutritional Strategies to Modulate Inflammatory Dynamics in Metabolic Disorders

et al. 2019

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Obesity, type 2 diabetes, and other metabolic disorders have a large impact on global health, especially in Western countries. An important hallmark of metabolic disorders is chronic low-grade inflammation. A key player in chronic low-grade inflammation is dysmetabolism, which is defined as the inability to keep homeostasis resulting in loss of lipid control, oxidative stress, inflammation, and insulin resistance. Although often not yet detectable in the circulation, chronic low-grade inflammation can be present in one or multiple organs. The response to a metabolic challenge containing lipids may magnify dysfunctionalities at the tissue level, causing an overflow of inflammatory markers into the circulation and hence allow detection of early low-grade inflammation. Here, we summarize the evidence of successful application of metabolic challenge tests in type 2 diabetes, metabolic syndrome, obesity, and unhealthy aging. We also review how metabolic challenge tests have been successfully applied to evaluate nutritional intervention effects, including an “anti-inflammatory” mixture, dark chocolate, whole grain wheat and overfeeding. Additionally, we elaborate on future strategies to (re)gain inflammatory flexibility. Through epigenetic and metabolic regulation, the inflammatory response may be trained by regular mild and metabolic triggers, which can be understood from the perspective of trained immunity, hormesis and pro-resolution. New strategies to optimize dynamics of inflammation may become available.

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Section: Introductionmentioning

confidence: 99%

Current and Future Nutritional Strategies to Modulate Inflammatory Dynamics in Metabolic Disorders

et al. 2019

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“…We observed that the average hsCRP among people with low AIDI was 1.0 mg/L as compared with 1.8 mg/L among those with high AIDI 15. Adherence to a diet with a high AIDI score was inversely associated with cardiovascular (CVD) mortality and was associated with increased survival time in a population-based prospective cohort of Swedish men and women 16. Until now, the anti-inflammatory potential of diet has not been examined in relation to specific types of CVD, including AAA.…”

Section: Introductionmentioning

confidence: 90%

Anti-inflammatory diet and risk of abdominal aortic aneurysm in two Swedish cohorts

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et al. 2019

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ObjectiveThe relationship between dietary patterns and development of abdominal aortic aneurysm (AAA) is not well understood. Thus, we prospectively evaluated the association between the anti-inflammatory potential of diet and risk of AAA.MethodsThe study population included the Cohort of Swedish Men (45 072 men) and the Swedish Mammography Cohort (36 633 women), aged 45–83 years at baseline. The anti-inflammatory potential of diet was estimated using Anti-inflammatory Diet Index (AIDI) based on 11 foods with anti-inflammatory potential and 5 with proinflammatory potential (maximum 16 points) that was validated againsthigh sensitivity C reactive protein (hsCRP). Cox proportional hazard regression models were used to estimate HRs and 95% CIs. During the 14.9 years of follow-up (1 217 263 person-years), 1528 AAA cases (277 (18%) ruptured, 1251 non-ruptured) were ascertained via the Swedish Inpatient Register, the National Cause of Death Register and the Register for Vascular Surgery (Swedvasc).ResultsWe observed an inverse association between the AIDI and AAA risk in women and men; HRs between extreme quartiles of the AIDI (≥8 vs ≤5 points) were 0.55 (95% CI 0.36 to 0.83) in women and 0.81 (95% CI 0.68 to 0.98) in men. The AIDI was inversely associated with both ruptured and non-ruptured AAA incidence; the HR of participants in the highest quartile of AIDI compared with those in the lowest quartile was 0.61 (95% CI 0.41 to 0.90) for ruptured AAA and 0.79 (95% CI 0.65 to 0.95) for non-ruptured AAA.ConclusionAdherence to diet with a high anti-inflammatory potential was associated with a reduced AAA risk, an association that was even more pronounced for AAA rupture.

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“…Following stratification by sex, the association between the anti-inflammatory diet index and cancer mortality was significant only amongst men. In addition, the observed associations were strongest amongst current smokers [1]. This manuscript indubitably provides important and striking informations, and we would like to take this opportunity to share some additional thoughts and to partake our considerations.…”

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confidence: 90%

“…Dear Sir, In their very significant and well-presented large, population-based prospective cohort study entitled 'Influence of anti-inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies' recently published in the Journal of Internal Medicine [1], Kaluza et al examined the associations between an anti-inflammatory diet index and all-cause and cause-specific mortality, determined the association between the anti-inflammatory diet index and differences in survival time and assessed effect modification by smoking status. [1]. The results showed that adherence to a diet with high anti-inflammatory potential was associated with increased survival time and lower all-cause, cardiovascular disease and cancer mortality.…”

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confidence: 99%

Anti‐inflammatory diet to reduce mortality: is it time for a precision medicine approach?

et al. 2018

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Influence of anti‐inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies

Abstract: Adherence to a diet with high anti-inflammatory potential may reduce all-cause, CVD and cancer mortality and prolong survival time especially amongst smokers.

Cited by 28 publications

References 63 publications

Current and Future Nutritional Strategies to Modulate Inflammatory Dynamics in Metabolic Disorders

Current and Future Nutritional Strategies to Modulate Inflammatory Dynamics in Metabolic Disorders

Anti-inflammatory diet and risk of abdominal aortic aneurysm in two Swedish cohorts

Anti‐inflammatory diet to reduce mortality: is it time for a precision medicine approach?

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