Influence of block copolymers on the adsorption of plasma proteins to microspheres

A surface plasmon resonance study of albumin adsorption to PEO-PPO-PEO triblock copolymers

“…They claimed that a PPO chain length of 39 units was required to inhibit adsorption. Norman et al (1993) 11 used SDS-PAGE to investigate protein adsorption from plasma to Pluronic-coated surfaces and showed similar adsorption of protein to Pluronics F85 and F88, both with the same PPO block chain length but with differing PEO chain length. When comparing these with protein adsorption to Pluronic F127, where the PPO block size has increased but the PEO chain length is the same as F68, there was a marked decrease in protein adsorption.…”

“…Protein adsorption to Pluronic coatings has been in-vestigated by a number of groups using techniques such as reflectometry, 10 SDS-Page Gels, 11 and radiolabeling, 12 and each has observed a reduction of protein adsorption. Amiji and Park (1992) 12 demonstrated that a Pluronic layer can reduce both fibrinogen adsorption and platelet adhesion, and they suggested that the PPO block size is the major factor for the prevention of platelet adhesion.…”

Cationic Polystyrene Nanoparticles: Preparation and Characterization of a Model Drug Carrier System for Antisense Oligonucleotides

“…These interactions were shown to be reduced by steri-ODN-S. Furthermore, incubating the latexes with cell culture cally stabilized nanoparticles bearing a more hydrophilic sur-medium or medium plus oligonucleotide (3 mmol/L) leads face than unmodified polystyrene latexes (30). The low in-to a high extent of coagulation in case of the uncoated mateflammatory response induced by poloxamer-coated polysty-rial, in contrast to the sterically stabilized latexes where no rene nanoparticles in comparison to uncoated material also coagulation could be detected (data not shown).…”

PEG–PLGA based large porous particles for pulmonary delivery of a highly soluble drug, low molecular weight heparin

“…One of the major advantages of PEG-PLGA particles over PLGA is that because of the presence of hydrophilic PEG chains, the former can evade recognition by the cells of the reticuloendothelial system [11,12]. Hence, PEG-PLGA block polymers have been used to prepare polymeric micelles, nanoparticles and polymer-drug conjugates to extend the circulation life and accomplish passive targeting of many drugs including anti-cancer and anti-microbial drugs [13][14][15].Whilethesepolymershavebeenusedextensivelytoprepare micellebasednanoparticles,therearelittleornoreportswithregardtotheir use in preparation of microparticles by the double-emulsion-solventevaporationmethod.Thiswasperhapsbecauseofexcessivehydrophilicity of PEG-PLGA that imposes limitation with regard to the amount of drugs that can be entrapped in those particles.…”