Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with rheumatoid arthritis

Lindqvist, Helen M.; Gjertsson, Inger; Andersson, S.; Calder, Philip C.; Bärebring, Linnea

doi:10.1016/j.plefa.2019.08.004

Cited by 12 publications

(7 citation statements)

References 34 publications

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“…Another study in an RA Swedish population found that EPA and DHA were both increased in erythrocytes after a blue mussel diet compared to a control diet, resulting in a decrease of n-6 PUFA ARA (20:4 n-6) and dihomo-gamma-linolenic acid (DGLA; 20:3 n−6), as well as a small decrease in saturated fatty acids and the monounsaturated fatty acid palmitoleic acid (16:1 n-7). Baseline EPA and DHA levels in this population were higher than in healthy men and women, but this group had of 31 already reported that the RA population from the studied area had a higher fish and shellfish intake compared to the general population of Sweden [211]. In contrast to these findings, erythrocyte levels of α-linolenic acid (ALA; 18:3n3), EPA 20:5n3, and the omega-3 index (EPA plus DHA) were found to be significantly lower in RA patients compared to healthy controls in a Korean population, although diet was not accounted for in this study.…”

Section: Studies Of Beneficial Effect Of Diet In Ramentioning

confidence: 57%

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

Coras

Murillo-Saich

Gumá

2020

Cells

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Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved the treatment of RA, patients often inquire about dietary interventions to improve RA symptoms, as they perceive pain and/or swelling after the consumption or avoidance of certain foods. There is evidence that some foods have pro- or anti-inflammatory effects mediated by diet-related metabolites. In addition, recent literature has shown a link between diet-related metabolites and microbiome changes, since the gut microbiome is involved in the metabolism of some dietary ingredients. But diet and the gut microbiome are not the only factors linked to circulating pro- and anti-inflammatory metabolites. Other factors including smoking, associated comorbidities, and therapeutic drugs might also modify the circulating metabolomic profile and play a role in RA pathogenesis. This article summarizes what is known about circulating pro- and anti-inflammatory metabolites in RA. It also emphasizes factors that might be involved in their circulating concentrations and diet-related metabolites with a beneficial effect in RA.

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Section: Studies Of Beneficial Effect Of Diet In Ramentioning

confidence: 57%

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

Coras

Murillo-Saich

Gumá

2020

Cells

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“…We have previously presented findings showing that patterns of erythrocyte fatty acids could predict all individuals’ dietary periods (mussel intervention vs. control diet) correctly in an OPLS-EP model [ 21 ], but this was not possible for oxylipins. Neither OPLS-EP nor OPLS-DA resulted in models of high quality with a good predictability ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Fasting blood samples were collected before and after each dietary period and were analyzed for free fatty acids and oxylipins in erythrocytes. Erythrocyte fatty acid concentrations have been reported previously [ 21 ]. Figure 3 describes the relationship between the presented lipids (total fatty acids, free fatty acids, and oxylipins) in erythrocytes in this paper and their products.…”

Section: Methodsmentioning

confidence: 99%

“…Intervention diets rich in EPA and DHA increased these fatty acids in both studies, and the fatty acid pattern changed significantly in erythrocytes and plasma. Despite this, the effects on inflammation markers were limited [ 21 , 22 ]. Because changes in pro and anti-inflammatory lipid mediators, such as oxylipins, precede changes in other inflammatory markers such as cytokines, it would be of value to establish if oxylipins changed in line with changed dietary fatty-acid intake.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis

et al. 2023

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Oxylipins derived from n-3 fatty acids are suggested as the link between these fatty acids and reduced inflammation. The aim of the present study was to explore the effect of a randomized controlled cross-over intervention on oxylipin patterns in erythrocytes. Twenty-three women with rheumatoid arthritis completed 2 × 11-weeks exchanging one cooked meal per day, 5 days a week, for a meal including 75 g blue mussels (source for n-3 fatty acids) or 75 g meat. Erythrocyte oxylipins were quantified by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The results were analyzed with multivariate data analysis. Orthogonal projections to latent structures (OPLS) with effect projections and with discriminant analysis were performed to compare the two diets’ effects on oxylipins. Wilcoxon signed rank test was used to test pre and post values for each dietary period as well as post blue-mussel vs. post meat. The blue-mussel diet led to significant changes in a few oxylipins from the precursor fatty acids arachidonic acid and dihomo-ɣ-linolenic acid. Despite significant changes in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and free EPA in erythrocytes in the mussel group, no concurrent changes in their oxylipins were seen. Further research is needed to study the link between n-3 fatty-acid intake, blood oxylipins, and inflammation.

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“…In a study by Lindqvist [ 18 ], patients on a blue mussel diet had lower CRP, fewer tender joints, significantly improved global health and reduced pain and fatigue. In another study by Lindqvist [ 17 ], changes in the increase of omega-3 FAs EPA and DHA were observed in a group of patients who consumed blue mussels. In a study by Barebring et al [ 65 ], a diet rich in fish, crustaceans, fruit and vegetables and whole grains was associated with a reduction in ESR (B = −2.4, p = 0.002) and hs-CRP (B = −0.6, p = 0.044).…”

Section: The Role Of Fatty Acids In the Treatment Of Ramentioning

confidence: 99%

The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis

Tański¹,

Świątoniowska-Lonc²,

Tabin³

et al. 2022

Nutrients

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For this systematic review, a search of the relevant literature was conducted in the EMBASE and PubMed databases. We used the following terms: ‘rheumatoid arthritis’ in conjunction with ‘fatty acid’. The following inclusion criteria had to be satisfied for the studies to be included in the analysis: an RCT/observational/cohort study published in English. A total of seventy-one studies were analysed. The presented systematic review of the available data indicates that increased consumption of omega-3 fatty acids (FAs) may have a beneficial effect on human health by decreasing pain and disease activity in patients with RA. The beneficial effect of unsaturated FA on the clinical parameters of RA was demonstrated in all 71 studies analysed. The content of omega-3 FAs in the diet and the consumption of fish, which are their main source, may contribute to a reduced incidence of RA. FAs are an essential component in the synthesis of eicosanoids that exhibit anti-inflammatory properties. Due to the documented positive influence of unsaturated FAs on treatment outcomes, the use of a diet rich in long-chain unsaturated FAs should be the standard of care, along with pharmacotherapy, in the treatment of RA patients. An important element in the control of the treatment process should be the routine assessment of the quality of life of RA patients.

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Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with rheumatoid arthritis

Cited by 12 publications

References 34 publications

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis

The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis

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