Influence of bovine serum albumin on corrosion behaviour of pure Zn in phosphate buffered saline

Abstract

Zinc (Zn) and its alloys have received increasing attention as new alternative biodegradable metals. However, consensus has not been reached on the corrosion behaviour of Zn. As cardiovascular artery stent material, Zn is supposed to contact with plasma that contains inorganic salts and organic components. Protein is one of the most important constitute in the plasma and could adsorb on the material surface. In this paper, bovine serum albumin (BSA) was used as a typical protein. Influences of BSA on pure Zn corrosion in phosphate buffered saline is investigated as a function of BSA concentrations and immersion durations by electrochemical techniques and surface analysis. Results showed that pure Zn corrosion was progressively accelerated with BSA concentrations (ranging from 0.05 to 5 g L−1) at 0.5 h. With time evolves, formation of phosphates as corrosion product was delayed by BSA adsorption, especially at concentration of 2 g L−1. Within 48 h, the corrosion of pure Zn was alleviated by BSA at concentration of 0.1 g L−1, whereas the corrosion was enhanced after 168 h. Addition of 2 g L−1 BSA has opposite influence on the pure Zn corrosion. Furthermore, schematic corrosion behaviour at protein/Zn interfaces was proposed. This work encourages us to think more about the influence of protein on the material corrosion and helps us to better understand the corrosion behaviour of pure Zn.

Corrosion Mechanisms of a Biodegradable Zn-0.4Li Alloy in Simulated Gastrointestinal Environment

“…A low pH value is not conducive to passivation film formation. On the other hand, the corrosion rate can be slowed down by the passivation film that is created by hydrogen phosphate and Zn ions [40,49,53]. Owing to these factors, the corrosion of Zn atoms in the sample proceeded slowly in SIF in the current study.…”

“…Notably, round flower-like corrosion products occupied most of the sample surface after immersion in SIF for 3 days, as shown in Figure 3a. These round flower-like corrosion products were formed because the sample surfaces absorbed abundant PO4 3-in the solution during immersion in SIF [40].…”

Development of Organic/Inorganic Hybrid Materials for Fully Degradable Reactive Oxygen Species-Releasing Stents for Antirestenosis

“…Therefore, the dendritic morphology can be inferred to be the residual corrosion products of the Mg film on top of the continuous corrosion products of the Zn film. As the corrosion products were composed of Mg and Zn originating from the metallic layers and P, O, K, Na, and Cl originating from the immersion solution [1× PBS (pH 7.4) containing NaCl, KCl, Na 2 HPO 4 , and KH 2 PO 4 ], − there would be no toxicity issue resulting from the biodegradation of hybrid materials.…”

Influence of Enzymes on the In Vitro Degradation Behavior of Pure Zn in Simulated Gastric and Intestinal Fluids

“…Corrosion behavior, including corrosion rate and products, is of great importance for understanding the basic corrosion processes of biodegradable metals. To date, multitudinous efforts have been committed to tackling the in vitro corrosion behavior of Zn-based materials in simulated physiological conditions. ,,, Implants are in contact with tissue medium and blood in the body, which contain salts and organic molecules. ,, To understand the role of organic compounds in the regulation of Zn-based alloy degradation, the effects of albumin on the degradation of zinc alloys in simulated body fluid and artificial plasma have been studied. − Nowadays, surgical staples are widely used for healing and reconstruction of the stomach and intestinal tract in gastrointestinal anastomosis. , Zn and its alloys, as new candidates for biodegradable staples, can prevent the long-term complications of traditional nondegradable Ti alloy staples. Guo et al explored the feasibility of Zn alloys as biodegradable staples in gastrointestinal anastomosis through in vitro and in vivo studies .…”

“… 19 , 23 , 24 To understand the role of organic compounds in the regulation of Zn-based alloy degradation, the effects of albumin on the degradation of zinc alloys in simulated body fluid and artificial plasma have been studied. 25 − 31 Nowadays, surgical staples are widely used for healing and reconstruction of the stomach and intestinal tract in gastrointestinal anastomosis. 32 , 33 Zn and its alloys, as new candidates for biodegradable staples, can prevent the long-term complications of traditional nondegradable Ti alloy staples.…”