Influence of Breast Versus Formula Milk on Physiological Gastroesophageal Reflux in Healthy, Newborn Infants

Heacock, Helen; Jeffery, Heather; Baker, Jennifer L.; Page, Megan

doi:10.1097/00005176-199201000-00009

Cited by 85 publications

(55 citation statements)

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“…Two more recent studies found that gastric emptying of non-homogenised fat26 and of solids27 is faster in patients with cystic fibrosis than in normal individuals. Breast fed infants may have lower rates of GOR and more rapid gastric emptying than bottle fed infants 28. Although most infants in our study were breast fed, we did not find a difference in reflux indices compared with the bottle fed infants.…”

Section: Discussioncontrasting

confidence: 69%

Gastro-oesophageal reflux in infants under 6 months with cystic fibrosis

Heine

Button

Olinsky

et al. 1998

Archives of Disease in Childhood

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Aim-To establish the incidence of pathological gastro-oesophageal reflux (GOR) in newly diagnosed infants with cystic fibrosis and to identify clinical predictors of increased reflux. Methods-26 infants with cystic fibrosis less than 6 months of age (14 male, 12 female; mean (SEM) age 2.1 (0.21) months, range 0.8 to 5.6 months) underwent prolonged oesophageal pH monitoring (mean duration 27.1 (0.49) hours; range 21.3 to 30.2 hours). Reflux symptoms, anthropometric variables, pancreatic status, meconium ileus, genotype, and chest x ray findings were correlated with pH monitoring data. Results-Five infants (19.2%) had an abnormal fractional reflux time of greater than 10%, seven (26.9%) of 5-10%, and 14 (53.8%) of below 5%. Infants who presented with frequent vomiting had a significantly higher fractional reflux time than infants who had infrequent or no vomiting. There was no significant association between abnormal chest x rays and pathological GOR. Sex, genotype, nutritional status, meconium ileus, and pancreatic enzyme supplementation were not significantly associated with pathological GOR. Conclusions-About one in five newly diagnosed infants with cystic fibrosis had pathological GOR. Pathologically increased reflux was present before radiological lung disease was established. Apart from frequent vomiting, no useful clinical predictors of pathological reflux were found. (Arch Dis Child 1998;78:44-48)

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Section: Discussioncontrasting

confidence: 69%

Gastro-oesophageal reflux in infants under 6 months with cystic fibrosis

Heine

Button

Olinsky

et al. 1998

Archives of Disease in Childhood

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“…Furthermore, reflux parameters are altered by changes in arousal state, feed type, and posture. [18][19][20][21] The disease status of the patients enrolled in this study was judged firstly on the basis of clinical assessment by a neonatologist and then further examined by reflux symptom charting and 24 hour oesophageal pH monitoring. Confirmation of the clinical diagnosis of GORD using pH monitoring has been used in other studies, 22 one of these 23 indicating that infants selected in this way have increased acid oropharyngeal aspirates which may in itself be useful diagnostically.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease

Omari

Barnett

Benninga

et al. 2002

Gut

232

175

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“…These results are possibly related to more quiet sleep (associated with rare reflux episodes), improved clearance rate, and enhanced gastric emptying, maybe related to differences in macronutrient content such as lipids and other components such as growth factor (not analyzed in this study). 108 When CMA-related GERD is suspected, a dietetic trial with complete avoidance of CMP (with calcium supplementation when required) in the maternal diet is suggested for 3 to 4 weeks. When helpful, CMP should be reintroduced in the maternal diet to prove any causal relationship.…”

Section: Breast Milkmentioning

confidence: 99%

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

Salvatore¹,

Vandenplas

2002

Pediatrics

110

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Gastroesophageal reflux (GER) and cow milk allergy (CMA) occur frequently in infants younger than 1 year. In recent years, the relation between these 2 entities has been investigated and some important conclusions have been reached: in up to half of the cases of GER in infants younger than 1 year, there may be an association with CMA. In a high proportion of cases, GER is not only CMA associated but also CMA induced. The frequency of this association should induce pediatricians to screen for possible concomitant CMA in all infants who have GER and are younger than 1 year. With the exception of some patients with mild typical CMA manifestations (diarrhea, dermatitis, or rhinitis), the symptoms of GER associated with CMA are the same as those observed in primary GER. Immunologic tests and esophageal pH monitoring (with a typical pH pattern characterized by a progressive, slow decrease in esophageal pH between feedings) may be helpful if an association between GER and CMA is suspected, although the clinical response to an elimination diet and challenge is the only clue to the diagnosis. This article reviews the main features of GER and CMA, focusing on the aspects in common and the discrepancies between both conditions.

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Influence of Breast Versus Formula Milk on Physiological Gastroesophageal Reflux in Healthy, Newborn Infants

Cited by 85 publications

References 0 publications

Gastro-oesophageal reflux in infants under 6 months with cystic fibrosis

Gastro-oesophageal reflux in infants under 6 months with cystic fibrosis

Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease

Gastroesophageal Reflux and Cow Milk Allergy: Is There a Link?

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