Influence of Butyrate Loaded Clinoptilolite Dietary Supplementation on Growth Performance, Development of Intestine and Antioxidant Capacity in Broiler Chickens

Wu, Yanan; Zhou, Yanmin; Chen, Lu; Ahmad, Hassan; Zhang, Hao; He, Jun; Zhang, Lili

doi:10.1371/journal.pone.0154410

Cited by 47 publications

(42 citation statements)

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“…A reduction in CD may reduce intestinal maintenance requirement, thereby reserving stores of energy and protein for use in muscle deposition [ 44 ]. These results suggest that the absorption function of broilers in the LE group is superior to the secretion function, which is expected to improve the capacity for digestion and absorption of nutrients from the intestine [ 45 , 46 ]. The early LP exhibited improvement in subsequent intestinal development with higher VH of the intestine, and LE-LP significantly decreased the CD and enhanced the VH:CD ratio.…”

Section: Discussionmentioning

confidence: 99%

Effect of early dietary energy restriction and phosphorus level on subsequent growth performance, intestinal phosphate transport, and AMPK activity in young broilers

Miao

Zhang

et al. 2017

PLoS ONE

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We aimed to determine the effect of low dietary energy on intestinal phosphate transport and the possible underlying mechanism to explain the long-term effects of early dietary energy restriction and non-phytate phosphorus (NPP). A 2 × 3 factorial experiment, consisting of 2 energy levels and 3 NPP levels, was conducted. Broiler growth performance, intestinal morphology in 0–21 days and 22–35 days, type IIb sodium-phosphate co-transporter (NaPi-IIb) mRNA expression, adenylate purine concentrations in the duodenum, and phosphorylated adenosine monophosphate-activated protein kinase (AMPK-α) activity in 0–21 days were determined. The following results were obtained. (1) Low dietary energy (LE) induced a high feed conversion ratio (FCR) and significantly decreased body weight gain in young broilers, but LE induced significantly higher compensatory growth in low NPP (LP) groups than in the high or medium NPP groups (HP and MP). (2) LE decreased the villus height (VH) in the intestine, and LE-HP resulted in the lowest crypt depth (CD) and the highest VH:CD ratio in the initial phase. However, in the later period, the LE-LP group showed an increased VH:CD ratio and decreased CD in the intestine. (3) LE increased ATP synthesis and decreased AMP:ATP ratio in the duodenal mucosa of chickens in 0–21 days, and LP diet increased ATP synthesis and adenylate energy charges but decreased AMP production and AMP:ATP ratio. (4) LE led to weaker AMPK phosphorylation, higher mTOR phosphorylation, and higher NaPi-IIb mRNA expression. Thus, LE and LP in the early growth phase had significant compensatory and interactive effect on later growth and intestinal development in broilers. The effect might be relevant to energy status that LE leads to weaker AMPK phosphorylation, causing a lower inhibitory action toward mTOR phosphorylation. This series of events stimulates NaPi-IIb mRNA expression. Our findings provide a theoretical basis and a new perspective on intestinal phosphate transport regulation, with potential applications in broiler production.

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Section: Discussionmentioning

confidence: 99%

Effect of early dietary energy restriction and phosphorus level on subsequent growth performance, intestinal phosphate transport, and AMPK activity in young broilers

Miao

Zhang

et al. 2017

PLoS ONE

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“…The T-AOC includes the effects of several antioxidant enzymes and related biomolecules with the ability to remove free radicals of a specific organ or a living organism. The level of T-AOC reflects the total antioxidant ability (Wu et al 2016;Attia et al 2017Attia et al , 2018Attia et al , 2019a. In this study, supplemented AAE boosted the T-AOC of serum, liver and spleen to some degree, which might be associated with obvious in vitro antioxidant activity of AAE and increased activity of antioxidant agents and expression of the relevant gene, and decreased levels of lipid peroxidation in vivo.…”

Section: Discussionmentioning

confidence: 55%

“…T-AOC capacity was expressed as lmol trolox equivalent and lmol trolox equivalent per gram protein of homogenates (mM, lmol TE/g protein). All the above kits have been successfully used in poultry study (Wu et al 2016;Wan et al 2016;Song et al 2018).…”

Section: Determination Of Antioxidant Capacities In Serum Liver and mentioning

confidence: 99%

Artemisia annua L. aqueous extract as an alternative to antibiotics improving growth performance and antioxidant function in broilers

Guo

Xing

et al. 2020

Italian Journal of Animal Science

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Due to a series of problems, such as drug resistance and tissue residue caused by adding antibiotics to feed, this research aimed to study the effects of Artemisia annua L. aqueous extract (AAE) as an alternative to antibiotics on growth performance and antioxidant capacity of broilers. A total of 240 one-day-old mixed-sex Arbour Acres broilers were randomly allotted into six groups with five replicates of eight birds each. These six diets were formulated by adding 0, 500, 1000, 1500, 2000 mg/kg AAE and 50 mg/kg chlortetracycline (CTC) to the basal diet, respectively. Average daily body weight gain (ADG), average daily feed intake (ADFI), and feed conversion ratio (FCR) were measured. Total antioxidant capacity (T-AOC), the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and the concentrations of malondialdehyde (MDA) were determined, and the relative gene expression in tissues was measured. The polyphenol flavonoid contents and in vitro antioxidative results showed that: the total phenolic and flavonoid contents were 39.58 ± 6.01 mg GAE/g, 7.04 ± 0.55 mg RE/g, respectively. The inclusion of AAE increased ADG, the activities of T-AOC, CAT, SOD and GSH-Px, and the gene expression of antioxidant enzymes, the concentrations of MDA decreased in serum and tissues. In conclusion, AAE can be used as a feed additive due to its capability to improve growth performance, antioxidant function in broilers. Dietary inclusion of 1000-1500 mg/kg AAE can be used as an alternative for antibiotic growth promoter replacement without negative effect on broiler performance. HIGHLIGHTS Artemisia annua L. aqueous extract can promote growth performance and antioxidant function of Broilers. Artemisia annua L. aqueous extract is expected to become the substitute for antibiotics and promote the growth of the body. The optimal dose range of Artemisia annua L. aqueous extract in diet of broilers was 1000-1500 mg/kg.

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“…Butyric acid products (including their acid and salt forms) have the potential to replace antibiotic growth promoters as feed additives [8,9]. Supplementation with butyric acid, for example, has been shown to stimulate animal growth by enhancing the proliferation, differentiation, and function of gut tissues in both healthy and sick animals [10].…”

Section: Introductionmentioning

confidence: 99%

Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning

Liu

Evans

et al. 2020

Preprint

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Background: There is increasing research interest in using short-chain fatty acids (SCFAs) including butyrate as potential alternatives to antibiotic growth promoters in animal production. This study was conducted to evaluate the effects of supplementation of sodium butyrate (SB) in milk and/or milk replacer on the growth performance, rumen fermentation, and serum antioxidant capacity and immunoglobins in dairy calves before weaning. Forty healthy female Holstein calves (4-day-old; 40 ± 5 kg of body weight) were housed in individual hutches and randomly allocated to 1 of 4 treatment groups (n = 10 per group). The control group was fed no SB (SB0), while the other three groups were supplemented with 15 (SB15), 30 (SB30), or 45 (SB45) g per day of SB mixed into milk and/or milk replacer. Results: The SB supplementation enhanced growth and improved feed conversion into body weight gain compared with the SB0 group. No significant effect on rumen pH; concentrations of NH3-N, individual and total VFAs; or acetate: propionate (A:P) ratio was found during the whole experimental period. The serum glutathione peroxidase activity was higher in the SB30 and SB45 groups compared with the SB0 group, and the serum level of maleic dialdehyde linearly decreased as the SB supplementation amount increased during the whole experiment. Not inﬂuence of SB supplementation was observed on serum concentrations of immunoglobulin A, immunoglobulin G, or immunoglobulin M during the whole experimental period. Conclusions: Under the conditions of this study, SB supplementation improved growth performance and antioxidant ability in pre-weaned dairy calves. We recommended 45 g per day as the optimal level of SB supplementation (mixed into milk and/or milk replacer) to improve the growth and antioxidant function of dairy calves before weaning.

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Influence of Butyrate Loaded Clinoptilolite Dietary Supplementation on Growth Performance, Development of Intestine and Antioxidant Capacity in Broiler Chickens

Cited by 47 publications

References 50 publications

Effect of early dietary energy restriction and phosphorus level on subsequent growth performance, intestinal phosphate transport, and AMPK activity in young broilers

Effect of early dietary energy restriction and phosphorus level on subsequent growth performance, intestinal phosphate transport, and AMPK activity in young broilers

Artemisia annua L. aqueous extract as an alternative to antibiotics improving growth performance and antioxidant function in broilers

Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning

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