Influence of cafeteria diet and fish oil in pregnancy and lactation on pups’ body weight and fatty acid profiles in rats

Sánchez-Blanco, Clara; Amusquivar, Encarnacíón; Bispo, Kenia; Herrera, Emílio

doi:10.1007/s00394-015-0992-0

Cited by 12 publications

(9 citation statements)

References 61 publications

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“…We have found that dams on a CAF diet had increased food intake in the second and the third week before pregnancy and in the second week of pregnancy when compared to C group. These findings are in agreement with data obtained by Sanchez‑Blanco et al, which have shown that female rats kept on a CAF diet 22 days before pregnancy and during pregnancy had higher food intake than control 48 .…”

Section: Discussionsupporting

confidence: 93%

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Matuszewska

Zalewski

Klimaszyk

et al. 2021

Sci Rep

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Abstract“Western diet” containing high concentrations of sugar and fat consumed during pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet in animals, a cafeteria (CAF) diet is used. We hypothesized that CAF diet given to rats before, and during pregnancy and lactation differently influences fat content, metabolic and inflammation profiles in offspring. Females were exposed to CAF or control diets before pregnancy, during pregnancy and lactation. At postnatal day 25 (PND 25), body composition, fat contents were measured, and blood was collected for assessment of metabolic and inflammation profiles. We have found that CAF diet lead to sex-specific alterations in offspring. At PND25, CAF offspring had: (1) higher percentage of fat content, and were lighter; (2) sex-specific differences in levels of glucose; (3) higher levels of interleukin 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α); (4) sex-specific differences in concentration of IL-6 and TNF-α, with an increase in CAF females; (5) higher level of IL-10 in both sexes, with a more pronounced increase in females. We concluded that maternal CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring. Above effects are sex-specific, with female offspring being more susceptible to the diet.

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Section: Discussionsupporting

confidence: 93%

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Matuszewska

Zalewski

Klimaszyk

et al. 2021

Sci Rep

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“…Also, energy intake of cafeteria fed dams did not differ from other groups during gestation in the current study. Similarly, one study reported that energy intakes of cafeteria fed dams were similar to other groups ( Ferro Cavalcante et al, 2014 ) whereas other studies showed higher energy intakes during gestation in cafeteria group ( Akyol, Langley-Evans & McMullen, 2009 ; Sánchez-Blanco et al, 2016 ; Vithayathil et al, 2018 ). The present study demonstrated that energy intake was not different between groups during lactation, which has been reported previously ( Ferro Cavalcante et al, 2014 ), but not in all studies ( Bayol, Farrington & Stickland, 2007 ; Speight et al, 2017 ; Vithayathil et al, 2018 ).…”

Section: Discussionmentioning

confidence: 78%

“…Many studies reported conflicting results about the birth weights of pups exposed to maternal cafeteria diets. Some have found no differences in birth weights ( Bayol, Simbi & Stickland, 2005 ; Chen et al, 2008 ; Speight et al, 2017 ; Kalem et al, 2018 ) whereas others have reported higher birth weights ( Bayol, Farrington & Stickland, 2007 ; Sánchez-Blanco et al, 2016 ; Vithayathil et al, 2018 ; Cardenas-Perez et al, 2018 ). Also, a meta regression analysis of animal models investigating the effect of maternal obesogenic diet exposure on birthweight demonstrated that this exposure had no effect on birthweight ( Ribaroff et al, 2017 ).…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies reported that ingestion of the cafeteria diet before pregnancy led to hyperphagia and increased energy intake ( Akyol, Langley-Evans & McMullen, 2009 ; Crew, Waddell & Mark, 2016 ; Sánchez-Blanco et al, 2016 ). Unlike this finding, energy intake of cafeteria fed dams did not differ from other groups prior to gestation in this study.…”

Section: Discussionmentioning

confidence: 99%

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Effects of maternal taurine supplementation on maternal dietary intake, plasma metabolites and fetal growth and development in cafeteria diet fed rats

Çetin¹,

Tuğ²,

Güleç³

et al. 2021

PeerJ

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Background Maternal obesity may disrupt the developmental process of the fetus during gestation in rats. Recent evidence suggests that taurine can exert protective role against detrimental influence of obesogenic diets. This study aimed to examine the effect of maternal cafeteria diet and/or taurine supplementation on maternal dietary intake, plasma metabolites, fetal growth and development. Methods Female Wistar rats were fed a control diet (CON), CON supplemented with 1.5% taurine in drinking water (CONT), cafeteria diet (CAF) or CAF supplemented with taurine (CAFT) from weaning. After 8 weeks all animals were mated and maintained on the same diets during pregnancy and lactation. Results Dietary intakes were significantly different between the groups. Both CAF and CAFT fed dams consumed less water in comparison to CON and CONT dams. Taurine supplementation only increased plasma taurine concentrations in CONT group. Maternal plasma adiponectin concentrations increased in CAF and CAFT fed dams compared to CON and CONT fed dams and there was no effect of taurine. Hyperleptinemia was observed in CAF fed dams but not in CAFT fed dams. Malondialdehyde was significantly increased only in CAF fed dams. Litter size, sex ratio and birth weight were similar between the groups. There was an increase in neonatal mortality in CONT group. Discussion This study showed that maternal taurine supplementation exerted modest protective effects on cafeteria diet induced maternal obesity. The increased neonatal mortality in CONT neonates indicates possible detrimental effects of taurine supplementation in the setting of normal pregnancy. Therefore, future studies should investigate the optimal dose of taurine supplementation and long term potential effects on the offspring.

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“…Although we cannot exclude the possibility of changes in body fat mass, our findings regarding their weight agree with those that gestational, pre‐gestational or post‐gestational cafeteria exposure decreased pups body weight at birth compared to the standard diet, without any significant differences in PND 21. Considering that gestational, pre‐gestational or post‐gestational exposure to cafeteria did not impact body weight in PND21 (Sánchez‐Blanco et al, 2016), it suggests this age is useful to identify behavioral and biochemical triggers in diet‐induced overeating before an overweight or an obesity status.…”

Section: Discussionmentioning

confidence: 99%

Early life exposure to hypercaloric diet impairs eating behavior during weaning: The role of BDNF signaling and astrocyte marks

Palazzo

Torres

Grefenhagen

et al. 2020

Intl J of Devlp Neuroscience

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Literature shows that gestational and/or lactational exposure to hypercaloric diets induces long term effects on eating behavior and the involvement of neurochemical mechanisms. We hypothesized that the effects of hypercaloric diets in early development phases can precede an overweight or an obesity status. The aim of the present study was to evaluate the impact of gestational and lactational exposure to cafeteria diet on eating behavior and neurochemical parameters, BDNF signaling, epigenetic and astrocyte marks in the hippocampus and olfactory bulb during the weaning phase. Pregnant female rats were randomized between standard and cafeteria diet, the respective diet was maintained through the lactational period. The framework of feeding pattern, meal, and its microstructure, was observed in postnatal day 20. Exposure to cafeteria diet increased the number of meals, associated with a lower first inter‐meal interval and higher consumption in both genders, without any changes in body weight. Diet exposure also reduced the number of grooming, a behavior typically found at the end of meals. Hypercaloric diet exposure reduced BDNF levels in the olfactory bulb and hippocampus from rats of both sexes and increased the content of the TrkB receptor in hippocampi. It was observed an increase in HDAC5 levels, an epigenetic mark. Still, early exposure to the hypercaloric diet reduced hippocampal GFAP and PPARγ levels, without any effect on NeuN content, indicating that alterations in astrocytes can precede those neuronal outcomes. Our results showed that changes in interrelated neurochemical signaling, BDNF, and astrocyte marks, induced by hypercaloric diet in early stages of development may be related to impairment in the temporal distribution of eating pattern and consequent amounts of consumed food during the weaning phase.

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Influence of cafeteria diet and fish oil in pregnancy and lactation on pups’ body weight and fatty acid profiles in rats

Abstract: The effect of CD and CD-FO decreasing pups body weight could be related to decreased concentrations of ARA, caused by the inhibition of the Δ(5) and Δ(6) desaturases in the pathway of n-6 LCPUFA biosynthesis.

Cited by 12 publications

References 61 publications

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Effects of maternal taurine supplementation on maternal dietary intake, plasma metabolites and fetal growth and development in cafeteria diet fed rats

Early life exposure to hypercaloric diet impairs eating behavior during weaning: The role of BDNF signaling and astrocyte marks

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