Influence of catheter insertion on the hemodynamic environment in coronary arteries

Tian, Xiaopeng; Sun, Anqiang; Xiao, Lan; Pu, Fang; Deng, Xiaoyan; Hj, Kang; Fan, Yubo

doi:10.1016/j.medengphy.2016.06.013

Cited by 12 publications

(18 citation statements)

References 53 publications

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“…It is very interesting and inspiring to find that the CVC-related thrombosis mainly occurred at sections where the flow lost most of its spiral rotation. In arterial systems, spiral blood flow has been suggested as a normal physiological flow phenomenon to protect the vessel wall from damage by reduction of the laterally directed forces, to facilitate the blood flow transportation, to prevent the accumulation of atherogenic low density lipoproteins on the luminal surfaces of arteries, and reduce the adhesion of blood cells on the arterial surface which protect the arteries from the pathology of thrombosis 14 , 15 . According to our preliminary results, the loss or marked reduction of spiral flow in the central veins after CVC insertion might be risk factors for thrombosis for patients undergoing hemodialysis.…”

Section: Discussionmentioning

confidence: 99%

“…However, inconsistent or conflicting results were reported in these studies regarding the association between the risk factors and CVC-related thrombosis 2 , 9 , 13 . As a matter of fact, up to now, the definite mechanism and risk factors responsible for the initiation and progression of CVC-related thrombosis remain unknown, so there is still no effective way to reduce the risk of thrombosis for CVC use in clinical practice 2 , 14 .…”

Section: Introductionmentioning

confidence: 99%

“…Tian et al . 14 reported that the insertion of a catheter into the coronary artery could cause marked increases of WSS and velocity in the left anterior descending (LAD) and increase the risk of platelet aggregation in LAD, which may make the coronary artery became more vulnerable to thrombus formation. The placement of CVC in the central veins follows a similar process to the insertion of a catheter into coronary arteries, and it is reasonable to speculate that the disturbed hemodynamics after the insertion of tunneled CVC may cause susceptible factors which can promote the thrombosis in ESRD patients.…”

Section: Introductionmentioning

confidence: 99%

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Numerical Simulation of Hemodynamic Changes in Central Veins after Tunneled Cuffed Central Venous Catheter Placement in Patients under Hemodialysis

Peng

Qiu

Huang

et al. 2017

Sci Rep

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The tunneled central venous catheter (CVC) plays an important role for hemodialysis patients, but CVC-related thrombosis in the central veins remain problematic. This study is the first try to numerically find out what hemodynamic parameters are predisposed to the initiation and formation of thrombus after CVC insertion. And the potential relationship between hemodynamic parameters and the incidence rates of thrombosis occurrence was explored. The results revealed that the CVC insertion led to a significant increase of hydraulic resistance, wide-ranging abnormally high wall shear stress (WSS), and a great loss of flow rotation in the vein. Moreover, the clinical data showed that thrombosis mainly occurred at sections where most blood flow lost spiral rotation after the CVC insertion, but no corresponding match was observed between the occurrence of thrombosis and the flow velocity or WSS. We speculate that the destruction of the flow rotation in the central vein is a precursor to the thrombus formation around CVC, and an introduction of spiral flow with the CVC insertion may possibly help to protect the central vein from thrombosis. Further animal and clinical experiments should be carried out to test and verify this speculation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Numerical Simulation of Hemodynamic Changes in Central Veins after Tunneled Cuffed Central Venous Catheter Placement in Patients under Hemodialysis

Peng

Qiu

Huang

et al. 2017

Sci Rep

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“…As a branch of hydrodynamics, CFD is increasingly being applied in biomedical engineering. Many bioengineers have used CFD to study complex cardiovascular diseases, such as coronary artery stenosis [21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Influence of malformation of right coronary artery originating from the left sinus on the hemodynamic environment

Cong

Qiu

et al. 2020

Preprint

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Background: The Anomalous origin of the Right Coronary Artery (RCA) from the Left Coronary artery sinus(AORL) is one of the abnormal origins of the coronary arteries. Most of these issues seldom have effects on human health, but some individuals may have symptoms such as myocardial ischaemia or even sudden death. Recently, researchers are studying AORL through clinical cases, but study based on computational fluid dynamics (CFD) is rarely seen. In this study, haemodynamic changes between normal origin of the RCA and AORL are compared according to numerical simulation results.Methods: Realistic three-dimensional models of 16 normal right coronary arteries and 26 abnormal origins of the right coronary arteries were reconstructed, respectively. The blood flow was numerically simulated using software ANSYS. This study involves one-way fluid-solid coupling finite element model in which the blood is assumed to be incompressible Newtonian fluid, and the vessel is assumed to be isotropic, linear elastic material. Results: The differences of the cross-sectional area at the inlet between the normal group and the abnormal group was significant (P<0.0001). There were significant differences in the volumetric flow (P=0.0001) and pressure (P=0.0002). There were positive correlations with the ratio of the cross-sectional area of the RCA to the inlet area of the ascending aorta (AAO) and the ratio of the inlet volumetric flow of the RCA to the volumetric flow of the AAO, in both the normal (P=0.0001, r=0.8178) and abnormal (P=0.0033, r=0.6107) group.Conclusion: This study shows that the cross-sectional area of the inlet of AORL may cause ischaemia symptoms, and the results may contribute to the further understanding of the clinical symptoms of AORL based on the haemodynamics.

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“…However, a reduction in friction also decreases the degree of haptic feedback, which provides the surgeon with valuable information about the progress of the procedure. In addition, the insertion of a catheter can increase the risk of platelet aggregation in blood flow [5], but, in most cases, the patient is provided with an appropriate dosage of heparin. Damage to the extracellular matrix (ECM) will require a wound healing response and if it goes wrong this can lead to fibrosis [6].…”

Section: Introductionmentioning

confidence: 99%

Measurement of Friction-induced Changes in Pig Aorta Fibre Organization by Non-invasive Imaging as a Model for Detecting the Tissue Response to Endovascular Catheters

et al. 2017

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Influence of catheter insertion on the hemodynamic environment in coronary arteries

Cited by 12 publications

References 53 publications

Numerical Simulation of Hemodynamic Changes in Central Veins after Tunneled Cuffed Central Venous Catheter Placement in Patients under Hemodialysis

Numerical Simulation of Hemodynamic Changes in Central Veins after Tunneled Cuffed Central Venous Catheter Placement in Patients under Hemodialysis

Influence of malformation of right coronary artery originating from the left sinus on the hemodynamic environment

Measurement of Friction-induced Changes in Pig Aorta Fibre Organization by Non-invasive Imaging as a Model for Detecting the Tissue Response to Endovascular Catheters

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