Influence of Cdx2 and TaqI Gene Variants on Vitamin D 3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis

Harishankar, M.; Selvaraj, P.

doi:10.1016/j.clinthera.2017.04.003

Cited by 10 publications

(5 citation statements)

References 40 publications

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“…Apart from osteoporosis, CdX-2 polymorphism also plays an important role in immune-related conditions. CdX-2 AA is associated with an increased risk for tuberculosis and overall risk for cancer [20,21]. Modulation of transcription activity, as described in previous studies, may explain the findings of our study that revealed the CdX-2 G/A genotype as a potential predictor of IC status.…”

Section: Plos Onesupporting

confidence: 83%

The association between vitamin D receptor polymorphism and phases of chronic hepatitis B infection in HBV carriers in Thailand

et al. 2022

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Vitamin D receptor (VDR) polymorphism partly regulates the immune system and is associated with hepatic flare in chronic Hepatitis B virus infection (HBV). Our study identified the association between two distinct phases, VDR polymorphisms and HBV inactive carrier (IC) and chronic hepatitis (CH). Chronic HBV patients were enrolled from February to August 2020. An HBV viral load (VL) < 2,000 IU/ml twice for 6 months apart, with no prior history of HBV treatment, defined the IC phase. Six common polymorphisms in the VDR gene, including CdX-2, GATA, FokI, Bsml, ApaI, and TaqI, were studied using real-time PCR. The different outcomes in allele, genotype, and haplotype frequencies in between groups and linkage disequilibrium (LD) mapping were analyzed. Among 324 enrolled patients, there were 163 patients in IC and 161 patients in CH phases. The mean vitamin D levels were not statistically different between groups. The proportion of allele frequencies of CdX-2 in IC and CH was 53.7% and 62.7% for G allele, and 46.3% and 37.3% for A allele (p 0.019). The proportion of GG genotype of CdX-2 was less frequently found in patients with IC compared to that in patients with CH (27% vs 41%, p 0.028). By multivariate analysis, CdX-2 G/A genotypes were independently associated with IC, with adjusted odd ratio (OR) 1.83 (1.10–3.04), p 0.019. The LD mapping of single nucleotide polymorphisms (SNP) revealed high LD scores in Bsml/ApaI/TaqI (BAT) haplotype in both groups while, CdX-2/GATA and GATA/FokI demonstrated high LD score only in CH group. CdX-2 G/A genotypes were independently associated with IC status in Thai patients with chronic HBV infection. The difference in LD of the CdX-2/GATA and GATA/FokI haplotypes in between groups may represent a non-random selection resulting in the variation of immune control.

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Section: Plos Onesupporting

confidence: 83%

The association between vitamin D receptor polymorphism and phases of chronic hepatitis B infection in HBV carriers in Thailand

et al. 2022

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“…Rs11568820 (Cdx2) VDR SNP was not assessed in AITD patients to date (according to the PubMed database, 31.04.2019). This SNP was previously shown to influence the immune system and modify the risk of some infectious diseases (e.g., tuberculosis and rubella) [17, 37, 38]. However, we did not observe a significant association between rs11568820 SNP and AIT risk.…”

Section: Discussioncontrasting

confidence: 94%

Vitamin D Receptor Gene Polymorphisms and Autoimmune Thyroiditis: Are They Associated with Disease Occurrence and Its Features?

Maciejewski

Kowalczyk

Herman³

et al. 2019

BioMed Research International

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Purpose. Vitamin D, besides its role in calcium-phosphorus metabolism, turned out to play a significant immunomodulating function. Until now four single nucleotide polymorphisms of vitamin D receptor gene (VDR), rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI), have been studied in autoimmune thyroid disorders, with conflicting results. Another functional polymorphism of the VDR gene, rs11568820 (Cdx2), has been shown to influence the immune system, although it has not been studied for its association with autoimmune thyroiditis to date. Therefore, the study aimed to evaluate the association of these five VDR gene polymorphisms with susceptibility to autoimmune thyroiditis among Caucasian Polish population. A relationship between the studied polymorphisms and selected clinical features of the disease was additionally assessed. Methods. 223 patients with autoimmune thyroiditis and 130 control subjects were enrolled in the study. VDR polymorphisms were studied by PCR-RFLP or TaqMan real-time PCR. Results. Allele and genotype distributions of any of the studied polymorphisms did not differ significantly between patients and controls. Similarly, frequencies of haplotypes derived from rs1544410-rs7975232-rs731236 (BsmI-ApaI-TaqI) polymorphisms were not significantly different in the two studied groups. However, a weak association between rs1544410 (BsmI) or rs7975232 (ApaI) VDR polymorphisms and thyroid volume was found (p = 0.03 and p = 0.04, resp.). Conclusions. Our results suggest that VDR gene is not a major susceptibility factor for autoimmune thyroiditis development, at least in Caucasian Polish population.

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“…Nevertheless, no substantial link has been established between this SNP and autoimmune disorders such as T1D, MS, vitiligo, or psoriasis ( Dickinson et al, 2009 ; Zhou et al, 2014 ; Frederiksen et al, 2013 ; Aydıngöz et al, 2012 ). Although it is uncertain why the polymorphism is connected to illnesses like tuberculosis, numerous studies have connected this association to VDR methylation, vitamin D-mediated control of chemokine-positive T cells, and impact adaptive cytokine responses ( Meyer and Bornman, 2018 ; Ovsyannikova et al, 2010 ; Harishankar and Selvaraj, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

Abdollahzadeh

Shushizadeh

Barazandehrokh

et al. 2021

Infection, Genetics and Evolution

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Introduction Growing evidence documented the critical impacts of vitamin D (VD) in the prognosis of COVID-19 patients. The functions of VD are dependent on the vitamin D receptor (VDR) in the VD/VDR signaling pathway. Therefore, we aimed to assess the association of VDR gene polymorphisms with COVID-19 outcomes. Methods In the present study, eight VDR single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 500 COVID-19 patients in Iran, including 160 asymptomatic, 250 mild/moderate, and 90 severe/critical cases. The association of these polymorphisms with severity, clinical outcomes, and comorbidities were evaluated through the calculation of the Odds ratio (OR). Results Interestingly, significant associations were disclosed for some of the SNP-related alleles and/or genotypes in one or more genetic models with different clinical data in COVID-19 patients. Significant association of VDR-SNPs with signs, symptoms, and comorbidities was as follows: Apa I with shortness of breath (P ˂ 0.001) and asthma (P = 0.034) in severe/critical patients (group III); Bsm I with chronic renal disease (P = 0.010) in mild/moderate patients (group II); Tru9I with vomiting (P = 0.031), shortness of breath (P = 0.04), and hypertension (P = 0.030); Fok I with fever and hypertension (P = 0.027) in severe/critical patients (group III); CDX2 with shortness of breath (P = 0.022), hypertension (P = 0.036), and diabetes (P = 0.042) in severe/critical patients (group III); Eco RV with diabetes (P ˂ 0.001 and P = 0.045 in mild/moderate patients (group II) and severe/critical patients (group III), respectively). However, the association of VDR TaqI and Bgl I polymorphisms with clinical symptoms and comorbidities in COVID-19 patients was not significant. Conclusion VDR gene polymorphisms might play critical roles in the vulnerability to infection and severity of COVID-19, probably by altering the risk of comorbidities. However, these results require further validation in larger studies with different ethnicities and geographical regions.

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Influence of Cdx2 and TaqI Gene Variants on Vitamin D 3 Modulated Intracellular Chemokine Positive T-Cell Subsets in Pulmonary Tuberculosis

Cited by 10 publications

References 40 publications

The association between vitamin D receptor polymorphism and phases of chronic hepatitis B infection in HBV carriers in Thailand

The association between vitamin D receptor polymorphism and phases of chronic hepatitis B infection in HBV carriers in Thailand

Vitamin D Receptor Gene Polymorphisms and Autoimmune Thyroiditis: Are They Associated with Disease Occurrence and Its Features?

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

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