Influence of chemical species on the determination of arsenic using inductively coupled plasma mass spectrometry at a low liquid flow rate

Grotti, Marco; Ardini, Francisco; Terol, Amanda; Magi, Emanuele; Todolı́, José-Luis

doi:10.1039/c3ja50159k

Cited by 16 publications

(15 citation statements)

References 33 publications

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“…One approach for standard-less quantification is to assume that the ICP-MS response for As is independent of the type of As species; one can then use a commercially available As species to prepare the calibration curve to calculate the needed concentration. Although ICP-MS sensitivity has been shown to vary somewhat from species to species (Grotti et al 2013), this approach easily generates approximate values which are often sufficient-for-purpose. A more labor intensive (also more accurate) approach is to isolate individual species via fraction collection and determine the total As content in the fraction using a method that measures As without regard to the molecule it’s incorporated into, such as instrumental neutron activation analysis (INAA), although the practicality of this approach is limited (Yu et al 2015).…”

Section: Analytical/monitoring Considerationsmentioning

confidence: 99%

Human exposure to organic arsenic species from seafood

Taylor

Goodale

Raab

et al. 2017

Science of The Total Environment

395

256

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Seafood, including finfish, shellfish, and seaweed, is the largest contributor to arsenic (As) exposure in many human populations. In contrast to the predominance of inorganic As in water and many terrestrial foods, As in marine-derived foods is present primarily in the form of organic compounds. To date, human exposure and toxicological assessments have focused on inorganic As, while organic As has generally been considered to be non-toxic. However, the high concentrations of organic As in seafood, as well as the often complex As speciation, can lead to complications in assessing As exposure from diet. In this report, we evaluate the presence and distribution of organic As species in seafood, and combined with consumption data, address the current capabilities and needs for determining human exposure to these compounds. The analytical approaches and shortcomings for assessing these compounds are reviewed, with a focus on the best practices for characterization and quantitation. Metabolic pathways and toxicology of two important classes of organic arsenicals, arsenolipids and arsenosugars, are examined, as well as individual variability in absorption of these compounds. Although determining health outcomes or assessing a need for regulatory policies for organic As exposure is premature, the extensive consumption of seafood globally, along with the preliminary toxicological profiles of these compounds and their confounding effect on assessing exposure to inorganic As, suggests further investigations and process-level studies on organic As are needed to fill the current gaps in knowledge.

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Section: Analytical/monitoring Considerationsmentioning

confidence: 99%

Human exposure to organic arsenic species from seafood

Taylor

Goodale

Raab

et al. 2017

Science of The Total Environment

395

256

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“…As(III), As(V) and AB) have different ICPMS responses [202,203]. Some authors report that different As species ( e.g.…”

Section: Icpms and Afs Considerationsmentioning

confidence: 99%

Measurement of arsenic species in environmental, biological fluids and food samples by HPLC-ICPMS and HPLC-HG-AFS

Maher

Ellwood

Krikowa

et al. 2015

J. Anal. At. Spectrom.

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The importance of measuring arsenic (As) species has been appreciated for a long time mainly because of the wide spread knowledge of arsenic's toxicity and its use as a poison. Increasingly health, environmental and food regulations have been written around As species rather than total concentrations. Knowledge of As speciation is important as the chemical form of As controls its bioavailability, toxicity, mobility and therapeutic benefits. Arsenic is present as inorganic (arsenate, arsenite, thioarsenates), complexed (arsenic glutathionines and phytochelatins), low molecular weight (monomethylarsonate, dimethylarsenite, arsenobetaine, arsenocholine etc.) and high molecular weight ( arsenic hydrocarbons and arsenic phospholipids) species. In this review we cover the intergrity of As species during collection, storage, sample preparation and measurement by HPLC-ICPMS and HPLC-HG-AFS. The major conclusion is that it is essential to ensure that As species, especially in waters and sediments, are not artefacts of the preservation or extraction procedure. Most biota and sediment samples can be stored frozen (-20 o C), but the stability of water and sediment samples is matrix dependent and depends on preservation technique applied. Arsenic cannot be extracted from samples using a single set of conditions but must be optimised for each sample type. Methanol-water mixtures with microwave heating are commonly used to extract polar As species from tissues while As-lipids required a non-polar solvent. Dilute acid can be used to increase the efficiencies of extraction of hard to extract tissue As species. Freeze drying is suitable for the drying of biotic material while sediments should not be dried before analysis. Extraction efficiencies are critically dependent on particle size. Polar As species have a wide variety of ionic characteristics thus complimentary chromatographic 4 Understanding the action of a chemical species in a food stuff or nutritional supplement: As mentioned above, some food regulations require specification of the active ingredient of foodstuffs or supplements. However, another important reason for determining the chemical species is to understand the beneficial action of an element. For example, many food stuffs are promoted for their anti-carcinogenic activity [8]. Evaluation of the role of As in preventing cancers has required the active species to be identified [8,9].Increasingly health, environmental and food regulations have been written around a knowledge of As species rather than total concentrations. In the environment, As is present as inorganic (arsenate (As(V)), arsenite (As(III)), thioarsenates), complexed, (As glutathionines (AsGSH) and phytochelatins (AsPC)), low molecular weight [monomethylarsonate (MA), dimethylarsenite (DMA), arsenobetaine (AB), arsenocholine (AC) etc.] and higher molecular weight (As hydrocarbons and As phospholipids) species (Table 1). Volatile As species (TMAs, As-hydrides) are also produced by bacteria and fungi [10,11].Arsenic is present in all organisms, but is ...

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“…Up to now, a variety of analytical methods have been employed for detection of As, Se and Te in water, such as AAS [21,28], atomic fluorescence spectrometry (AFS) [30,31], inductively coupled plasma optical emission spectrometry (ICP-OES) [32] and ICP-MS [33][34][35]. Among these techniques, ICP-MS is widely employed due to its merits of high sensitivity, wide linear range, multi-element and multi-isotope detection.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous speciation of inorganic arsenic, selenium and tellurium in environmental water samples by dispersive liquid liquid microextraction combined with electrothermal vaporization inductively coupled plasma mass spectrometry

Liu

Chen

et al. 2015

Talanta

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Influence of chemical species on the determination of arsenic using inductively coupled plasma mass spectrometry at a low liquid flow rate

Abstract: PAPERMarco Grotti et al.Infl uence of chemical species on the determination of arsenic using inductively coupled plasma mass spectrometry at a low liquid fl ow rate

Cited by 16 publications

References 33 publications

Human exposure to organic arsenic species from seafood

Human exposure to organic arsenic species from seafood

Measurement of arsenic species in environmental, biological fluids and food samples by HPLC-ICPMS and HPLC-HG-AFS

Simultaneous speciation of inorganic arsenic, selenium and tellurium in environmental water samples by dispersive liquid liquid microextraction combined with electrothermal vaporization inductively coupled plasma mass spectrometry

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