Influence of chemically and biosynthesized silver nanoparticles on in vitro viability and infectivity of Trichinella spiralis muscle larvae

Dyab, Ahmed K.; Abd-ELrahman, Salwa Mahmoud; Mahmoud, Amal; Elossily, Nahed Ahmed; Alsharif, Fahd M.; Mohamed, Samia; Abomughaid, Mosleh M.

doi:10.1101/2020.12.17.423206

Cited by 7 publications

(10 citation statements)

References 45 publications

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“…HCl+ 1L of distilled water and stirred to about 10 minute) in conical flask at 37°C overnight. Filtration to larvae by using thieve to remove bones and then washed several times with PBS, and their number/ ml was counted under a light microscope X40 according to (Abd-Elrahman et al, 2021).…”

Section: Animalsmentioning

confidence: 99%

Evaluation of Clinicopathological alterations in mice experimentally infected with Trichenella spiralis and the Nematocidal effect of Tannic acid and Albendazole

Swilam

Nasreldin²,

Abd-Elrahman³

et al. 2022

New Valley Veterinary Journal

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Trichinella spiralis (T. spiralis) is one of the parasitic nematodes of a highly zoonotic importance. It infects various vertebrates, including human. In this study eighty (n =80) Swiss albino mice were experimentally infected by T. spiralis to assess the nematocidal activity of tannic acid (TA) and albendazole (ABZ) individually or in combination during the intestinal phase of T. spiralis. Mice were divided into 10 equal groups 8 mice for each, (control): noninfected but received saline, (ABZ): non-infected and treated with ABZ 50 mg/kg, (TA1000): non-infected and treated with TA1000 µg/ml, (TA2000): non-infected and treated with TA2000 µg/ml, (ABZ+TA2000): non-infected and treated with ABZ 50 mg/kg + TA2000 µg/ml , (TS): infected non treated, (TS+ABZ) group: infected and treated with ABZ 50mg/kg, (TS+TA1000): infected and treated with TA1000 µg/ml, (TS+TA2000): infected and treated with TA2000 µg/ml and (TS+ABZ+TA2000): infected and treated with ABZ 50mg/kg + TA2000 µg/ml. Mice were sacrificed at 7 th day post infection. Results demonstrated significant reductions in the adult worm count in TS+TA1000, TS+ABZ, TS+ TA2000 and TS+ABZ+TA2000 with efficacies of 91%, 92%, 92% & 99% respectively. Results were confirmed by histopathological examination of the targeted organs. The degree of necrosis was decreased in treated groups, associated with reduction in the percentage of eosinophils. Elevated concentrations of serum ALT, AST, and urea in the infected group were decreased in treated groups, while albumin and glucose were increased.It was concluded that the combined albendazole-tannic acid therapy had the highest effect on reducing parasite burden and restoring normal histological architecture.

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Section: Animalsmentioning

confidence: 99%

Evaluation of Clinicopathological alterations in mice experimentally infected with Trichenella spiralis and the Nematocidal effect of Tannic acid and Albendazole

Swilam

Nasreldin²,

Abd-Elrahman³

et al. 2022

New Valley Veterinary Journal

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“…Moreover, this high mortality rate was also achieved by biosynthesized NPs at a concentration of 5 μg/ml. Additionally, a complete inhibition of the larval infectivity was reported after 24 h exposure to sub lethal doses of chemical and myrrh prepared AgNPs [95] .…”

Section: Trichinella Spiralismentioning

confidence: 94%

Potential applications of inorganic silver nanoparticles (AgNPs) in parasitic diseases

Gomaa

2022

Parasitologists United Journal

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Parasitic diseases are globally distributed, leading to considerable morbidity and mortality especially in low and middle-income countries. The current treatment strategies of parasitic infections face hard challenges due to emergence of drug resistance and intolerable side effects. Therefore, the development of novel, safe and effective anti-parasitic agents is urgently required. In this context, nanomaterials represent an efficient tool to overcome the barriers observed in several conventional therapeutics. Nanotechnology has efficiently provided tools enabling structural modifications in chemical compounds, empowering their highly desirable selectivity and specificity. Among them, metal nanoparticles (NPs) have been significantly utilized as an alternative therapeutic approach and/or efficient delivery system in a wide range of parasitic diseases. Due to its extraordinary range of bactericidal properties and therapeutic abilities, AgNPs have become a part of medical management of various diseases. Moreover, a number of plant species successfully employed in AgNPs green synthesis, are ecofriendly efficient alternatives to chemically synthesized NPs. The current review aims to shed light on AgNPs regarding their physiochemical properties, synthesis methods, and potential applications in diagnosis, treatment, and protection against parasitic infections. Concerning the last issue, their insecticidal activities paved the way for prevention of transmission of vector borne parasitic diseases.The present review is intended to shed light on one of the important members of inorganic metal NPs, the "AgNPs", regarding the physiochemical properties, the different methods of synthesis, the diagnostic applications in parasitic infections, the in vitro and in vivo anti-parasitic activities, the drug-delivery properties and finally the preventive potentials. Different medically important parasites, affected by AgNPs are listed in this review. Plants that were successfully used in green synthesis of AgNPs are also listed. Selected articles were gathered from Medline (PubMed), Scopus, Science Direct, Web of Science and Google Scholar using the keywords:

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“…Objects between 1 and 100 nm in size are considered nanoparticles, and they may have unique properties compared to the bulk material. Copper, zinc, titanium, magnesium, gold, alginate, and silver are just some of the metals now being utilized in the creation of these nanostructures (19) . Nanoparticles, because of their extraordinary qualities, have recently gained attention in numerous industries.…”

Section: ) Nanoparticles (Nps)mentioning

confidence: 99%

“…Nanoparticles, because of their extraordinary qualities, have recently gained attention in numerous industries. The ability of nanoparticle technologies to transform physiologically active chemicals that are poorly soluble, poorly absorbed, and easily degraded into viable deliverable substances is extremely promising (19) .…”

Section: ) Nanoparticles (Nps)mentioning

confidence: 99%

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Updated Treatment Modalities of Trichinellosis: Review Article

Mohamed¹,

Taha²,

Hamed³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Trichinellosis is a food borne widespread zoonotic pathogen distributed all over the world, Trichnella spiralis (T. spiralis) is the most popular species to cause the disease. Medications such as anthelmintics (mebendazole or albendazole) and glucocorticosteroids are used to treat the condition. Objective: This review article aimed to assess the updated treatment modalities of trichinellosis. Methods: We searched PubMed, Google Scholar, and Science Direct for information on Trichinellosis with treatment. However, only the most current or comprehensive study from May 2006 to May 2022 was considered. The authors also assessed references from pertinent literature. Documents in languages other than English have been disregarded since there aren't enough resources for translation. Unpublished manuscripts, oral presentations, conference abstracts, and dissertations were examples of papers that weren't considered to be serious scientific research. Conclusion:Trichinellosis treatment presents a number of challenges. During the time of intestinal invasion, anthelmintics are required (i.e., less than 1 week after infection). Treatment is typically initiated at the earliest stages of larval development in muscle cells, but this is rarely attainable. Efforts to improve Trichinellosis treatments by the use of pharmaceuticals are the target. Mebendazole and albendazole are the most often used medications for treating trichinellosis. Pyrantel is safe for usage by pregnant women and children. The bacterium Streptomyces avermitilis is responsible for producing ivermectin, which is then classified as a macrocyclic lactone.

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Influence of chemically and biosynthesized silver nanoparticles on in vitro viability and infectivity of Trichinella spiralis muscle larvae

Cited by 7 publications

References 45 publications

Evaluation of Clinicopathological alterations in mice experimentally infected with Trichenella spiralis and the Nematocidal effect of Tannic acid and Albendazole

Evaluation of Clinicopathological alterations in mice experimentally infected with Trichenella spiralis and the Nematocidal effect of Tannic acid and Albendazole

Potential applications of inorganic silver nanoparticles (AgNPs) in parasitic diseases

Updated Treatment Modalities of Trichinellosis: Review Article

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