Influence of Childhood and Adulthood Obesity on Arterial Stiffnes and Central Blood Pressure in Men

Isaykina, O. Yu.; Rozanov, V. B.; Alexandrov, A. A.; Иванова, Е. И.; Pugoeva, H. S.

doi:10.20996/1819-6446-2018-14-4-543-551

Cited by 3 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Атеросклеротический процесс, приводящий к сердечно-сосудистым заболеваниям, начинается в детском и подростковом возрасте и развивается на протяжении жизни под влиянием генетических и модифицируемых факторов риска [2]. Результаты проспективных исследований свидетельствуют об исключительной важности активного наблюдения детей с избыточной массой тела, ожирением и повышенным артериальным давлением для профилактики раннего развития артериальной гипертонии [3][4][5]. Для управления факторами риска необходимы сведения об истинной эпидемиологической ситуации в целом по стране и на региональном уровне.…”

unclassified

Prevalence of risk factors of cardiovascular diseases in children and adolescents based on the data from health centers

Trunina

Буланова

Shchelykalina

et al. 2021

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

Цель исследования. Оценка распространенности избыточной массы тела, ожирения, повышенного артериального давления и гиперхолестеринемии у детей и подростков -посетителей центров здоровья. Характеристика детей и методы исследования. В одномоментном ретроспективном исследовании использованы данные длины и массы тела, артериального давления, уровня общего холестерина в свежей цельной капиллярной крови 70 001 ребенка (36 097 мальчиков) в возрасте 6-17 лет из 17 регионов Российской Федерации. Избыточную массу тела и ожирение определяли по диагностическим критериям Всемирной организации здравоохранения, по таблицам z-score индекса массы тела, учитывая пол и возраст. Гиперхолестеринемию диагностировали при уровне общего холестерина >5,2 ммоль/л, повышенное артериальное давление -при уровне систолического и/или диастолического артериального давления >95‰ кривой распределения артериального давления в популяции для соответствующего возраста, пола и роста. Результаты. Распространенность избыточной массы тела, ожирения, повышенного артериального давления и гиперхолестеринемии составила соответственно 18,2, 6,9, 5,2 и 3,0% у мальчиков и 15,9, 5,3, 4,8 и 4,1% у девочек. Частота выявления гиперхолестеринемии превышала стандартизованные показатели по 17 регионам Российской Федерации (3,5%) в Пермском крае (18,8%), Чувашской республике (6,9%) и Владимирской области (8,5%). Максимальная частота выявления избыточной массы тела и ожирения наблюдалась в Пермском крае -39,1% и 17,1%. Распространенность повышенного артериального давления превышала стандартизованные показатели по 17 регионам Российской Федерации (4,9%): в 2 раза -в Воронежской области (10,6%) и в 3 раза в регионе ХМАО-Югра (15,2%). Заключение. Полученные данные свидетельствуют о необходимости усиления мероприятий по профилактике сердечно-сосудистых заболеваний, изменению образа жизни и пищевых привычек в регионах России с высокой распространенностью изученных факторов риска развития сердечно-сосудистых осложнений начиная с детского и подросткового возраста.

show abstract

unclassified

Prevalence of risk factors of cardiovascular diseases in children and adolescents based on the data from health centers

Trunina

Буланова

Shchelykalina

et al. 2021

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

show abstract

EVA syndrome and hypertension in young people according to the work of the University Health Center of the StSMU

Evsevyeva,

Sergeeva,

Kudryavtseva

et al. 2023

Arter. gipertenz.

View full text Add to dashboard Cite

Relevance. There is still a discussion about what is primary and what is secondary — an increase in blood pressure (BP) or vascular remodeling.Objective. To assess the occurrence of isolated cases of Early Vascular Aging (EVA) syndrome and in combination with arterial hypertension/prehypertension in young people, taking into account body mass (BM) and manifestations of connective tissue insufficiency (CTI).Design and methods. In total, 346 people aged 18 to 25 years (131 boys or 37,9 % and 215 girls or 62,1 %) were examined. At first, the examined persons were divided into tercile-groups according to the indicator of vascular stiffness (VS) — the cardio-ankle vascular index (CAVI) (VaSera VS-1500N, Fucuda Denshia, Japan). VS is regarded as the main determinant of vascular aging. The upper CAVI-tercile of this distribution among persons of the same sex and age corresponds to the EVA-syndrome. The first tercile corresponds to the favorable and the average one corresponds to normal vascular aging. Then the association of these aging phenotypes with the level of BP, BM and the severity of signs of CTI was analyzed. The control group comprised normotonic representatives of the first and second CAVI-tercile groups. Data processing was carried out using the software package “Statistica 10.0” (StatSoftInc, USA).Results. In boys and girls, the incidence of isolated increases in VS is 16,8 % and 26,5 %, in combination with increased BP — 17,6 % and 6,5 %, isolated increases in BP — 39,6 % and 14,0 %, and normotension in combination with preserved elastic potential — 26,0 % and 53,0 %. Among normotonic boys and girls of isolated elevated VS, persons with excessive BM accounted for 14,8 % and 4,9 %, and with insufficient BM — 48,2 % and 29,5 %, respectively. The latter persons were characterized by a significantly higher number of signs of CTI compared to the control. And among the boys and girls of increased BP without an increase in VS, on the contrary, persons with excess BM and obesity are prevalent.Conclusions. Among young people, cases of increased VS are not always combined with such traditional risk factors as high BP and obesity, which is due to the so-called youth “obesity paradox”, as well as CTI. In preventive examinations of young people, differential diagnosis of the true EVA-syndrome with CTI should be performed, in the latter VS may increase due to the development of dysplastic-associated angiopathy. It is essential for the correct selection of cardio-vascular risk groups and further individualized preventive interventions among young people.

show abstract

Preventive Screening of Young People from the Perspective of Vascular Aging Phenotypes: the Role of Body Weight

Evsevyeva¹,

Eremin

Rostovtseva³

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

Aim. To study the cardiovascular stiffness index CAVI in relation to main risk factors (RF) in young people from the point of their vascular aging phenotype and gender.Material and methods. 264 young people (93 boys and 171 girls) at age of 18 to 25 years were examined. Vascular screening was performed with evaluating of CAVI. All subjects were divided into tertile groups for this indicator, taking into account gender. Such interval analysis of gender- and age- homogeneous sample allows to identify carriers of the phenotypes of premature (upper CAVI-tercile), normal (middle CAVI-tercile), and favorable or healthy (low CAVI-tercile) vascular aging. The first of them is also called EVA (early vascular aging) syndrome. In these groups, the incidence of carriers of insufficient, normal body mass (BM) and overweight were estimated. In three groups formed by BM indicator, the parameters of CAVI, hemodynamic and metabolic status in response to changes in BM were determined.Results. Among of the presented RF, the correlation was significant for CAVI with a weight -0.428 (p<0.001) for R-CAVI, -0.453 (p<0.001) for L- CAVI, and even more significant with the BM index - at the level of -0.410 (p<0.001) for R-CAVI and -0.462 (p<0.001) for L-CAVI. This connection is found in boys. Among boys and girls with excessive BM, the most favorable vascular aging phenotype is observed 2.7 and 2.2 times more often than the EVA syndrome. In contrast, among girls with insufficient BM, a favorable vascular phenotype is detected almost twice rarely as compared with EVA syndrome. In similar group of boys, a healthy vascular phenotype is not observed at all. Among normal-weight boys and girls, the occurrence of the two extreme vascular phenotypes is almost identical. The arterial rigidity decrease on the background of BM increase occurs despite the сhanges of hemo- dynamic and metabolic indicators. This changes are especially pronounced in girls. The difference between the extreme weight categories in terms of R- CAVI and L-CAVI for boys was 1.4, while for girls it was only 0.3 for R-CAVI and 0.4 for L-CAVI.Conclusion. When carrying out preventive measures among young people, one should not limit oneself to evaluating only traditional RF. Based on the concept of vascular aging, angiological screening should be more widely implemented. It will allow for more individualized preventive interventions among young people in the future.

show abstract

Influence of Childhood and Adulthood Obesity on Arterial Stiffnes and Central Blood Pressure in Men

Cited by 3 publications

References 25 publications

Prevalence of risk factors of cardiovascular diseases in children and adolescents based on the data from health centers

Prevalence of risk factors of cardiovascular diseases in children and adolescents based on the data from health centers

EVA syndrome and hypertension in young people according to the work of the University Health Center of the StSMU

Preventive Screening of Young People from the Perspective of Vascular Aging Phenotypes: the Role of Body Weight

Contact Info

Product

Resources

About