No abstract

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Health of the Russian Federation, Stavropol State Medical University Background. The relationship of arterial stiffness, which is  marker of vascular age, with main risk factors (RF) was studied mainly in adults and  elderly. It was shown that in this age group,  presence of major RF, including obesity, leads to increased rigidity of  artery wall.  Purpose -  to evaluate associations of various body mass (BM) with vascular stiffness and some RF in young people. Material and methods. Within  framework of the National Preventive Project  "University – Healty Territory", 264 students (93 boys and 171 girls) aged 18-25 years were evaluated for  profile of metabolic RF (total cholesterol (TC), low-density lipoproteins (LDL), triglycerides (TG), high-density lipoproteins (HDL), glucose) and blood pressure (BP). Vascular stiffness was  determined by using  cardio-ankle vascular index (CAVI), which was measured with diagnostic complex VaSera-1500 (Fucuda Denshi, Japan). This indicator, unlike others, does not depend on  level of  BP acting on  arterial wall at time of pulse wave registration. Since the values on left side were higher than on the right, the results are presented according to CAVI-L. Students were divided into groups according to  BM-index: 1group - insufficient BM; 2 group – normal BM and 3 group – overweight. Data processing was performed using software package "Statistica 10.0" (StatSoft Inc, USA). Results. It turned out  CAVI values in  three observation groups, formed by  BM indicator, in boys averaged 6.8 ±0.2, 5.9 ± 0.1 and 5.4 ± 0.1, and in girls - 6,1 ± 0,11, 5,9 ± 0,05 and 5,7 ±0,13. In boys,  differences between groups on this indicator reached  significant level (р = 0,032). At  same time, systolic and diastolic BP from  first to  third group rose in boys by 9 and 2, and in girls – by 11 and 4 mm Hg.  TC, LDL and TG also increased from  first to  third group in boys by 0.5, 0.4 and 0.5, and in girls - by 0.6, 0.7 and 0.65 mmol/l. HDL decreased in these groups in boys by 0.07, and in girls – by 0.37 mmol/l. Glucose level from  first to  third group increased by 0.12 in boys and 0.14 mmol/l in girls. Conclusion. In contrast to the mature and elderly population,  a decrease in  vascular stiffness  was found among young people as their MT increased.  Moreover, this trend is especially significant among boys  –  difference in this indicator between the extreme groups of girls is 3.5 times less than in boys. Similar data on the improvement of  arterial wall elastic status  in obese children are called by pediatricians "honeymoon" as part of  long-term process of age-related vascular remodeling. It is noteworthy that in young people with an increased BM, positive changes in vascular rigidity occur in the presence of negative changes in hemodynamic and metabolic parameters, which are more significantly represented among girls. Further in-depth research is needed to clarify  mechanisms that regulate relationship between  metabolic status of young people and  peculiarities of their vascular remodeling.

No abstract

Results: 1766 patients were enrolled, and 1423 of them completed the first visit -641 from Ivanovo (mean age 52±9 years, 244 men), and 782 from Saratov (mean age 58 ± 12 years, 449 men). The data of the first visit were used for preliminary analysis. We found no seasonal or intraregional differences in 24-hour pulse wave velocity. At the same time, the values of both 24-hour brachial and aortic augmentation indices were higher in winter (-5.9% ± 2.0% vs. -13.1% ± 2.7%; 27.4% ± 1.3% vs. 22.5% ± 1.7%, respectively, p < 0.05). Conclusions:Despite some limitations of preliminary analyses, our results show the decrease of 24-hour arterial stiffness associated with higher temperature. 24hour oscillometric monitoring seems to be a promising method of arterial stiffness measurement. Further individual analysis of these data is needed.Objective: For use of indicators of Central aortic pressure (CAP) for the purpose of early diagnosis of preclinical atherosclerosis it is necessary to consider sexual features of the specified parameters. We investigated distinctions of indicators of the Central aortic haemodynamic between young men and girls.Design and method: Overall, 52 students from 19 to 23 years of age (25 boys and 27 girls) were recruited in this study according results of preventive medical exemanation. Investigation includes the BPLab®Vasotens Office device (Petr Telegin, Russia), which has passed quality ESH-2011 test. Waveforms were analyzed using the special automatic Vasotens® algorithm, which allows the calculation of central systolic (SYSao), diastolic (DIAao), mean (MBPao) and puls (PPao) blood pressure, central augmentation index (AIxao), amplification of the pulse pressure (PPA) and ejection duration (ED). We used BPStat software, version 05.00.04 (BPLab) to tabulate all the indices of every office measured wave form automatically. The data are presented as the median (25-75 percentile). An alpha level of 5% was considered to be statistically significant. The study was approved by the local ethics committee.

The main role in atherosclerotic damage of the vascular wall is given now to the inflammatory process, the development of which is facilitated by a variety of risk factors (RF). Many of these factors begin to affect on the cardiovascular (CV) system in youth and even in childhood. Some authors refer to RF infectious-inflammatory diseases (IID), which were transferred earlier. The aim is to evaluate some parameters of vascular status in young people in the presence of such focal infection (FI) as chronic decompensated tonsillitis (CDT). Material and methods. Within the main group, 52 young patients aimed at performing surgery due to the presence of IID (age from 18 to 27 years) were examined. 76 persons of comparable sex, age and profile of the main RF without any IID were served as control. The control group was formed from the number of students according to the results of the annual preventive examination in the framework of the Federal Program "University of healthy lifestyle". Both groups were quite comparable in age, sex and profile of the main RF. In addition to the assessment RF-profile it was carried out the determination of indicators of the central pressure and vascular stiffness with the help of hardware-diagnostic complex BPLab ("Petr Telegin", Nizhny-Novgorod, Russia) with the use of programs set Vasotens Office. This program involves an in-depth contour analysis of the properties of pulse waves at the level of both the aorta and peripheral arteries. Statistical processing was carried out using the software "Statistica 10.0" (StatSoft Inc, USA). Results: It was found that in the main group compared with the control group, the pulse wave propagation velocity in the aorta PWVao equal to 10.61±0.25 versus 9.73±0.15 m/s (p=0.004), the augmentation index in the aorta AIxao was 3.88±0.31 versus -1.04±0.08%. In discussing two groups augmentation index in the brachial artery AIx made up of 32.15±2,70 against -48,89±1,52% (p=0.05), arterial augmentation index, AIx normalized to heart rate heart rate was equal to -35,23±vs -49,67 of 5.39±2.56%. In this case, the values of both peripheral and aortic SBP, DBP, Medium BP and Puls BP in patients with DHT were slightly lower than in persons of the control group. Conclusion: The data of the youth study of the dense-elastic vascular potential in different parts of the arterial bed showed a marked increase in vascular rigidity from both the peripheral arteries and the aorta in presence of CDT. In this case, aortic remodeling was more pronounced. It is useful to consider these findings in process of planning and implementing individualized prevention programmes among young people, taking into account the availability of FI.