Abstract P168: Vascular Stiffness in Young Men Subject to Presence of Chronic Decompensated Tonsillitis

Abstract

The main role in atherosclerotic damage of the vascular wall is given now to the inflammatory process, the development of which is facilitated by a variety of risk factors (RF). Many of these factors begin to affect on the cardiovascular (CV) system in youth and even in childhood. Some authors refer to RF infectious-inflammatory diseases (IID), which were transferred earlier. The aim is to evaluate some parameters of vascular status in young people in the presence of such focal infection (FI) as chronic decompensated tonsillitis (CDT). Material and methods. Within the main group, 52 young patients aimed at performing surgery due to the presence of IID (age from 18 to 27 years) were examined. 76 persons of comparable sex, age and profile of the main RF without any IID were served as control. The control group was formed from the number of students according to the results of the annual preventive examination in the framework of the Federal Program "University of healthy lifestyle". Both groups were quite comparable in age, sex and profile of the main RF. In addition to the assessment RF-profile it was carried out the determination of indicators of the central pressure and vascular stiffness with the help of hardware-diagnostic complex BPLab ("Petr Telegin", Nizhny-Novgorod, Russia) with the use of programs set Vasotens Office. This program involves an in-depth contour analysis of the properties of pulse waves at the level of both the aorta and peripheral arteries. Statistical processing was carried out using the software "Statistica 10.0" (StatSoft Inc, USA). Results: It was found that in the main group compared with the control group, the pulse wave propagation velocity in the aorta PWVao equal to 10.61±0.25 versus 9.73±0.15 m/s (p=0.004), the augmentation index in the aorta AIxao was 3.88±0.31 versus -1.04±0.08%. In discussing two groups augmentation index in the brachial artery AIx made up of 32.15±2,70 against -48,89±1,52% (p=0.05), arterial augmentation index, AIx normalized to heart rate heart rate was equal to -35,23±vs -49,67 of 5.39±2.56%. In this case, the values of both peripheral and aortic SBP, DBP, Medium BP and Puls BP in patients with DHT were slightly lower than in persons of the control group. Conclusion: The data of the youth study of the dense-elastic vascular potential in different parts of the arterial bed showed a marked increase in vascular rigidity from both the peripheral arteries and the aorta in presence of CDT. In this case, aortic remodeling was more pronounced. It is useful to consider these findings in process of planning and implementing individualized prevention programmes among young people, taking into account the availability of FI.

Tonsil problem and its cardiovascular aspects at present stage

“…Среди ИВЗ наиболее полно в обсуждаемом аспекте изучен парадонтит, патогенетическая связь которого с ишемической болезнью сердца (ИБС) расшифрована достаточно полно к настоящему времени [4]. Сведений же о возможном влиянии ХТ на атерогенез до сих пор явно недостаточно [5,6], хотя именно тонзиллит из всех очаговых хронических инфекций (ОХИ) чаще всего встречается среди молодежи по сравнению с другими заболеваниями из числа ОХИ. Сопоставлений вовлеченности сердечной мышцы и сосудистой стенки при ХТ никто еще даже и не пытался выполнить.…”