Influence of chronic kidney disease on hospitalization, chronic dialysis, and mortality in Japanese men: a longitudinal analysis

Nishikawa, Kunihito; Takahashi, Ken; Yamada, Ryoji; Kinaga, Tsuyoshi; Matsumoto, Masato; Yamamoto, Masayuki

doi:10.1007/s10157-016-1293-5

Cited by 15 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several other studies examined the incidence of ESRD stratified by eGFR or albuminuria as well (Tonelli et al 2011;Coresh et al 2014;Wada et al 2014;Tanaka et al 2015). Nishikawa et al (2017) used data from one employer-based insurer, including health checkup and claims data, to investigate the risk of dialysis initiation among male workers in Japan. The incidence according to eGFR level in their study was not different from that found in the current study, except for the rate of the subjects with stage G3b CKD (12.5/1,000 by Nishikawa et al (2017) vs. 2.57/1,000 in the present study); the discrepancy might stem from differences in patient characteristics, such as sex, age, and employment status, as well as the observation periods (2006-2013 vs. 2012-2017).…”

Section: Discussionmentioning

confidence: 99%

“…Nishikawa et al (2017) used data from one employer-based insurer, including health checkup and claims data, to investigate the risk of dialysis initiation among male workers in Japan. The incidence according to eGFR level in their study was not different from that found in the current study, except for the rate of the subjects with stage G3b CKD (12.5/1,000 by Nishikawa et al (2017) vs. 2.57/1,000 in the present study); the discrepancy might stem from differences in patient characteristics, such as sex, age, and employment status, as well as the observation periods (2006-2013 vs. 2012-2017). Smaller sample size may also have caused larger chance errors and resulting discrepancies, especially in the stratified analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Although the Japanese Society of Nephrology and the Japanese Diabetes Society recommend urine quantitative albumin/protein measurements for the classification of the DN staging, quantitative measurements were not included in the health checkup; we instead used urine qualitative exam to distinguish between no overt proteinuria (that can include microalbuminuria that may not be detectable with dipstick urine analysis alone) and overt proteinuria (1+ or greater), as other studies adopted the definition (Hirayama et al 2015;Nishikawa et al 2017).…”

Section: Measurementsmentioning

confidence: 99%

See 2 more Smart Citations

Risk-Stratified Incidence of Renal Replacement Therapy Initiation: A Longitudinal Analysis Using Medical Claims and Health Checkup Data

Sugiyama

Oba

Kobayashi

2019

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Intervention for higher-risk participants of health checkups especially with diabetes has been started in Japan to prevent renal replacement therapy (RRT) initiation, but evidence about RRT initiation risk among checkup participants has been scarce. To estimate the incidence by risk factors, we conducted a retrospective cohort study using medical claims and checkup data of a community-based insurance scheme in Japan. Beneficiaries who participated in the checkup in 2012-2013 were included and followed up for about five years. We estimated the incidence of RRT initiation by the subject characteristics, followed by investigation for risk factors in bivariate analyses and multivariable regression analyses with Bayesian prior probability distributions. As a result, among 49,252 participants, 37 initiated dialysis (0.21/1,000 person-years); no kidney transplantation was performed during the period. Baseline estimated glomerular filtration rate was strongly associated with dialysis initiation. No dialysis was initiated among those without baseline hypertension; cumulative incidence by hypertension status was significantly different (p < 0.001). Diabetes was significantly associated with dialysis initiation in bivariate analysis, but the association was not significant in multivariable regression analysis [reference: no diabetes; incidence rate ratio (IRR) for diabetes without medication, 3.30 (95% credible interval, 0.48-15.56); IRR for diabetes with medication, 1.69 (95% credible interval, 0.68-3.47)]. In conclusion, potential risk factors for RRT initiation include male sex, comorbid hypertension, and current smoking status, in addition to advanced chronic kidney disease, proteinuria, and diabetes. New initiatives should consider these factors to increase the efficacy of the programs at the population level.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Risk-Stratified Incidence of Renal Replacement Therapy Initiation: A Longitudinal Analysis Using Medical Claims and Health Checkup Data

Sugiyama

Oba

Kobayashi

2019

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…In another study, all-cause hospitalization increased with CKD stage [ 16 ]. Meanwhile, Japanese medical checkup data have shown that a lower estimated glomerular filtration rate (eGFR) is associated with increased risk of all-cause hospitalization and CVD death [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study

et al. 2019

View full text Add to dashboard Cite

Background Chronic kidney disease is a known risk factor for end-stage renal and cardiovascular diseases. However, data are limited on the causes of hospitalization in patients with chronic kidney disease of maintenance period. This study aimed to aggregate hospitalization data of CKD patients and to determine the high-risk population. In addition, we compared CKD population to general population. Methods We conducted a post hoc analysis of the chronic kidney disease-Japan cohort study, a multicenter prospective cohort study of 2966 patients with chronic kidney disease with a median 3.9 years of follow-up. We examined the hospitalization reasons and analyzed the risk factors. Results We found 2897 all-cause hospitalization events (252.3 events/1000 person-years), a hospitalization incidence 17.1-fold higher than that in an age- and sex-matched cohort from the general Japanese population. Kidney, eye and adnexa, and heart-related hospital admissions were the most common. All-cause hospitalization increased with chronic kidney disease stage and with the presence of diabetes. Patients with diabetes at enrollment had 345.7 hospitalization events/1000 person-years, which is considerably higher than 196.8 events/1000 person-years for those without diabetes. Survival analysis, using hospitalization as an event, showed earlier all-cause hospitalization with the progression of chronic kidney disease stage and diabetes. Cardiovascular disease hospitalizations were more strongly influenced by diabetes than chronic kidney disease stage. Conclusions Patients with chronic kidney disease and diabetes are highly vulnerable to hospitalization for a variety of diseases. These descriptive data can be valuable in predicting the prognosis of patients with chronic kidney disease. Electronic supplementary material The online version of this article (10.1007/s10157-019-01730-9) contains supplementary material, which is available to authorized users.

show abstract

“…Medical and dental fee receipts were sent monthly to the KSHIA by the hospitals that insured employees consulted, as shown in our previous study. 31 We followed all receipts from January 2010 to December 2013. Receipts were divided into the following four categories: medical inpatient, medical outpatient, dental inpatient, and dental outpatient.…”

Section: Follow-up and Endpointsmentioning

confidence: 99%

Combined Associations of Body Mass Index and Metabolic Health Status on Medical and Dental Care Days and Costs in Japanese Male Employees: A 4-Year Follow-Up Study

Nishikawa

Yamamoto

2020

Journal of Epidemiology

Self Cite

View full text Add to dashboard Cite

Background: The combined associations of body mass index (BMI) levels and metabolic dysfunction with medical and dental care utilizations is unclear. Methods: A 4-year follow-up study was performed in 16,386 Japanese male employees (mean age 48.2 [standard deviation, 11.0] years) without a history of cardiovascular disease (CVD), cancer, or renal failure. They were classified into eight phenotypes based on four BMI levels (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; and obese, ≥30.0 kg=m 2) and the presence or absence of ≥2 of 4 metabolic abnormalities: high blood pressure, high triglycerides, low highdensity-lipoprotein cholesterol, and high blood sugar. Based on their health insurance claims data, we compared medical and dental care days and costs among the eight different BMI=metabolic phenotypes during 2010-2013. Results: The combinations of BMI levels and metabolic status were significantly associated with the adjusted mean and median medical outpatient days and costs and the median dental outpatient days and costs. The obese=unhealthy subjects had the highest medical outpatient days and costs, and the underweight=unhealthy subjects had the highest dental outpatient days and costs. The underweight=unhealthy subjects also had the highest medical inpatient days and hospitalization rates of CVD, and had higher medical costs compared with the obese=healthy subjects. The differences in median medical costs between healthy and unhealthy phenotypes were larger year by year across all BMI levels. Conclusions: Identification of obesity phenotypes using both BMI levels (including the underweight level) and metabolic status may more precisely predict healthcare days and costs compared with either BMI or metabolic status alone.

show abstract

Influence of chronic kidney disease on hospitalization, chronic dialysis, and mortality in Japanese men: a longitudinal analysis

Abstract: In Japanese men, although the risk of CVD death before dialysis initiation can never be ignored, CKD patients aged <60 years with a GFR of <30 mL/min/1.73 m are more likely to undergo dialysis prior to death.

Cited by 15 publications

References 26 publications

Risk-Stratified Incidence of Renal Replacement Therapy Initiation: A Longitudinal Analysis Using Medical Claims and Health Checkup Data

Risk-Stratified Incidence of Renal Replacement Therapy Initiation: A Longitudinal Analysis Using Medical Claims and Health Checkup Data

Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study

Combined Associations of Body Mass Index and Metabolic Health Status on Medical and Dental Care Days and Costs in Japanese Male Employees: A 4-Year Follow-Up Study

Contact Info

Product

Resources

About