Influence of combined exposure levels of total arsenic and inorganic arsenic on arsenic methylation capacity among university students: findings from Bayesian kernel machine regression analysis

Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water

“…Use of the lower level for iAs exposure in the current research is germane to simulating exposures that occur in many populations worldwide that use iAs-contaminated water sources. Comparison of iAs metabolism at low and high exposure levels is particularly relevant, as it has been suggested that a high iAs exposure may result in saturation of the pathway for iAs methylation in humans, resulting in higher %iAs and %MAs, or lower %DMAs in urine 42 – 46 . Although this effect has not been observed in WT mice 14 , it was plausible to assume that saturation may occur in Hs mice, in which the low efficiency of iAs methylation resembles that in humans 18 .…”

Atomic spectrometry update: review of advances in elemental speciation

“…The study concluded that due to the correlations and differences in As species distribution between urine and blood, each medium may have different role as an As biomarker. Arsenic methylation capacity has also been studied by Jiang et al 57 These workers measured urinary concentrations of iAs, MMA, and DMA using HPLC-HG-AFS and calculated the primary methylation capacity index and secondary methylation capacity index in 209 university students in Hefei, China, a non-As endemic area. Volunteers were given a standardised questionnaire asking about their sociodemographic characteristics.…”

“…LC-MS/MS but are rarely quantied and this latter aspect has been addressed in a comprehensive paper from researchers in Pau. 81 In this work coconut water was spiked with Fe enriched with either 57 Fe or 58 Fe which was allowed to equilibrate with the naturally occurring citrate and malate ligands present in the sample for 12 hours. Subsequently, the spiked sample was diluted and separated on a HILIC column (150 × 2.1 mm, 2.6 mm Ø) with a gradient elution using 5 mmol L −1 ammonium acetate in water and 5 mmol L −1 ammonium acetate in 95% acetonitrile, each at a pH of 5.5, owing at 0.5 mL min −1 for 23 minutes.…”