Influence of Common Cardiac Drugs on Gastroesophageal Reflux Disease: Multicenter Questionnaire Survey

Nakaji, Gen; Yousuke, Kogawa; Nakamura, Hisataka; Fujihara, Masahiko; Fukata, Mitsuhiro; Yasuda, Shin; Odashiro, Keita; Maruyama, Toru; Akashi, Koichi

doi:10.4020/jhrs.27.pj1_032

Cited by 12 publications

(14 citation statements)

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“…The score was found to be high in patients taking CCBs (OR: 3.19, 95% CI 1.01-10.11, p<0.049). In addition,than in those who only received acid-suppressive therapy (25). In a retrospective study involving 371 patients who used CCBs because of non-cardiac chest pain, 130 of the patients had gastrointestinal symptoms (heartburn) prior to CCB treatment; symptom exacerbation was detected in 45.4% of these patients, and 241 (35.3%) of the patients developed new reflux symptoms.…”

Section: Nitrates and Calcium Channel Blockersmentioning

confidence: 99%

Which drugs are risk factors for the development of gastroesophageal reflux disease?

Mungan

Simsek

2020

Turk J Gastroenterol

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Section: Nitrates and Calcium Channel Blockersmentioning

confidence: 99%

Which drugs are risk factors for the development of gastroesophageal reflux disease?

Mungan

Simsek

2020

Turk J Gastroenterol

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“…It has been proven that common cardiac drugs used to treat CAD, particularly nitrates, calcium-channel blockers and antiplatelet drugs, may either predispose patients to GERD or aggravate preexisting GERD (7)(8)(9). However, we are the first to find that the combined use of common cardiac drugs, especially CCB combined with antiplatelets (p=0.014) and the combination of CCB, antiplatelets and nitrates (p=0.034), may predispose or aggravate GERD.…”

Section: Mehta Et Al Investigated Only 24 Patients (24)mentioning

confidence: 80%

“…As a matter of fact, among patients with CAD experiencing chest pain, 50% have gastroesophageal reflux disease (GERD) (6). Furthermore, the most common cardiac drugs used to treat CAD, particularly nitrates, calcium-channel blockers (CCBs) and antiplatelet drugs, may either predispose CAD patients to GERD or aggravate preexisting GERD (7)(8)(9); hence, escalating treatment can increase chest pain, leading the physician to the erroneous conclusion that the CAD is worsening. Previous studies have provided support for the use of acid suppression with proton pump inhibitors in patients with CAD to decrease pain symptoms and improve the general health-related quality of life (HRQL) (10,11).…”

Section: Introductionmentioning

confidence: 99%

Acid Reflux in Patients with Coronary Artery Disease and Refractory Chest Pain

Liu

Chen

et al. 2013

Intern. Med.

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Objective To investigate the influence of acid reflux on chest pain and ischemic events and the effects of cardiac drugs on acid reflux in patients with coronary artery disease (CAD) and refractory chest pain. Methods Simultaneous 24-hour esophageal pH monitoring and 24-hour continuous electrocardiogram (ECG) (Holter) results were obtained for 64 patients. Ischemic events and cardiac drug prescriptions were compared between the patients with and without gastroesophageal reflux disease (GERD). Patients fulfilling the GERD criteria received 14-day therapy with omeprazole at a dose of 20 mg bid. The results of the 24-hour pH monitoring, Holter and the SF-36 questionnaire were compared before treatment and again after two weeks of therapy. Results GERD was identified in 38 (69%) patients, with 49% of all chest pain occurring in association with acid reflux. A higher incidence (p=0.033) and longer duration (p=0.040) of ischemic events were observed in the GERD (+) patients. More frequent combined use of cardiac drugs was found in the GERD (+) patients. However, fewer ischemic events and greater total SF-36 survey scores were noted after PPI therapy in the GERD (+) patients. Conclusion Acid reflux is common in patients with CAD and refractory chest pain. Refractory chest pain in patients with CAD can be partially noncardiac chest pain (NCCP) secondary to acid reflux. The combined use of common cardiac drugs may predispose or aggravate GERD. Short-term proton pump inhibitor (PPI) therapy not only restores a normal esophageal pH, but also significantly improves the general health-related quality of life (HRQL) of patients.

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“…CCBs allowing for lower esophageal sphincter relaxation were prescribed in 22.1% of the subjects, and warfarin was prescribed in the AF patients. These two agents are prone to aggravating symptomatic GERD, based on the findings of our recent study (39). PPIs were prescribed in 84 patients at the outpatient clinics (41.8%).…”

Section: Limitationsmentioning

confidence: 99%

Further Assessment of Atrial Fibrillation as a Risk Factor for Gastroesophageal Reflux Disease: A Multicenter Questionnaire Survey

et al. 2013

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Objective Although both atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are common diseases, the relationship between these two conditions remains controversial, depending on the study design and type of AF. Therefore, we focused on the relationship between nonvalvular AF and GERD. Methods A total of 479 consecutive subjects (255 men and 224 women, mean age: 60.4 ± 12.8 years), including outpatients at several hospitals (n=201) and participants of an annual health screening program (n= 278), were enrolled. Subjects with valvular AF, malignancy or dementia were excluded. The frequency scale for symptoms of GERD (F-scale) was applied after obtaining each patient's informed consent for screening symptomatic GERD with a total cutoff score of 8 points. The score on the questionnaire was correlated with the baseline characteristics extracted from the patients' medical records. Results The total F-scale scores were significantly higher in the older patients (! 60 years) than in the younger patients (<60 years) (p=0.017) and increased in the following order: permanent AF > paroxysmal AF > sinus rhythm (p=0.003). The incidence of GERD increased in the same order among the patients with the various heart rhythm classifications (p<0.001). Coronary heart disease, hypertension, diabetes and dyslipidemia were not correlated with the F-scale scores or incidence of GERD. The stepwise discriminant analyses demonstrated that nonvalvular AF alone was significantly associated with symptomatic GERD (Wilks' lambda=0.983, p=0.004). Conclusion This multicenter study demonstrated that nonvalvular AF is significantly correlated with symptomatic GERD. This small sample survey warrants a future study of a large-scale cohort.

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Influence of Common Cardiac Drugs on Gastroesophageal Reflux Disease: Multicenter Questionnaire Survey

Cited by 12 publications

References 0 publications

Which drugs are risk factors for the development of gastroesophageal reflux disease?

Which drugs are risk factors for the development of gastroesophageal reflux disease?

Acid Reflux in Patients with Coronary Artery Disease and Refractory Chest Pain

Further Assessment of Atrial Fibrillation as a Risk Factor for Gastroesophageal Reflux Disease: A Multicenter Questionnaire Survey

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