Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits

Abstract

The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel ® PH 101 and Avicel ® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel ® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH).Keywords: Cornus mas, microcrystalline cellulose, direct compression, accelerated stability, principal component analysis Lifestyle diseases such as cancer, cardiovascular diseases or diabetes mellitus type 2 are gradually becoming the global centre of attention as both direct and indirect economic costs increase each year. Therefore, new approaches to preventing the onset and progression of these diseases are being implemented. Antioxidants represent a promising supplement group with proven positive effects in the prevention of lifestyle diseases (1). Less commonly used plants and herbal remedies are becoming more and more popular sources of such antioxidants (2).One of the most promising medicinal plants with a broad spectrum of antioxidants is Cornelian cherry (Cornus mas) whose medicinal effect has been known for years (3). Its antibacterial, astringent, antidiarrheal and hypolipidemic effect have been already studied (4-6). Moreover, the antidiabetic effect of Cornelian cherry, based on its antioxidant properties, has become a target of recent scientific studies (7). For these reasons, efforts have been made to process Cornelian cherry fruits into tablets without using extraction methods. A previously published work describes the main constituent substances and pharmacological effects of Cornelian cherry fruits and points to the ALEŠ FRANC 1

Evaluation and Comparison of Three Types of Spray Dried Coprocessed Excipient Avicel® for Direct Compression

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Structural Changes of Sodium Warfarin in Tablets Affecting the Dissolution Profiles and Potential Safety of Generic Substitution

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