This paper demonstrates the effects of hot isostatic pressure (HIP) on the structure and transport critical parameters of in situ MgB 2 wires without a barrier. Our results show that only HIP and nano-boron allow the formation of more high-field pinning centers, which lead to the increase in critical current density (J c ) at high applied magnetic fields. Nano-boron and annealing at a low pressure increase the J c in the low magnetic field. This indicates that nano-particles create more high-field pinning centers. In addition, the results show that nano-boron improves the connection between the grains. Scanning electron microscope results show that HIP increases the reaction rate between Mg and B, density, and homogeneity of the MgB 2 material. Additionally, HIP allows to create a structure with small grains and voids and eliminates the significance of the number of voids. High isostatic pressure allows to obtain high J c of 10 A/mm 2 (at 4.2 K) in 10 T and increases irreversible magnetic field (B irr ) and upper critical field (B c2 Measurements show that these wires have high critical temperature of 37 K.