Influence of cycloartanes from plants of the genusAstragalus and their synthetic analogs on the contractive function of the myocardium and the activity of Na,K-ATPase

Хушбактова, З. А.; Агзамова, М. А.; Сыров, В. Н.; Radchenko, N. V.; Mirsalikhova, N. M.; Umarova, F T

doi:10.1007/bf00630402

Cited by 4 publications

(2 citation statements)

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“…Astragalus roots are known to be rich in two major classes of biologically active compounds, polysaccharides and saponins (Rios and Waterman, 1997;Bedir et al, 2000a). Astragalus saponins have shown interesting pharmacological properties, including immunostimulation (Calis et al, 1997;Bedir et al, 2000a;Yeş ilada et al, 2005), anti-protozoal (Özipek et al, 2005), antiviral (Özipek et al, 2005), cytotoxic (Radwan et al, 2004) and cardiotonic activities (Khushbaktova et al, 1994;Luo et al, 2004;Chan et al, 2009). Moreover, Astragaloside IV, a widely encountered cycloartane-type saponin found in Astragalus species, has been proven to be a neuroprotective agent and proposed as a potential agent in the treatment of Parkinson's disease (Luo et al, 2004;Chan et al, 2009).…”

Section: Introductionmentioning

confidence: 97%

Adjuvant effects of Astragalus saponins Macrophyllosaponin B and Astragaloside VII

Nalbantsoy

Nesil

Erden

et al. 2011

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 97%

Adjuvant effects of Astragalus saponins Macrophyllosaponin B and Astragaloside VII

Nalbantsoy

Nesil

Erden

et al. 2011

Journal of Ethnopharmacology

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“…have hypocholesterolemic activity [8] [9], contributing to the normalization of lipid metabolism and improving cardiac activity. The activity of glycosides-Cyclosiversioside A and Cycloorbicoside G on metabolic processes in rat myocardium was revealed [10] [11]. Cycloartane glycosides isolated from Astragalus orbiculatus showed an interferon inducing effect [12], cytotoxic activity [13].…”

Section: Introductionmentioning

confidence: 99%

The Anatomical Structure of Leaves and Thorns Plants <i>Astragalus pterocephalus</i> Bunge, Growing in Uzbekistan

Agzamova¹,

Duschanova²,

Rakhmatov³

et al. 2020

AJPS

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The results of a study conducted by light microscopy of the anatomical structure of the leaf and thorns of Astragalus pterocephalus growing in the natural habitat of the Amankutan Mountains of the Samarkand region (Uzbekistan) are presented. The following diagnostic features were identified: leaf-isolateral-palisade type of mesophyll leaf; thick-walled outer walls of the epidermis; the outline of epidermal cells is rectilinear, the projection is polygonal; amphystomatic leaves; submerged numerous stomata of hemiparacitic and anomocytic type; chlorophyll-bearing palisade and spongy parenchyma; closed collateral type of vascular bundles and more sclerified, due to sclerenchymal cells. Thorn-parenchymal-beam type of structure; thin-walled outer walls of the epidermis; under the epidermis is a lamellar collenchyma; closed collateral type of vascular bundles and more sclerified, due to sclerenchymal cells. The complex of the above features reflects the species specificity of the structure of the leaf and spines. Identified and described features that can be used in the taxonomy of the studied tribes and can serve to identify plant materials.

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Potent telomerase activators from a novel sapogenin via biotransformation utilizing Camarosporium laburnicola, an endophytic fungus

et al. 2023

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Background Cycloartane-type triterpenoids possess important biological activities, including immunostimulant, wound healing, and telomerase activation. Biotransformation is one of the derivatization strategies of natural products to improve their bioactivities. Endophytic fungi have attracted attention in biotransformation studies because of their ability to perform modifications in complex structures with a high degree of stereospecificity. Results This study focuses on biotransformation studies on cyclocephagenol (1), a novel cycloartane-type sapogenin from Astragalus species, and its 12-hydroxy derivatives (2 and 3) to obtain new telomerase activators. Since the hTERT protein levels of cyclocephagenol (1) and its 12-hydroxy derivatives (2 and 3) on HEKn cells were found to be notable, biotransformation studies were carried out on cyclocephagenol and its 12-hydroxy derivatives using Camarosporium laburnicola, an endophytic fungus isolated from Astragalus angustifolius. Later, immunoblotting and PCR-based ELISA assay were used to screen starting compounds and biotransformation products for their effects on hTERT protein levels and telomerase activation. All compounds showed improved telomerase activation compared to the control group. Conclusions As a result of biotransformation studies, seven new metabolites were obtained and characterized, verifying the potential of C. laburnicola as a biocatalyst. Additionally, the bioactivity results showed that this endophytic biocatalyst is unique in transforming the metabolites of its host to afford potent telomerase activators.

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Influence of cycloartanes from plants of the genusAstragalus and their synthetic analogs on the contractive function of the myocardium and the activity of Na,K-ATPase

Cited by 4 publications

References 2 publications

Adjuvant effects of Astragalus saponins Macrophyllosaponin B and Astragaloside VII

Adjuvant effects of Astragalus saponins Macrophyllosaponin B and Astragaloside VII

The Anatomical Structure of Leaves and Thorns Plants <i>Astragalus pterocephalus</i> Bunge, Growing in Uzbekistan

Potent telomerase activators from a novel sapogenin via biotransformation utilizing Camarosporium laburnicola, an endophytic fungus

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Influence of cycloartanes from plants of the genusAstragalus and their synthetic analogs on the contractive function of the myocardium and the activity of Na,K-ATPase

Cited by 4 publications

References 2 publications

Adjuvant effects of Astragalus saponins Macrophyllosaponin B and Astragaloside VII

Adjuvant effects of Astragalus saponins Macrophyllosaponin B and Astragaloside VII

The Anatomical Structure of Leaves and Thorns Plants &lt;i&gt;Astragalus pterocephalus&lt;/i&gt; Bunge, Growing in Uzbekistan

Potent telomerase activators from a novel sapogenin via biotransformation utilizing Camarosporium laburnicola, an endophytic fungus

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The Anatomical Structure of Leaves and Thorns Plants <i>Astragalus pterocephalus</i> Bunge, Growing in Uzbekistan