Influence of damage to the suprachiasmatic nuclei of the hypothalamus of rats on the dynamics of short-period fluctuations of normal and abnormal behavior

Arushanyan, É. B.; Попов, А. В.

doi:10.1007/bf02360039

Cited by 15 publications

(13 citation statements)

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“…Thus, the authors concluded that SCN lesions have a protective effect in the induction of behavioral despair 88 . Similar conclusions were reached almost a decade earlier when Arushanyan and colleagues demonstrated reduced immobility during the forced swim test, in rats that received bilateral SCN lesions 89 . It may be difficult to draw definitive conclusions from these studies as testing of depressive-like behavior occurred during the inactive phase of the rats.…”

Section: Circadian Rhythm Disruption and Major Depressive Disordersupporting

confidence: 77%

Circadian rhythm disruption and mental health

et al. 2020

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Circadian rhythms are internal manifestations of the solar day that permit adaptations to predictable environmental temporal changes. These~24-h rhythms are controlled by molecular clockworks within the brain that are reset daily to precisely 24 h by exposure to the light-dark cycle. Information from the master clock in the mammalian hypothalamus conveys temporal information to the entire body via humoral and neural communication. A bidirectional relationship exists between mood disorders and circadian rhythms. Mood disorders are often associated with disrupted circadian clock-controlled responses, such as sleep and cortisol secretion, whereas disruption of circadian rhythms via jet lag, night-shift work, or exposure to artificial light at night, can precipitate or exacerbate affective symptoms in susceptible individuals. Evidence suggests strong associations between circadian rhythms and mental health, but only recently have studies begun to discover the direct interactions between the circadian system and mood regulation. This review provides an overview of disrupted circadian rhythms and the relationship to behavioral health and psychiatry. The focus of this review is delineating the role of disruption of circadian rhythms on mood disorders using human night shift studies, as well as jet lag studies to identify links. We also review animal models of disrupted circadian rhythms on affective responses. Lastly, we propose low-cost behavioral and lifestyle changes to improve circadian rhythms and presumably behavioral health.

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Section: Circadian Rhythm Disruption and Major Depressive Disordersupporting

confidence: 77%

Circadian rhythm disruption and mental health

et al. 2020

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“…However, there is only limited evidence that SCNx animals suffer disturbed mood regulation. SCNx rats show less immobility in the forced swim test, but no impact on behavior in the social defeat paradigm (Arushanian & Popov, 1994;Tataroglu, Aksoy, Yilmaz, & Canbeyli, 2004;Tuma, Strubbe, Mocaer, & Koolhaas, 2005).…”

Section: Scnmentioning

confidence: 86%

The role of the circadian clock in animal models of mood disorders.

Landgraf¹,

McCarthy²,

Welsh³

2014

Behavioral Neuroscience

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An association between circadian clock function and mood regulation is well established and has been proposed as a factor in the development of mood disorders. Patients with depression or mania suffer disturbed sleep–wake cycles and altered rhythms in daily activities. Environmentally disrupted circadian rhythms increase the risk of mood disorders in the general population. However, proof that a disturbance of circadian rhythms is causally involved in the development of psychiatric disorders remains elusive. Using clock gene mutants, manipulations of sleep–wake and light–dark cycles, and brain lesions affecting clock function, animal models have been developed to investigate whether circadian rhythm disruptions alter mood. In this review, selected animal models are examined to address the issue of causality between circadian rhythms and affective behavior.

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“…Early studies investigated whether the SCN regulates mood by assessing mood-like behaviors in SCN-lesioned rats. Two groups found that lesioning the SCN resulted in less immobility in the forced swim test [ 236 , 237 ]. One interpretation is that disrupting SCN function has antidepressant effects.…”

Section: Effects Of Scn Manipulations On Mood-like Behaviors In Romentioning

confidence: 99%

Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

2017

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Circadian rhythm disturbances are a common symptom among individuals with mood disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms. The SCN consists of self-sustaining oscillators and receives photic and nonphotic cues, which entrain the SCN to the external environment. In turn, through synaptic and hormonal mechanisms, the SCN can drive and synchronize circadian rhythms in extra-SCN brain regions and peripheral tissues. Thus, genetic or environmental perturbations of SCN rhythms could disrupt brain regions more closely related to mood regulation and cause mood disturbances. Here, we review clinical and preclinical studies that provide evidence both for and against a causal role for the SCN in mood disorders.

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Influence of damage to the suprachiasmatic nuclei of the hypothalamus of rats on the dynamics of short-period fluctuations of normal and abnormal behavior

Cited by 15 publications

References 1 publication

Circadian rhythm disruption and mental health

Circadian rhythm disruption and mental health

The role of the circadian clock in animal models of mood disorders.

Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

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