Influence of degradation on the crystallization behaviour of a biodegradable segmented copolymer constituted by glycolide and trimethylene carbonate units

Díaz-Celorio, Elena; Franco, Lourdes; Rodríguez‐Galán, Alfonso; Puiggalı́, Jordi

doi:10.1016/j.polymdegradstab.2010.08.021

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…19 PTMC exhibits good exibility, and is widely used as a soening component together with other polymers to prepare bioresorbable sutures known as Maxon®, Monosyn® or Bio-syn®. 20,21 On the other hand, PGA is a fast degrading polyester with high strength and low elongation at break. Meanwhile, the GA monomer shows much higher reactivity than the LLA and TMC ones.…”

Section: Introductionmentioning

confidence: 99%

Composites of poly(l-lactide-trimethylene carbonate-glycolide) and surface modified calcium carbonate whiskers as a potential bone substitute material

et al. 2016

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Calcium carbonate whisker (CCW) particles were surface modified by grafting of poly(L-lactide) (PLLA) chains in order to improve their affinity to a poly(L-lactide-trimethylene carbonate-glycolide) (PLTG) terpolymer matrix. Composites of the PLTG matrix with CCW and PLLA-g-CCW of various contents were prepared by mixing in solution followed by solvent evaporation. The structure and properties of pure CCW, surface modified PLLA-g-CCW and PLTG/PLLA-g-CCW composites were investigated using Fourier transfer-infrared spectrometry (FT-IR), mechanical testing, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), contact angle measurement, thermal gravity analysis (TGA) and differential scanning calorimetry (DSC). Data show that PLLA chains were successfully grafted on the CCW surface. The PLTG/PLLA-g-CCW composites exhibit a higher tensile strength and elongation at break than neat PLTG. Optimal values are obtained with a PLLA-g-CCW content of 2 wt%. It is assumed that PLLA-g-CCW particles present both reinforcing and toughening effects on the PLTG matrix. The cytocompatibility of the materials was evaluated from cell morphology and MTT assay using the L929 mouse fibroblast cell line. The results indicate that the composite presents very low cytotoxicity. Therefore, PLTG/PLLA-g-CCW composites with improved mechanical properties and good cytocompatibility could be promising as a potential bone substitute material.

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Section: Introductionmentioning

confidence: 99%

Composites of poly(l-lactide-trimethylene carbonate-glycolide) and surface modified calcium carbonate whiskers as a potential bone substitute material

et al. 2016

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“…The hydrolytic degradation of Maxon has been extensively studied, revealing a three‐stage mechanism . In the initial stage (inactive period), the polymer shows minimal water hydration and mass loss.…”

Section: Introductionmentioning

confidence: 99%

Manipulation of the drug‐release behavior of poly(glycolide‐co‐trimethylene carbonate)

Nochos

Andrikopoulos

Voyiatzis

2016

J of Applied Polymer Sci

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The current work focuses on Maxon, a modern biocompatible/bioabsorbable polymer, utilized in the fabrication of surgical sutures, and attempts to explore the limits of controlling the administration rate of a properly incorporated model drug, mitoxandrone dihydrochloride. The control is attempted by tailoring both the structural properties of the host polymer, more specifically its crystallinity and anisotropy, and the level of drug dispersion achieved after following different incorporation methods such as melt and dissolution mixing. The results, based on optical and electron microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy, and UV–vis spectroscopy, indicate that the structural parameters invoked may enable fine‐tuning of the drug dose released within a 60‐day period. Additionally, the burst effect of the active agent at the early stages of release is regulated by adjusting the drug dispersion level. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43915.

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Synthetic biodegradable medical polyesters

Dobrzyński¹,

Kasperczyk²,

Li³

2017

Science and Principles of Biodegradable and Bioresorbable Medical Polymers

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Influence of degradation on the crystallization behaviour of a biodegradable segmented copolymer constituted by glycolide and trimethylene carbonate units

Cited by 7 publications

References 28 publications

Composites of poly(l-lactide-trimethylene carbonate-glycolide) and surface modified calcium carbonate whiskers as a potential bone substitute material

Composites of poly(l-lactide-trimethylene carbonate-glycolide) and surface modified calcium carbonate whiskers as a potential bone substitute material

Manipulation of the drug‐release behavior of poly(glycolide‐co‐trimethylene carbonate)

Synthetic biodegradable medical polyesters

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