Synthetic biodegradable medical polyesters

Dobrzyński, P.; Kasperczyk, Janusz; Li, S.

doi:10.1016/b978-0-08-100372-5.00004-0

Cited by 5 publications

(3 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presented microspheres were obtained from poly (L-lactide/glycolide/trimethylene carbonate), which has many advantages in pharmaceutical and biomedical applications. The terpolymer has been synthesized by using zirconium (IV) acetylacetonate [Zr(acac)4] which served as a non-toxic initiator of ROP (ring-opening polymerization) [ 37 , 38 , 39 ] to provide high biocompatibility. Generally, copolymerization has been broadly used to obtain desired properties in the final materials [ 40 , 41 ] and terpolymers possess even greater potential to tailor properties of the final material compared to copolymers.…”

Section: Discussionmentioning

confidence: 99%

Controlled Release of Encapsuled Stromal-Derived Factor 1α Improves Bone Marrow Mesenchymal Stromal Cells Migration

et al. 2022

View full text Add to dashboard Cite

Stem cell treatment is a promising method of therapy for the group of patients whose conventional options for treatment have been limited or rejected. Stem cells have the potential to repair, replace, restore and regenerate cells. Moreover, their proliferation level is high. Owing to these features, they can be used in the treatment of numerous diseases, such as cancer, lung diseases or ischemic heart diseases. In recent years, stem cell therapy has greatly developed, shedding light on stromal-derived factor 1α (SDF-1α). SDF-1α is a mobilizing chemokine for application of endogenous stem cells to injury sites. Unfortunately, SDF-1α presented short-term results in stem cell treatment trials. Considering the tremendous benefits of this therapy, we developed biodegradable polymeric microspheres for the release of SDF-1α in a controlled and long-lasting manner. The microspheres were designed from poly(L-lactide/glycolide/trimethylene carbonate) (PLA/GA/TMC). The effect of controlled release of SDF-1α from microspheres was investigated on the migration level of bone marrow Mesenchymal Stromal Cells (bmMSCs) derived from a pig. The study showed that SDF-1α, released from the microspheres, is more efficient at attracting bmMSCs than SDF-1α alone. This may enable the controlled delivery of selected and labeled MSCs to the destination in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Controlled Release of Encapsuled Stromal-Derived Factor 1α Improves Bone Marrow Mesenchymal Stromal Cells Migration

et al. 2022

View full text Add to dashboard Cite

show abstract

“…30,31 It is a rubbery material at room temperature, and has been used as a softening component in biodegradable copolymer sutures such as Maxon ® and Biosyn ® . 32 PTMC could act as a hydrophobic segment of diblock copolymers. 33 Therefore, PTMC based micelles are a considerable drug delivery system for PTX loading.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, PTMC degrades in vivo by a surface erosion process, without the formation of acidic degradation products 30,31 . It is a rubbery material at room temperature, and has been used as a softening component in biodegradable copolymer sutures such as Maxon® and Biosyn® 32 . PTMC could act as a hydrophobic segment of diblock copolymers 33 .…”

Section: Introductionmentioning

confidence: 99%

Poly(trimethylene carbonate)‐b‐poly(ethylene glycol) diblock copolymer micelles for hydrophobic drug delivery: The effect of hydrophilic/hydrophobic segment length on micellar properties and drug loading

Sun

Pan

et al. 2022

Polymers for Advanced Techs

View full text Add to dashboard Cite

The encapsulation and release of hydrophobic drugs from polymersomes are of great importance in drug delivery. A significant challenge is to enhance the encapsulation capacity of finding better drug‐polymer compatibility. Herrin, poly(trimethylene carbonate)‐b‐poly(ethylene glycol) (PTMC‐PEG) diblock copolymers were successfully synthesized by ring opening polymerization of trimethylene carbonate using monomethoxy poly(ethylene glycol) (mPEG) as macro‐initiator and stannous octoate as catalyst. The resulting diblock copolymer were characterized by 1H NMR, FTIR, GPC, and DSC techniques. Blank and paclitaxel (PTX) loaded micelles was prepared by co‐solvent evaporation method and characterized by transmission electron microscope (TEM) and dynamic light scattering (DLS). The influence of hydrophilic/hydrophobic segment length to drug loading and release was explored. All micelles have the sustained hydrophobic drug release properties of the micelles. Moreover, the cytotoxicity of micelles was evaluated by MTT and live‐dead cell staining assay using L929 cell lines, showing the good biocompatibility. Therefore, PTMC‐PEG micelles could be a suitable material for the loading and releasing of hydrophobic drugs.

show abstract

Poly(lactide-co-trimethylene carbonate) coatings with ciprofloxacin, fusidic acid and azithromycin. The effect of the drug on the degradation and biological activity against different Staphylococcus reference strains

Jaworska

Jelonek

Wąsik

et al. 2021

European Polymer Journal

View full text Add to dashboard Cite

Synthetic biodegradable medical polyesters

Cited by 5 publications

References 168 publications

Controlled Release of Encapsuled Stromal-Derived Factor 1α Improves Bone Marrow Mesenchymal Stromal Cells Migration

Controlled Release of Encapsuled Stromal-Derived Factor 1α Improves Bone Marrow Mesenchymal Stromal Cells Migration

Poly(trimethylene carbonate)‐b‐poly(ethylene glycol) diblock copolymer micelles for hydrophobic drug delivery: The effect of hydrophilic/hydrophobic segment length on micellar properties and drug loading

Poly(lactide-co-trimethylene carbonate) coatings with ciprofloxacin, fusidic acid and azithromycin. The effect of the drug on the degradation and biological activity against different Staphylococcus reference strains

Contact Info

Product

Resources

About