2022
DOI: 10.14715/cmb/2022.68.2.17
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Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Abstract: The study aimed to explore the influence of Dexmedetomidine (Dex) on cognitive function and inflammatory factors in rats after cardiac surgery under cardiopulmonary bypass (CPB). For this purpose, 30 healthy male SD rats were reared in a quiet and clean environment with alternating light for 12 hours. They were rolled randomly into 3 groups, each with 10 rats, namely the control (Ctrl) group, the experimental group, and the Dex group. The rats in the Ctrl were not treated, and the rats in the experimental grou… Show more

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Cited by 7 publications
(2 citation statements)
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“…In contrast, 16α-OHE1 exerted anti-in ammatory effects by enhancing TGF-β and Arg-1 while reducing TNF-α and iNOS mRNA expression. In addition, the decrease of IL-6, IL-1β, and TNF-α in the myocardium of rats in the 16α-OHE1 dosing group further demonstrated the anti-in ammatory effect of 16α-OHE1, as described in the literature [43,44] . In conclusion, 16α-OHE1 can inhibit hypoxia-induced myocardial in ammatory in ltration.…”
Section: Discussionsupporting
confidence: 69%
“…In contrast, 16α-OHE1 exerted anti-in ammatory effects by enhancing TGF-β and Arg-1 while reducing TNF-α and iNOS mRNA expression. In addition, the decrease of IL-6, IL-1β, and TNF-α in the myocardium of rats in the 16α-OHE1 dosing group further demonstrated the anti-in ammatory effect of 16α-OHE1, as described in the literature [43,44] . In conclusion, 16α-OHE1 can inhibit hypoxia-induced myocardial in ammatory in ltration.…”
Section: Discussionsupporting
confidence: 69%
“…Postoperative cognitive function (POCD) is common in elderly stroke patients and manifests as cognitive decline in various aspects such as memory, language, understanding, thinking or attention [1]. Existing studies have proven that risk factors such as older age, low education level, and preoperative mental health can promote the occurrence of POCD [2]. Evidence from clinical research indicates that POCD may increase mortality, negatively impact quality of life, and require longer hospital stays [3].…”
Section: Introductionmentioning
confidence: 99%