Influence of diet and dietary nanoparticles on gut dysbiosis

Jiang, Ziyu; Jacob, Joe Antony; Jian-yue, LI; Wu, Xiahui; Wei, Guoli; Arunprasanna, Vimalanathan; Mani, Rajesh; Nainangu, Prasannabalaji; Rajadurai, Uma Maheshwari; Chen, Baoan

doi:10.1016/j.micpath.2018.03.017

Cited by 13 publications

(6 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of nanomaterials in food on gut bacteria have drawn considerable attention. 3 , 109 , 110 , 111 , 112 The interaction between nanoparticles and bacteria in the colon may result in viability changes, and consequently, alter relative compositions of bacterial species. Since gut bacteria play a critical role in maintaining human health, 113 nanoparticles in food could result in adverse health effects through changes in the gut microbiota.…”

Section: Main Textmentioning

confidence: 99%

Endogenous Fluorescence Carbon Dots Derived from Food Items

Wang

Tan

2020

The Innovation

View full text Add to dashboard Cite

BACKGROUNDFluorescent carbon dots (CDs) are a novel class of carbon-based nanomaterials that were discovered in 2004. However, nobody knew that CDs existed in food items naturally until 2012. Properties of nanosize materials are distinct from those of their bulk materials due to the particle size and accordingly alter their bioavailability and/or biocompatibility. Therefore, the potential health risk of nanoparticles in food has drawn massive attention. Currently, almost all studies regarding the biosafety of nanoparticles in food have mainly focused on engineered nanoparticles used as food additives and have excluded the endogenous nanoparticles in food. Therefore, investigation of the properties of food-borne fluorescent CDs and their potential health risk to humans is of great significance.

show abstract

Section: Main Textmentioning

confidence: 99%

Endogenous Fluorescence Carbon Dots Derived from Food Items

Wang

Tan

2020

The Innovation

View full text Add to dashboard Cite

show abstract

“…Fecal microbes including Bacteroides such as Alistipes , Prevotella , Firmicutes such as Clostridium, Parvimonas , Peptostreptococcus , Roseburia , and Oscillibacter , Proteobacteria such as Campylobacter , Escherichia , Halomonas , and Shewanella , Verrucomicrobia, Fusobacteria, and Actinobacteria constitute the dysbiosis-associated microbial signatures for CRC. It is interesting to note that Fusobacterium , Parvimonas , Gemella , and Leptotrichia are early bacterial markers for CRC, whereas, β-proteobacteria is a late-stage CRC marker. − Proteins such as human neutrophil peptides, S100 proteins, hemoglobin, haptoglobin, AAT, lactoferrin, CEA, exopeptidases (dipeptidyl peptidases I and IV), cadherin-17, selenium binding protein 1, tumor pyruvate kinase type M2, and MMP-9 are biomarkers of the stool . The list of proteomic, genomic, and microbial biomarkers is shown in Table .…”

Section: Resultsmentioning

confidence: 99%

“…It is interesting to note that Fusobacterium , Parvimonas , Gemella , and Leptotrichia are early bacterial markers for CRC, whereas, β-proteobacteria is a late-stage CRC marker. 57 − 59 Proteins such as human neutrophil peptides, S100 proteins, hemoglobin, haptoglobin, AAT, lactoferrin, CEA, exopeptidases (dipeptidyl peptidases I and IV), cadherin-17, selenium binding protein 1, tumor pyruvate kinase type M2, and MMP-9 are biomarkers of the stool. 60 The list of proteomic, genomic, and microbial biomarkers is shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Carbon-Based Nanomaterials as Drug Delivery Agents for Colorectal Cancer: Clinical Preface to Colorectal Cancer Citing Their Markers and Existing Theranostic Approaches

Wang

Ding

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the universally established cancers with a higher incidence rate. Novel progression toward cancer prevention and cancer care among countries in transition should be considered seriously for controlling CRC. Hence, several cutting edge technologies are ongoing for high performance cancer therapeutics over the past few decades. Several drug-delivery systems of the nanoregime are relatively new in this arena compared to the previous treatment modes such as chemoor radiotherapy to mitigate cancer. Based on this background, the epidemiology, pathophysiology, clinical presentation, treatment possibilities, and theragnostic markers for CRC were revealed. Since the use of carbon nanotubes (CNTs) for the management of CRC has been less studied, the present review analyzes the preclinical studies on the application of carbon nanotubes for drug delivery and CRC therapy owing to their inherent properties. It also investigates the toxicity of CNTs on normal cells for safety testing and the clinical use of carbon nanoparticles (CNPs) for tumor localization. To conclude, this review recommends the clinical application of carbon-based nanomaterials further for the management of CRC in diagnosis and as carriers or therapeutic adjuvants.

show abstract

“…Other interactions can arise from passive exposure such as through cosmetic products or food. Although NPs will likely first interact with epithelial and mucosal barriers, in some cases they are able to cross these barriers or potentially cause adverse effects, for example by interacting with the natural gut microbiome [14].…”

Section: General Introduction: the Need For Studying Nanoparticle-immune System Interactionsmentioning

confidence: 99%

Cross-Species Comparisons of Nanoparticle Interactions with Innate Immune Systems: A Methodological Review

et al. 2021

View full text Add to dashboard Cite

Many components of the innate immune system are evolutionarily conserved and shared across many living organisms, from plants and invertebrates to humans. Therefore, these shared features can allow the comparative study of potentially dangerous substances, such as engineered nanoparticles (NPs). However, differences of methodology and procedure between diverse species and models make comparison of innate immune responses to NPs between organisms difficult in many cases. To this aim, this review provides an overview of suitable methods and assays that can be used to measure NP immune interactions across species in a multidisciplinary approach. The first part of this review describes the main innate immune defense characteristics of the selected models that can be associated to NPs exposure. In the second part, the different modes of exposure to NPs across models (considering isolated cells or whole organisms) and the main endpoints measured are discussed. In this synergistic perspective, we provide an overview of the current state of important cross-disciplinary immunological models to study NP-immune interactions and identify future research needs. As such, this paper could be used as a methodological reference point for future nano-immunosafety studies.

show abstract

Influence of diet and dietary nanoparticles on gut dysbiosis

Cited by 13 publications

References 58 publications

Endogenous Fluorescence Carbon Dots Derived from Food Items

Endogenous Fluorescence Carbon Dots Derived from Food Items

Carbon-Based Nanomaterials as Drug Delivery Agents for Colorectal Cancer: Clinical Preface to Colorectal Cancer Citing Their Markers and Existing Theranostic Approaches

Cross-Species Comparisons of Nanoparticle Interactions with Innate Immune Systems: A Methodological Review

Contact Info

Product

Resources

About