Influence of diet on the risk of developing endometriosis

Abstract

Endometriosis is a hormone-dependent chronic inflammatory disease characterized by the presence of endometrium beyond the uterine cavity. The disease affects 5-15% of women of child-bearing age, 30-50% of whom suffer from infertility. Understanding the role of dietary factors in the development of endometriosis is critical to development of effective dietary instructions for prevention. Existing studies concerning nutrition and endometriosis suggest that diet is a potentially modifiable risk factor for endometriosis. Fruits and vegetables, fish oils, dairy products rich in calcium and vitamin D, and Omega-3 fatty acids are likely connected with a lower risk of developing endometriosis. Risk factors that increase the risk of endometriosis include consumption of products rich in trans-unsaturated fatty acids, consumption of fats generally, and consumption of beef and other kinds of red meat and alcohol. Currently, there are no clear correlations between particular food products and the risk of endometriosis. Further research is needed in order to fully understand the influence of consumed food products on the risk of development of this disease.

The assessment of GWAS — identified polymorphisms associated with infertility risk in Polish women with endometriosis

“…The presence of endometrial tissue and cells in the peritoneal cavity has been explained by the standard theory of retrograde menstruation along the fallopian tubes [4]. Although retrograde menstruation is observed in 90% of women, merely 10-20% of women suffer from endometriosis, which suggests the involvement of different genetic and environmental components in etiopathogenesis [5,6]. Recently, the genetic and epigenetic background of endometriosis has been demonstrated [5].…”

Vitamin D and endometriosis: looking for new opportunities

“…Научные исследования проблемы лечения эндометриоза сталкиваются с трудностями поиска доступной модели заболевания, так как эндометриоз встречается только у приматов, причем у животных приматов -с низкой частотой и медленным прогрессированием заболевания [48]. Была разработана модель эндометриоза на мышах путем инъекции фрагментов эндометриоидной ткани взрослым самкам мышей [47].…”

“…Исследования, касающиеся влияния образа питания на возникновение эндометриоза, показывают, что диета является потенциально модифицируемым фактором риска развития эндометриоза. Употребление фруктов и овощей, а также рыбьего жира, молочных продуктов, богатых кальцием и витамином D, и жирных кислот омега-3 связано с меньшим риском развития эндометриоза [48].…”

HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis

“…Depending on the severity of endometriosis, it can be subdivided into peritoneal, ovarian and deep lesions, which spread in the vagina, bowels, bladder or ureter [4,5]. Endometriosis is a complex disorder resulting from interactions between genetic and environmental factors [6,7]. The development of endometriosis is related to the abnormal expression of genes encoding proteins involved in vascular and tissue remodelling, enzymes involved in www.…”