“…The strong antioxidant effect of methanolic extract appears to be associated with its high total phenolic content. Several previous studies ( Abd El-Hack et al, 2019 , Abd El-Hack et al, 2020a , Abd El-Moneim and Sabic, 2019 , Abd El-Moneim et al, 2019 , Abdel-Moneim et al, 2020c , Elbaz et al, 2021 ) proposed synergetic effect between the bioactive compounds, particularly polyphenols, flavonoids, pigments, polysaccharides, chlorophyll, and polyunsaturated fatty acids. Despite the strong antioxidant activity of polyphenols and flavonoids, the total carotenoid content showed a higher positive correlation with the antioxidant activity than the total phenolic and flavonoid content in some extracts of Spirulina products ( Park et al, 2018 ).…”