Influence of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected enzymatic and histological parameters of liver in gilts

Tiemann, Ute; Brüssow, Klaus‐Peter; Küchenmeister, U.; Jonas, Ludwig; Kohlschein, Peter; Pöhland, Ralf; Dänicke, Sven

doi:10.1016/j.fct.2006.01.021

Cited by 58 publications

(40 citation statements)

References 22 publications

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“…Our results agree with the previously published reports suggesting the hepatotoxic potential of DON (Bradlaw et al, 1985;Rizzo et al, 1994;Drochner et al, 2006;Tiemann et al, 2006;Collins et al, 2006). Bradlaw et al (1985) demonstrated the cytotoxic effect of DON on primary rat hepatocytes in culture.…”

Section: Resultssupporting

confidence: 95%

“…A review of the literature suggested that the conflicting reports of the hepatotoxic potential of DON might be related to the animal model used (Forsell et al, 1986;Rizzo et al, 1994;Danicke et al, 2006;Drochner et al, 2006;Frankic et al, 2006;Gouze et al, 2005;Tiemann et al, 2006) or species-dependent. The objective of the study presented here was to test this hypothesis using liver cells from different species including rat (normal rat liver Clone9 and rat hepatocellular carcinoma MH1C1 cells), mouse (normal mouse embryonic liver BNL CL2 cells) and human (normal human embryonic liver WRL68 and human hepatocellular carcinoma HepG2 cells).…”

Section: Introductionmentioning

confidence: 95%

“…A systematic assessment of its hepatotoxic potential has not been undertaken. A few animal studies evaluating the adverse systemic effects of DON, including the liver, have reported very conflicting results on its hepatotoxic potential depending on the animal model used (Forsell et al, 1986;Rizzo et al, 1994;Danicke et al, 2006;Drochner et al, 2006;Frankic et al, 2006;Gouze et al, 2006;Tiemann et al, 2006). These conflicting reports led us to undertake a systematic study on the hepatotoxic potential of DON.…”

Section: Introductionmentioning

confidence: 96%

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Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture

Sahu

O’Donnell

Wiesenfeld

2010

J of Applied Toxicology

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The present study was undertaken to assess, in vitro, the hepatotoxic potential of the food-borne mycotoxin, deoxynivalenol (DON), using rat (Clone9 and MH1C1), mouse (NBL CL2) and human (WRL68 and HepG2) liver cells in culture. The cells were treated with DON for 24 h at 37 degrees C in 5% CO(2) at concentrations of 0-25 microg ml(-1). Following the treatment period, the cells were assayed for biochemical markers of hepatotoxicity that included three independent cytotoxicity assays, oxidative stress and mitochondrial dysfunction. Concentration-dependent cytotoxicity of DON was observed in each of the five different liver cells derived from three different species (rat, mouse and human) over the entire concentration range studied, beginning at 0.1 microg ml(-1). At these concentrations DON did not induce a biologically significant increase in oxidative stress in these liver cells, and showed a significant decrease in the mitochondrial function only in the rat liver MH1C1 cells compared with the control. The results of this in vitro study suggest that DON is a potential hepatotoxin for the rat, mouse and human liver cells in the concentration range tested in this study. The liver cells used in this study showed distinct endpoint-sensitivity to DON related to the species.

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Section: Resultssupporting

confidence: 95%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture

Sahu

O’Donnell

Wiesenfeld

2010

J of Applied Toxicology

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“…They are released into the blood stream proportionally to the number of damaged cells, and they are used as markers of inflammation (Tiemann et al 2006). In group E, AlAT values were characterized by a decreasing trend, but they were significantly higher than in group C throughout the experiment (Fig.…”

Section: Discussionmentioning

confidence: 99%

The effects of dietary deoxynivalenol (DON) on selected blood biochemical and hematological parameters in pre-pubertal gilts

Zielonka

Gajęcka

Tarasiuk

et al. 2015

Polish Journal of Veterinary Sciences

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The aim of this study was to determine whether exposure to low doses of DON leads to changes in serum hematological and biochemical profiles. In the experiment, pre-pubertal gilts (with body weight of up to 25 kg) were administered DON per os at a daily dose of 12 μg/kg BW (group E, n=18) or a placebo (group C, n=21) over a period of 42 days. Blood for analysis was sampled seven times at weekly intervals. Minor, but statistically significant changes were observed in selected indicators, particularly in weeks 2 and 3 in values of biochemical parameters such AlAT, AspAT, P in and Fe, and in values of hematological parameters such as RBC, MCV, MCHC, PLT, MPV, WBC, neutrophil, eosinophil, lymphocyte and monocyte counts. In group E, a decreasing trend of the values was observed in most cases, except for RBC, PLT, eosinophil, lymphocyte and monocyte counts. Similar results were obtained in the last two weeks of the experiment. Initially, exposure to DON has a stimulating effect, which is eliminated when adaptive mechanisms are triggered. The results of the study indicate that the intensity of biotransformation processes varies subjected to the body's energy resources.

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“…44 Several stages of hepatic lipid metabolism can be impaired by numerous toxins, causing hepatic lipid accumulation. 44 Among the toxins most relevant for cattle in Germany are aflatoxins, 5 DON, 48 and PAs. 20 DON and PA concentrations above the RR were detected in the liver of 1 affected calf.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Lipodystrophy in Galloway Calves

et al. 2017

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Hepatic lipodystrophy in Galloway calves is a fatal liver disease affecting a small proportion of the Galloway breed described in different parts of Europe and North America during the past decades. The clinical findings include a diversity of neurological signs. Clinical pathology findings frequently indicate hepatobiliary disease. Postmortem examination reveals an enlarged, pale yellow, and firm liver. Histologic lesions include hepatic fibrosis, hepatic lipidosis, and bile duct hyperplasia. To date, the etiopathogenesis remains obscure. Infectious causes, intoxications, and a hereditary origin have been considered. We describe hepatic lipodystrophy in Galloway calves from an extensively farmed cow-calf operation in southern Germany. Main clinical findings in 6 calves were consistent with hepatic encephalopathy. Clinical pathology findings in 5 of 6 tested animals revealed increased concentration of total bilirubin (maximum value [MV], 54 mmol/l; reference range [RR], <8

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Influence of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected enzymatic and histological parameters of liver in gilts

Cited by 58 publications

References 22 publications

Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture

Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture

The effects of dietary deoxynivalenol (DON) on selected blood biochemical and hematological parameters in pre-pubertal gilts

Hepatic Lipodystrophy in Galloway Calves

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