2015
DOI: 10.4149/neo_2015_086
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Influence of different chemical agents (H2O2, t-BHP and MMS) on the activity of antioxidant enzymes in human HepG2 and hamster V79 cells; relationship to cytotoxicity and genotoxicity

Abstract: We investigated activities of antioxidant enzymes (AEs), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in human HepG2 and hamster V79 cells treated with a scale of concentrations of hydrogen peroxide (H2O2), tert-butyl hydroperoxide (t-BHP) and methyl methanesulfonate (MMS). Cytotoxicity and genotoxicity of these substances were evaluated simultaneously. We have found out that H2O2, t-BHP and MMS predictably induce significant concentration-dependent increase of DNA lesions in bot… Show more

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Cited by 3 publications
(1 citation statement)
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“…SOD can catalyse superoxygen anion free radical disambiguation to generate oxygen and hydrogen peroxide and plays a crucial role in the balance of body oxidation and antioxidant oxidation, and Cu/Zn-SOD and Mn-SOD are the two important classes present in mammals [ 29 ]. CAT is an enzymatic scavenger that drives the breakdown of H 2 O 2 into molecular oxygen and water, and its enzymatic activity provides an antioxidant defence for the body [ 30 ]. Both SOD and CAT act as antioxidant enzymes that can prevent ROS from causing damage to the body, and they are also effective active substances that can reduce the oxidative stress that causes thrombosis [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…SOD can catalyse superoxygen anion free radical disambiguation to generate oxygen and hydrogen peroxide and plays a crucial role in the balance of body oxidation and antioxidant oxidation, and Cu/Zn-SOD and Mn-SOD are the two important classes present in mammals [ 29 ]. CAT is an enzymatic scavenger that drives the breakdown of H 2 O 2 into molecular oxygen and water, and its enzymatic activity provides an antioxidant defence for the body [ 30 ]. Both SOD and CAT act as antioxidant enzymes that can prevent ROS from causing damage to the body, and they are also effective active substances that can reduce the oxidative stress that causes thrombosis [ 31 ].…”
Section: Discussionmentioning
confidence: 99%