Influence of different estrogens on neuroplasticity and cognition in the hippocampus

Barha, Cindy K.; Galea, Liisa A.M.

doi:10.1016/j.bbagen.2010.01.006

Cited by 158 publications

(130 citation statements)

References 209 publications

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“…In the present study, we evaluated the estrous cycle and collected liver samples during a defined time window to better capture all of the stages of the estrous cycle. Estradiol levels peak during the early portion of the proestrus stage, which often occurs in the morning, and then return to baseline within 24 hours (17). Luteinizing hormone, follicular stimulating hormone and progesterone levels peak later during proestrus and decrease to baseline at end of the proestrus day (17,18).…”

Section: Discussionmentioning

confidence: 99%

“…Estradiol levels peak during the early portion of the proestrus stage, which often occurs in the morning, and then return to baseline within 24 hours (17). Luteinizing hormone, follicular stimulating hormone and progesterone levels peak later during proestrus and decrease to baseline at end of the proestrus day (17,18). During estrus, estradiol levels increase to a lesser extent than during proestrus, and return to baseline during estrus (17).…”

Section: Discussionmentioning

confidence: 99%

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Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking

Cao

Felmlee

2017

J Pharm Pharm Sci

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-Purpose: Monocarboxylate transporters (MCTs) are involved in the transport of monocarboxylates such as ketone bodies, lactate, and pharmaceutical agents. CD147 functions as an ancillary protein for MCT1 and MCT4 for plasma membrane trafficking. Sex differences in MCT1 and MCT4 have been observed in muscle and reproductive tissues; however, there is a paucity of information on MCT sex differences in tissues involved in drug disposition. The objective of the present study was to quantify hepatic MCT1, MCT4 and CD147 mRNA, total cellular and membrane protein expression in males, over the estrous cycle in females and in ovariectomized (OVX) females. Method: Liver samples were collected from females at the four estrous cycle stages (proestrus, estrus, metestrus, diestrus), OVX females and male Sprague-Dawley rats (N = 3 -5). Estrus cycle stage of females was determined by vaginal lavage. mRNA and protein (total and membrane) expression of MCT1, MCT4 and CD147 was evaluated by qPCR and western blot analysis. Results: MCT1 mRNA and membrane protein expression varied with estrous cycle stage, with OVX females having higher expression than males, indicating that female sex hormones may play a role in MCT1 regulation. MCT4 membrane expression varied with estrous cycle stage with expression significantly lower than males. MCT4 membrane expression in OVX females was also lower than males, suggesting that androgens play a role in membrane expression of MCT4. Males had higher membrane CD147 expression, whereas there was no difference in whole cell protein and mRNA levels suggesting that androgens are involved in regulating CD147 membrane localization. Conclusions: This study demonstrates hepatic expression and membrane localization of MCT1, MCT4 and CD147 are regulated by sex hormones. Sex differences in hepatic MCT expression may lead to altered drug disposition, so it is critical to elucidate the underlying mechanisms in the sex hormone-dependent regulation of MCT expression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking

Cao

Felmlee

2017

J Pharm Pharm Sci

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“…Nevertheless, it is important that investigators consider the possible effects of sex steroid hormones on neural function and behavior in their experimental designs and data interpretation. However, when thinking about sex differences in brain function or behavior, it is important to note whether differences are due to the activational effects of circulating hormones in adulthood or from organizational effects of hormones in early development, as it has been argued that only the latter can be construed as a true sex difference (McCarthy and Konkle 2005).Numerous recent reviews have discussed the effects of E 2 on learning and memory in females (Korol 2002;Foster 2005;Daniel 2006Daniel , 2013Sherwin and Henry 2008;Barha and Galea 2010;Bimonte-Nelson et al 2010;Gibbs 2010;Kim and Casadesus 2010;Choleris et al 2012;Foster 2012;Frick 2012;Acosta et al 2013;Chisolm and Juraska 2013;Ervin et al 2013;Galea et al 2013;Hogervorst 2013;Luine and Frankfurt 2013;Maki 2013;Bean et al 2014;Luine 2014;Frankfurt and Luine 2015;Tuscher et al 2015). As such, this review will not attempt to provide a comprehensive discussion of all effects of E 2 on learning and memory.…”

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confidence: 99%

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

et al. 2015

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Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen 17b-estradiol (E 2 ), affect hippocampal morphology, plasticity, and memory in male and female rodents. Yet relatively few investigators who work with male subjects consider the effects of these hormones on learning and memory. This review describes the effects of E 2 on hippocampal spinogenesis, neurogenesis, physiology, and memory, with particular attention paid to the effects of E 2 in male rodents. The estrogen receptors, cell-signaling pathways, and epigenetic processes necessary for E 2 to enhance memory in female rodents are also discussed in detail. Finally, practical considerations for working with female rodents are described for those investigators thinking of adding females to their experimental designs.Hormones have long been known to play key roles in regulating learning and memory. Many hormones, including epinephrine, glucocorticoids, and insulin influence learning and memory via inverted U-shaped dose-response relationships in which memory is enhanced by moderate, but not low or high, hormone levels (Roozendaal 2000;Korol and Gold 2007;McNay and Recknagel 2011). Research from the past two decades has demonstrated that sex steroid hormones, particularly the potent estrogen 17b-estradiol (E 2 ), also regulate learning and memory in male and female rodents via an inverted U-shaped dose-response function that is influenced by estrogen receptor expression (Packard and Teather 1997a;Packard 1998;Foster 2012). Yet E 2 has not gained widespread acceptance as a hormonal modulator of memory in both females and males, perhaps because the majority of this research has been conducted in female rodents. Moreover, the common view of E 2 as a "female" hormone may contribute to the misperception that E 2 is not relevant for cognitive function in males. However, considerable evidence supports a vital role for E 2 in mediating neural function and behavior in male rodents. Therefore, it is important for investigators working with males to understand the ways in which E 2 and other sex steroid hormones (e.g., androgens, progestins, and other estrogens) may influence their brain regions and behaviors of interest.Another reason for investigators to be cognizant of sex steroid hormone-induced regulation of learning and memory is that males and females may respond differently to various treatments and environmental factors. A classic example is that of acute stress, which enhances classical conditioning and increases apical CA1 dendritic spine density in male rats, but impairs classical conditioning and decreases CA1 spine density in female rats (Wood and Shors 1998;Shors et al. 2001). Therefore, investigators hoping to comply with National Institutes of Health policies that encourage the inclusion of females in biomedical research must be aware that adding females to a study is not as simple as adding another group. In some ways, females are fundamentally different from males, the most obvious of which is the presence of reproductive...

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“…But in Proestrus and estrus, estrogen levels are high (Figure2). Proestrus period between analyzes of corpus luteum in the previous cycle and the new cycle and during the Proestrus stage follicular growth graph is completed, the vaginal smear often composed of nucleated epithelial cells [15,16]. The results showed that the number of cells with the marker GFAP positive reaction to the change of estrous cycle and fluctuating hormones especially estrogen change.…”

Section: The Results Of Histological Observationsmentioning

confidence: 70%

Neurogenesis in the Dentate Gyrus of the Hippocampus Associated with Sex Hormone Levels in Female Mice

Pop¹,

Mt²

2018

Journal of Cell Biology and Histology

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Background: Usual fluctuations of sex hormones during the estrous cycle in female mice affect the hippocampal neurogenesis. The hippocampus also comprises many steroid receptors suggesting the modulatory effects of gonadal hormones on the hippocampal plasticity. Sex differences at the level of structure and function of the hippocampus are mostly due to the fluctuations of steroid hormones during the estrous cycle. The purpose of this study was to investigate relationship with serum sex hormone levels and the expression of glial fibrillary acidic protein (GFAP) at different phases of the estrous cycle.

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Influence of different estrogens on neuroplasticity and cognition in the hippocampus

Cited by 158 publications

References 209 publications

Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking

Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

Neurogenesis in the Dentate Gyrus of the Hippocampus Associated with Sex Hormone Levels in Female Mice

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